Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study

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Ahmad, ShafqatLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups (author)

Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan : the PROMIS study

Article/chapterEnglish2015

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2015-12-18
BioMed Central,2015
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-114014
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-114014URI
https://doi.org/10.1186/s12881-015-0259-xDOI
https://lup.lub.lu.se/record/8504196URI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489432URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Background: Multiple genetic variants have been reliably associated with obesity-related traits in Europeans, but little is known about their associations and interactions with lifestyle factors in South Asians.Methods: In 16,157 Pakistani adults (8232 controls; 7925 diagnosed with myocardial infarction [MI]) enrolled in the PROMIS Study, we tested whether: a) BMI-associated loci, individually or in aggregate (as a genetic risk score - GRS), are associated with BMI; b) physical activity and smoking modify the association of these loci with BMI. Analyses were adjusted for age, age(2), sex, MI (yes/no), and population substructure.Results: Of 95 SNPs studied here, 73 showed directionally consistent effects on BMI as reported in Europeans. Each additional BMI-raising allele of the GRS was associated with 0.04 (SE = 0.01) kg/m(2) higher BMI (P = 4.5 x 10(-14)). We observed nominal evidence of interactions of CLIP1 rs11583200 (P-interaction = 0.014), CADM2 rs13078960 (P-interaction = 0.037) and GALNT10 rs7715256 (P-interaction = 0.048) with physical activity, and PTBP2 rs11165643 (P-interaction = 0.045), HIP1 rs1167827 (P-interaction = 0.015), C6orf106 rs205262 (P-interaction = 0.032) and GRID1 rs7899106 (P-interaction = 0.043) with smoking on BMI.Conclusions: Most BMI-associated loci have directionally consistent effects on BMI in Pakistanis and Europeans. There were suggestive interactions of established BMI-related SNPs with smoking or physical activity.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
Obesity
Physical activity
Smoking
Genetic susceptibility
Gene-lifestyle interactions

Added entries (persons, corporate bodies, meetings, titles ...)

Zhao, WeiPhiladelphia, PA, US (author)
Renström, FridaLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-frm (author)
Rasheed, AsifKarachi, Pakistan (author)
Samuel, MariaKarachi, Pakistan (author)
Zaidi, MozzamKarachi, Pakistan (author)
Shah, NabiKarachi, Pakistan; Abbottabad, Pakistan (author)
Mallick, Nadeem HayyatPunjab Institute of Cardiology, Lahore, Pakistan (author)
Zaman, Khan ShahKarachi, Pakistan (author)
Ishaq, MohammadKarachi, Pakistan (author)
Rasheed, Syed ZahedKarachi, Pakistan (author)
Memon, Fazal-ur-RhemanKarachi, Pakistan (author)
Hanif, BashirKarachi, Pakistan (author)
Lakhani, Muhammad ShakirKarachi, Pakistan (author)
Ahmed, FaisalKarachi, Pakistan (author)
Kazmi, Shahana UroojKarachi, Pakistan (author)
Frossard, PhilippeKarachi, Pakistan; Nazarbayev University, Astana, Kazakhstan (author)
Franks, Paul W.Lund University,Lunds universitet,Umeå universitet,Medicin,Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology(Swepub:lu)med-plf (author)
Saleheen, DanishPhiladelphia, PA, US; Karachi, Pakistan (author)
Genetisk och molekylär epidemiologiForskargrupper vid Lunds universitet (creator_code:org_t)

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