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The role of TREM2 R...
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Lill, Christina M.University of Lubeck, Germany; Max Planck Institute Molecular Genet, Germany
(author)
The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-04-29
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Wiley,2015
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-114026
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-114026URI
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https://doi.org/10.1016/j.jalz.2014.12.009DOI
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https://gup.ub.gu.se/publication/229728URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-123758URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|German Ministry for Education and Research (BMBF) [16SV5538, 01UW0808]; Cure Alzheimers Fund; Michael J. Fox Foundation; Innovation Fund of the Max Planck Society [M.FE.A.BILD0002]; Katharina-Hardt-Stiftung, Bad Homburg, Germany; AXA Research Fund; Fondation Universite Pierre et Marie Curie; Fondation pour la Recherche sur Alzheimer, Paris, France; MND Association UK; Research Council of Norway; South-Eastern Norway Regional Health Authority; NIEHS of the National Institutes of Health [R01ES013717]; European Union [QLK4-CT-1999-01133]; program "Investissements davenir" [ANR-10-IAIHU-06]
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A rare variant in TREM2 (p.R47H, rs75932628) was recently reported to increase the risk of Alzheimer's disease (AD) and, subsequently, other neurodegenerative diseases, i.e. frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease (PD). Here we comprehensively assessed TREM2 rs75932628 for association with these diseases in a total of 19,940 previously untyped subjects of European descent. These data were combined with those from 28 published data sets by meta-analysis. Furthermore, we tested whether rs75932628 shows association with amyloid beta (Ab42) and total-tau protein levels in the cerebrospinal fluid (CSF) of 828 individuals with AD or mild cognitive impairment. Our data show that rs75932628 is highly significantly associated with the risk of AD across 24,086 AD cases and 148,993 controls of European descent (odds ratio or OR = 2.71, P = 4.67 x 10(-25)). No consistent evidence for association was found between this marker and the risk of FTLD (OR = 2.24, P = .0113 across 2673 cases/9283 controls), PD (OR 5 1.36, P = .0767 across 8311 cases/79,938 controls) and ALS (OR 5 1.41, P = .198 across 5544 cases/7072 controls). Furthermore, carriers of the rs75932628 risk allele showed significantly increased levels of CSF-total-tau (P = .0110) but not Ab42 suggesting that TREM2's role in AD may involve tau dysfunction. (C) 2015 The Alzheimer's Association.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Rengmark, AinaOslo University Hospital, Norway
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Pihlstrom, LasseOslo University Hospital, Norway,Stavanger University Hospital, Norway
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Fogh, IsabellaKings Coll London, England
(author)
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Shatunov, AlekseyKings Coll London, England
(author)
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Sleiman, Patrick M.Childrens Hospital Philadelphia, PA 19104 USA; Childrens Hospital Philadelphia, PA 19104 USA; University of Penn, PA 19104 USA; University of Turin, Italy
(author)
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Wang, Li-SanUniversity of Penn, PA 19104 USA; University of Turin, Italy
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Liu, TianMax Planck Institute Human Dev, Germany
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Lassen, Christina F.Danish Cancer Soc, Denmark,Goethe University of Frankfurt, Germany
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Meissner, EstherMax Planck Institute Molecular Genet, Germany
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Alexopoulos, PanosTechnical University of Munich, Germany
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Calvo, AndreaUniversity of Turin, Italy
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Chio, AdrianoUniversity of Turin, Italy; Neurosci Institute Turin, Italy
(author)
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Dizdar (Dizdar Segrell), NilLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Klinisk kemi,Region Östergötland, Neurologiska kliniken i Linköping(Swepub:liu)nildi39
(author)
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Faltraco, FrankUniversity of Ulm, Germany
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Forsgren, LarsUmeå universitet,Klinisk neurovetenskap,Umeå University, Sweden(Swepub:umu)lafo0001
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Kirchheiner, JuliaUniversity of Ulm, Germany
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Kurz, AlexanderTechnical University of Munich, Germany
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Larsen, Jan P.
