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  • Duarte-Salles, Talita (author)

Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-07-06
  • Wiley-Blackwell,2015
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-111284
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-111284URI
  • https://doi.org/10.1002/ijc.29643DOI
  • https://lup.lub.lu.se/record/7485327URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:132193830URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Fedirko, Veronika (author)
  • Stepien, Magdalena (author)
  • Aleksandrova, Krasimira (author)
  • Bamia, Christina (author)
  • Lagiou, Pagona (author)
  • Laursen, Anne Sofie Dam (author)
  • Hansen, Louise (author)
  • Overvad, Kim (author)
  • Tjønneland, Anne (author)
  • Boutron-Ruault, Marie-Christine (author)
  • Fagherazzi, Guy (author)
  • His, Mathilde (author)
  • Boeing, Heiner (author)
  • Katzke, Verena (author)
  • Kühn, Tilman (author)
  • Trichopoulou, Antonia (author)
  • Valanou, Elissavet (author)
  • Kritikou, Maria (author)
  • Masala, Giovanna (author)
  • Panico, Salvatore (author)
  • Sieri, Sabina (author)
  • Ricceri, Fulvio (author)
  • Tumino, Rosario (author)
  • Bueno-de-Mesquita, H B As (author)
  • Peeters, Petra H (author)
  • Hjartåker, Anette (author)
  • Skeie, Guri (author)
  • Weiderpass, ElisabeteKarolinska Institutet (author)
  • Ardanaz, Eva (author)
  • Bonet, Catalina (author)
  • Chirlaque, Maria-Dolores (author)
  • Dorronsoro, Miren (author)
  • Quirós, J Ramón (author)
  • Johansson, IngegerdUmeå universitet,Institutionen för odontologi,Näringsforskning(Swepub:umu)injo0003 (author)
  • Ohlsson, BodilLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)kir-boh (author)
  • Sjöberg, KlasLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups(Swepub:lu)medf-ksj (author)
  • Wennberg, MariaUmeå universitet,Näringsforskning(Swepub:umu)mawe0024 (author)
  • Khaw, Kay-Tee (author)
  • Travis, Ruth C (author)
  • Wareham, Nick (author)
  • Ferrari, Pietro (author)
  • Freisling, Heinz (author)
  • Romieu, Isabelle (author)
  • Cross, Amanda J (author)
  • Gunter, Marc (author)
  • Lu, YunxiaKarolinska Institutet (author)
  • Jenab, Mazda (author)
  • Karolinska InstitutetInstitutionen för odontologi (creator_code:org_t)

Related titles

  • In:International Journal of Cancer: Wiley-Blackwell137:11, s. 2715-27280020-71361097-0215

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