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Effect of LS-2616 o...
Effect of LS-2616 on the graft protection achieved by cyclosporin A, prednisolone, and 15-deoxyspergualin in heart-transplanted rats
- Article/chapterEnglish1992
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LIBRIS-ID:oai:DiVA.org:umu-110941
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-110941URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318441URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Wanders, A Gannedahl, G Gerdin, B Tufveson, G eng Germany 1992/01/01 00:00 Transpl Int. 1992;5 Suppl 1:S462-3.
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The immunostimulator LS-2616 abolishes the effect of cyclosporin A in a rat cardiac transplantation model. The present paper compares the characteristics of rejection obtained under different immunosuppressive regimens with and without additional LS-2616 application in the same model. Cyclosporin A (CyA, 10 mg/kg daily), prednisolone (15 mg/kg daily), or 15-deoxyspergualin (2, 5, or 10 mg/kg daily), all given from the day of transplantation until day 9, protected the grafts during the treatment period. The addition of LS-2616 (160 mg/kg, day -1 until stop) resulted in a total abrogation of the immunosuppressive effect of CyA and prednisolone. However, LS-2616 could only partially or not at all reverse the effect of 15-deoxyspergualine. These results show a certain drug selectivity of LS-2616 in promoting rejection of immunosuppressed allografts. Further studies with LS-2616 may be of benefit in evaluating the mode of action of different immunosuppressive compounds and, thus, contribute to finding more effective antirejection therapies.
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Gannedahl, G.
(author)
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Gerdin, Bengt,1947-
(author)
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Tufveson, G.
(author)
Related titles
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In:Transpl Int5 Suppl 1, s. S462-3
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In:Transplant International5 Suppl 1, s. S462-30934-08741432-2277
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