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Proteome analysis o...
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Carlén, Lina M
(författare)
Proteome analysis of skin distinguishes acute guttate from chronic plaque psoriasis.
- Artikel/kapitelEngelska2005
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-110768
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-110768URI
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https://doi.org/10.1111/j.0022-202X.2004.23501.xDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1953249URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Psoriasis is a disease with considerable heterogeneity in clinical presentation. This is the first study using two-dimensional gel electrophoresis to compare global protein expression patterns in lesional and non-lesional skin from subjects with acute guttate psoriasis associated with streptococcal throat infection and chronic plaque psoriasis. Samples from experimentally induced contact eczema and normal skin from healthy controls were also included. Proteins with statistically significant differences in expression were used in hierarchical cluster analyses resulting in separation of the different samples into groups. Chronic plaque and guttate psoriasis samples were distinctly separated, indicating that they represent discrete phenotypes at the protein expression level. Interestingly, there was a trend in which guttate psoriasis lesions clustered closer to eczema than to chronic plaque psoriasis lesions, indicating that the duration of the inflammatory reaction may affect clustering. Several of the differentially expressed proteins were identified by mass spectrometry.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sánchez, FabioKarolinska Institutet
(författare)
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Bergman, Ann-CharlotteKarolinska Institutet
(författare)
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Becker, Susanne
(författare)
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Hirschberg, Daniel
(författare)
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Franzén, BoKarolinska Institutet
(författare)
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Coffey, Jonathan
(författare)
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Jörnvall, HansKarolinska Institutet
(författare)
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Auer, GertKarolinska Institutet
(författare)
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Alaiya, Ayodele A
(författare)
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Ståhle, MonaKarolinska Institutet
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Investigative Dermatology124:10022-202X1523-1747
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Till lärosätets databas
- Av författaren/redakt...
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Carlén, Lina M
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Sánchez, Fabio
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Bergman, Ann-Cha ...
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Becker, Susanne
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Hirschberg, Dani ...
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Franzén, Bo
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visa fler...
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Coffey, Jonathan
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Jörnvall, Hans
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Auer, Gert
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Alaiya, Ayodele ...
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Ståhle, Mona
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visa färre...
- Artiklar i publikationen
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Journal of Inves ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet