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The association of ...
The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury : data from the European Prospective Investigation into Cancer and Nutrition
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Aleksandrova, Krasimira (author)
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Bamia, Christina (author)
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Drogan, Dagmar (author)
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show more...
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Lagiou, Pagona (author)
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Trichopoulou, Antonia (author)
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Jenab, Mazda (author)
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Fedirko, Veronika (author)
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Romieu, Isabelle (author)
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Bueno-de-Mesquita, H. Bas (author)
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Pischon, Tobias (author)
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Tsilidis, Kostas (author)
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Overvad, Kim (author)
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Tjønneland, Anne (author)
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Bouton-Ruault, Marie-Christine (author)
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Dossus, Laure (author)
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Racine, Antoine (author)
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Kaaks, Rudolf (author)
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Kuehn, Tilman (author)
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Tsironis, Christos (author)
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Papatesta, Eleni-Maria (author)
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Saitakis, George (author)
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Palli, Domenico (author)
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Panico, Salvatore (author)
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Grioni, Sara (author)
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Tumino, Rosario (author)
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Vineis, Paolo (author)
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Peeters, Petra H. (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Lukic, Marko (author)
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Braaten, Tonje (author)
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Ramon Quiros, J. (author)
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Lujan-Barroso, Leila (author)
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Sanchez, Mara-Jose (author)
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Chilarque, Maria-Dolores (author)
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Ardanas, Eva (author)
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Dorronsoro, Miren (author)
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- Nilsson, Lena Maria, 1965- (author)
- Umeå universitet,Arktiskt centrum vid Umeå universitet (Arcum)
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- Sund, Malin, 1972- (author)
- Umeå universitet,Kirurgi,Näringsforskning
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- Wallström, Peter (author)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
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- Ohlsson, Bodil (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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Bradbury, Kathryn E. (author)
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Stepien, Magdalena (author)
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Duarte-Salles, Talita (author)
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Assi, Nada (author)
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Murphy, Neil (author)
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Gunter, Marc J. (author)
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Riboli, Elio (author)
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Boeing, Heiner (author)
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Trichopoulos, Dimitrios (author)
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(creator_code:org_t)
- American Society for Nutrition, 2015
- 2015
- English.
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In: American Journal of Clinical Nutrition. - : American Society for Nutrition. - 0002-9165 .- 1938-3207. ; 102:6, s. 1498-1508
- Related links:
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https://umu.diva-por... (primary) (Raw object)
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https://academic.oup...
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
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- Background: Higher coffee intake has been purportedly related to a lower risk of liver cancer. However, it remains unclear whether this association may be accounted for by specific biological mechanisms. Objective: We aimed to evaluate the potential mediating roles of inflammatory, metabolic, liver injury, and iron metabolism biomarkers on the association between coffee intake and the primary form of liver cancer-hepatocellular carcinoma (HCC). Design: We conducted a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition among 125 incident HCC cases matched to 250 controls using an incidence-density sampling procedure. The association of coffee intake with HCC risk was evaluated by using multivariable-adjusted conditional logistic regression that accounted for smoking, alcohol consumption, hepatitis infection, and other established liver cancer risk factors. The mediating effects of 21 biomarkers were evaluated on the basis of percentage changes and associated 95% CIs in the estimated regression coefficients of models with and without adjustment for biomarkers individually and in combination. Results: The multivariable-adjusted RR of having >= 4 cups (600mL) coffee/d compared with <2 cups (300 mL)/d was 0.25 (95% CI: 0.11, 0.62; P-trend = 0.006). A statistically significant attenuation of the association between coffee intake and HCC risk and thereby suspected mediation was confirmed for the inflammatory biomarker IL-6 and for the biomarkers of hepatocellular injury glutamate dehydrogenase, alanine aminotransferase, aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), and total bilirubin, which-in combination-attenuated the regression coefficients by 72% (95% CI: 7%, 239%). Of the investigated biomarkers, IL-6, AST, and GGT produced the highest change in the regression coefficients: 40%, 56%, and 60%, respectively. Conclusion: These data suggest that the inverse association of coffee intake with HCC risk was partly accounted for by biomarkers of inflammation and hepatocellular injury.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- biomarkers
- coffee
- European Prospective Investigation into Cancer and Nutrition
- liver cancer
- diation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Aleksandrova, Kr ...
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Bamia, Christina
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Drogan, Dagmar
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Lagiou, Pagona
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Trichopoulou, An ...
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Jenab, Mazda
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show more...
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Fedirko, Veronik ...
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Romieu, Isabelle
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Bueno-de-Mesquit ...
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Pischon, Tobias
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Tsilidis, Kostas
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Overvad, Kim
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Tjønneland, Anne
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Bouton-Ruault, M ...
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Dossus, Laure
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Racine, Antoine
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Kaaks, Rudolf
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Kuehn, Tilman
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Tsironis, Christ ...
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Papatesta, Eleni ...
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Saitakis, George
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Palli, Domenico
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Panico, Salvator ...
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Grioni, Sara
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Tumino, Rosario
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Vineis, Paolo
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Peeters, Petra H ...
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Weiderpass, Elis ...
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Lukic, Marko
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Braaten, Tonje
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Ramon Quiros, J.
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Lujan-Barroso, L ...
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Sanchez, Mara-Jo ...
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Chilarque, Maria ...
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Ardanas, Eva
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Dorronsoro, Mire ...
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Nilsson, Lena Ma ...
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Sund, Malin, 197 ...
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Wallström, Peter
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Ohlsson, Bodil
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Bradbury, Kathry ...
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Khaw, Kay-Tee
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Wareham, Nick
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Stepien, Magdale ...
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Duarte-Salles, T ...
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Assi, Nada
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Murphy, Neil
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Gunter, Marc J.
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Riboli, Elio
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Boeing, Heiner
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Trichopoulos, Di ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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American Journal ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet