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Effect of granulocy...
Effect of granulocyte colony-stimulating factor (G-CSF)-supported chemotherapy on MR imaging of normal red bone marrow in breast cancer patients with focal bone metastases
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- Ciray, I. (author)
- Uppsala universitet,Enheten för radiologi
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Lindman, H. (author)
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- Astrom, G. K. (author)
- Uppsala universitet,Enheten för radiologi
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Wanders, A. (author)
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Bergh, J. (author)
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- Ahlstrom, H. K. (author)
- Uppsala universitet,Enheten för radiologi
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(creator_code:org_t)
- 2003
- 2003
- English.
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In: Acta Radiol. - 0284-1851 .- 1600-0455. ; 44:5, s. 472-84
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Abstract
Subject headings
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- PURPOSE: To investigate the effect of granulocyte colony-stimulating factor (G-CSF)-supported chemotherapy on normal red bone marrow MR imaging in breast cancer patients with focal bone metastases. MATERIAL AND METHODS: Fifteen breast cancer patients who were examined before and after chemotherapy with T1-weighted-SE and long echo-time inversion-recovery turbo-spin-echo (long TE IR-TSE) sequences in the thoracolumbar spine and pelvis were retrospectively studied. Nine of them received G-CSF therapy after the administration of each chemotherapy course. Of these 9 patients, the MR follow-ups were performed during G-CSF in 4 patients and after G-CSF therapy in 5 patients. Six patients did not receive G-CSF. Signal intensity (SI) changes in normal bone marrow were evaluated visually in all patients and quantitatively in 13 patients. RESULTS: In all 4 patients investigated during G-CSF therapy a diffuse, homogeneous SI increase on long TE IR-TSE was observed visually and quantitatively in initially normal bone marrow. This change obscured some focal lesions in 2 patients. No such SI change was visible after G-CSF therapy (p = 0.008) or in patients not receiving G-CSF. On T1-weighted images an SI decrease was found both during and after G-CSF therapy, but an increase occurred in patients not receiving G-CSF. CONCLUSION: G-CSF-supported chemotherapy can induce diffuse SI changes in normal red bone marrow on MR imaging. On long TE IR-TSE, the changes are visible during G-CSF treatment and can lead to misinterpretations in the response evaluation of bone metastases to therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- Adult
- Aged
- Bone Marrow/*pathology
- Bone Neoplasms/*drug therapy/*secondary
- Breast Neoplasms/*pathology
- Drug Therapy
- Combination
- Granulocyte Colony-Stimulating Factor/*therapeutic use
- Humans
- *Magnetic Resonance Imaging
- Middle Aged
- Retrospective Studies
Publication and Content Type
- ref (subject category)
- art (subject category)
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