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Liebsch, MariaMax Planck Institute Molecular Genet, Germany
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Linder, JanUmeå universitet,Klinisk neurovetenskap,Umeå University, Sweden(Swepub:umu)jali0020
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Morrison, Karen E.University of Birmingham, England; University Hospital Birmingham, England
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Nissbrandt, Hans,1952Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,University of Gothenburg, Sweden(Swepub:gu)xnisha
(author)
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Otto, MarkusUniversity of Ulm, Germany
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Pahnke, JensUniversity of Oslo, Norway; Oslo University Hospital, Norway; University of Lubeck, Germany
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Partch, AmandaUniversity of Penn, PA 19104 USA
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Restagno, GabriellaAzienda Osped Citta Salute and Science, Italy
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Rujescu, DanUniversity of Halle Wittenberg, Germany
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Schnack, CathrinUniversity of Ulm, Germany
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Shaw, Christopher E.Kings Coll London, England
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Shaw, Pamela J.University of Sheffield, England
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Tumani, HayrettinUniversity of Ulm, Germany
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Tysnes, Ole-BjornHaukeland Hospital, Norway; University of Bergen, Norway
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Valladares, OttoUniversity of Penn, PA 19104 USA
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Silani, VincenzoIRCCS Ist Auxol Italiano, Italy; University of Milan, Italy
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van den Berg, Leonard H.University of Medical Centre Utrecht, Netherlands,Childrens Hospital Philadelphia, PA 19104 USA; Childrens Hospital Philadelphia, PA 19104 USA; University of Penn, PA 19104 USA,AXA Research Fund, France; University of Sorbonne, France
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van Rheenen, WouterUniversity of Medical Centre Utrecht, Netherlands
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Veldink, Jan H.University of Medical Centre Utrecht, Netherlands
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Lindenberger, UlmanMax Planck Institute Human Dev, Germany
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Steinhagen-Thiessen, ElisabethCharite, Germany
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Teipel, StefanGerman Centre Neurodegenerat Disease DZNE, Germany; University of Rostock, Germany
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Perneczky, RobertTechnical University of Munich, Germany; University of London Imperial Coll Science Technology and Med, England; West London Mental Health Trust, England
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Hakonarson, HakonDanish Cancer Soc, Denmark
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Hampel, Harald
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von Arnim, Christine A. F.
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Olsen, Jorgen H.
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Van Deerlin, Vivianna M.University of Penn, PA 19104 USA; University of Turin, Italy
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Al-Chalabi, AmmarKings Coll London, England
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Toft, MathiasOslo University Hospital, Norway
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Ritz, BeateICM, France
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Bertram, LarsMax Planck Institute Molecular Genet, Germany; University of Calif Los Angeles, CA USA
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University of Lubeck, Germany; Max Planck Institute Molecular Genet, GermanyOslo University Hospital, Norway
(creator_code:org_t)
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In:Alzheimer's & Dementia: Wiley11:12, s. 1407-14161552-52601552-5279
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Lill, Christina ...
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Rengmark, Aina
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Pihlstrom, Lasse
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Fogh, Isabella
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Shatunov, Alekse ...
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Sleiman, Patrick ...
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Wang, Li-San
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Liu, Tian
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Lassen, Christin ...
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Meissner, Esther
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Alexopoulos, Pan ...
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Calvo, Andrea
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Chio, Adriano
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Dizdar (Dizdar S ...
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Faltraco, Frank
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Forsgren, Lars
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Kirchheiner, Jul ...
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Kurz, Alexander
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Larsen, Jan P.
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Liebsch, Maria
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Linder, Jan
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Morrison, Karen ...
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Nissbrandt, Hans ...
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Otto, Markus
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Pahnke, Jens
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Partch, Amanda
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Restagno, Gabrie ...
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Rujescu, Dan
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Schnack, Cathrin
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Shaw, Christophe ...
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Shaw, Pamela J.
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Tumani, Hayretti ...
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Tysnes, Ole-Bjor ...
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Valladares, Otto
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Silani, Vincenzo
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van den Berg, Le ...
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van Rheenen, Wou ...
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Veldink, Jan H.
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Lindenberger, Ul ...
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Steinhagen-Thies ...
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Teipel, Stefan
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Perneczky, Rober ...
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Hakonarson, Hako ...
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Hampel, Harald
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von Arnim, Chris ...
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Olsen, Jorgen H.
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Van Deerlin, Viv ...
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Toft, Mathias
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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MEDICAL AND HEAL ...
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Alzheimer's & De ...
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Umeå University
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University of Gothenburg
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Linköping University