Search: (swepub) lar1:(umu) pers:(Riboli Elio) pers:(Chirlaque Maria Dolores) conttype:(refereed) pers:(Sánchez Maria José) >
Determinants of the...
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Kelly, Rachel S.
(author)
Determinants of the t(14;18) translocation and their role in t(14;18)-positive follicular lymphoma
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-09-30
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Springer Netherlands,2015
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-111988
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-111988URI
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https://doi.org/10.1007/s10552-015-0677-2DOI
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https://lup.lub.lu.se/record/8159827URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:132329468URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Purpose: The strong association between t(14;18) translocation and follicular lymphoma (FL) is well known. However, the determinants of this chromosomal aberration and their role in t(14;18) associated FL remain to be established.Methods: t(14;18) frequency within the B cell lymphoma 2 major breakpoint region was determined for 135 incident FL cases and 251 healthy controls as part of a nested case–control study within the European Prospective Investigation into Cancer cohort. Quantitative real-time PCR was performed in DNA extracted from blood samples taken at recruitment. The relationship between prevalence and frequency of the translocation with baseline anthropometric, lifestyle, and dietary factors in cases and controls was determined. Unconditional logistic regression was used to explore whether the risk of FL associated with these factors differed in t(14;18)+ as compared to t(14;18)− cases.Results: Among incident FL cases, educational level (χ 2 p = 0.021) and height (χ 2 p = 0.025) were positively associated with t(14;18) prevalence, and cases with high frequencies [t(14;18)HF] were significantly taller (t test p value = 0.006). These findings were not replicated in the control population, although there were a number of significant associations with dietary variables. Further analyses revealed that height was a significant risk factor for t(14;18)+ FL [OR 6.31 (95 % CI 2.11, 18.9) in the tallest versus the shortest quartile], but not t(14;18)− cases.Conclusions: These findings suggest a potential role for lifestyle factors in the prevalence and frequency of the t(14;18) translocation. The observation that the etiology of FL may differ by t(14;18) status, particularly with regard to height, supports the subdivision of FL by translocation status.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Roulland, Sandrine
(author)
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Morgado, Ester
(author)
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Sungalee, Stephanie
(author)
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Jouve, Nathalie
(author)
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Tumino, Rosario
(author)
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Krogh, Vittorio
(author)
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Panico, Salvatore
(author)
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Polidoro, Silvia
(author)
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Masala, Giovanna
(author)
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Sanchez, Maria-Jose
(author)
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Chirlaque, Maria-Dolores
(author)
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Sala, Nuria
(author)
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Barricarte Gurrea, Aurelio
(author)
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Dorronsoro, Miren
(author)
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Travis, Ruth C.
(author)
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Riboli, Elio
(author)
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Gunter, Marc
(author)
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Murphy, Neil
(author)
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Vermeulen, Roel
(author)
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Bueno-de-Mesquita, H. B.
(author)
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Peeters, Petra H.
(author)
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Trichopoulou, Antonia
(author)
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Trichopoulos, Dimitrios
(author)
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Lagiou, Pagona
(author)
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Nieters, Alexandra
(author)
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Canzian, Federico
(author)
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Kaaks, Rudolf
(author)
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Boeing, Heiner
(author)
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Weiderpass, ElisabeteKarolinska Institutet
(author)
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Stocks, TanjaLund University,Lunds universitet,Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap,Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)med-tss
(author)
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Melin, BeatriceUmeå universitet,Institutionen för strålningsvetenskaper,Head Regional Cancer Center North(Swepub:umu)bema0010
(author)
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Overvad, Kim
(author)
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Tjonneland, Anne
(author)
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Olsen, Anja
(author)
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Brennan, Paul
(author)
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Johansson, Mattias
(author)
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Nadel, Bertrand
(author)
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Vineis, Paolo
(author)
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Karolinska InstitutetInstitutionen för kirurgisk och perioperativ vetenskap
(creator_code:org_t)
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In:Cancer Causes and Control: Springer Netherlands26:12, s. 1845-18550957-52431573-7225
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Kelly, Rachel S.
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Roulland, Sandri ...
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Morgado, Ester
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Sungalee, Stepha ...
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Jouve, Nathalie
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Tumino, Rosario
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Krogh, Vittorio
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Panico, Salvator ...
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Polidoro, Silvia
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Sanchez, Maria-J ...
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Chirlaque, Maria ...
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Sala, Nuria
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Barricarte Gurre ...
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Dorronsoro, Mire ...
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Travis, Ruth C.
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Riboli, Elio
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Gunter, Marc
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Murphy, Neil
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Vermeulen, Roel
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Bueno-de-Mesquit ...
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Peeters, Petra H ...
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Trichopoulou, An ...
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Trichopoulos, Di ...
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Lagiou, Pagona
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Nieters, Alexand ...
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Canzian, Federic ...
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Kaaks, Rudolf
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Boeing, Heiner
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Weiderpass, Elis ...
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Stocks, Tanja
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Melin, Beatrice
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Overvad, Kim
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Tjonneland, Anne
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Olsen, Anja
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Brennan, Paul
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Johansson, Matti ...
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Nadel, Bertrand
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Vineis, Paolo
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