Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference

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Wen, Wanqing (author)

Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference

Article/chapterEnglish2016

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2016-01-20
Springer Science and Business Media LLC,2016
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-116073
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-116073URI
https://doi.org/10.1038/srep17958DOI
https://lup.lub.lu.se/record/8576896URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in Europeanancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3, CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
genetic loci
abdominal obesity

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Kato, Norihiro (author)
Hwang, Joo-Yeon (author)
Guo, Xingyi (author)
Tabara, Yasuharu (author)
Li, Huaixing (author)
Dorajoo, Rajkumar (author)
Yang, Xiaobo (author)
Tsai, Fuu-Jen (author)
Li, Shengxu (author)
Wu, Ying (author)
Wu, Tangchun (author)
Kim, Soriul (author)
Guo, Xiuqing (author)
Liang, Jun (author)
Shungin, DmitryLund University,Lunds universitet,Umeå universitet,Medicin,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-dsn (author)
Adair, Linda S. (author)
Akiyama, Koichi (author)
Allison, Matthew (author)
Cai, Qiuyin (author)
Chang, Li-Ching (author)
Chen, Chien-Hsiun (author)
Chen, Yuan-Tsong (author)
Cho, Yoon Shin (author)
Choi, Bo Youl (author)
Gao, Yutang (author)
Go, Min Jin (author)
Gu, Dongfeng (author)
Han, Bok-Ghee (author)
He, Meian (author)
Hixson, James E. (author)
Hu, Yanling (author)
Huang, Tao (author)
Isono, Masato (author)
Jung, Keum Ji (author)
Kang, Daehee (author)
Kim, Young Jin (author)
Kita, Yoshikuni (author)
Lee, Juyoung (author)
Lee, Nanette R. (author)
Lee, Jeannette (author)
Wang, Yiqin (author)
Liu, Jian-Jun (author)
Long, Jirong (author)
Moon, Sanghoon (author)
Nakamura, Yasuyuki (author)
Nakatochi, Masahiro (author)
Ohnaka, Keizo (author)
Rao, Dabeeru (author)
Shi, Jiajun (author)
Sull, Jae Woong (author)
Tan, Aihua (author)
Ueshima, Hirotsugu (author)
Wu, Chen (author)
Xiang, Yong-Bing (author)
Yamamoto, Ken (author)
Yao, Jie (author)
Ye, Xingwang (author)
Yokota, Mitsuhiro (author)
Zhang, Xiaomin (author)
Zheng, Yan (author)
Qi, Lu (author)
Rotter, Jerome I. (author)
Jee, Sun Ha (author)
Lin, Dongxin (author)
Mohlke, Karen L. (author)
He, Jiang (author)
Mo, Zengnan (author)
Wu, Jer-Yuarn (author)
Tai, E. Shyong (author)
Lin, Xu (author)
Miki, Tetsuro (author)
Kim, Bong-Jo (author)
Takeuchi, Fumihiko (author)
Zheng, Wei (author)
Shu, Xiao-Ou (author)
Umeå universitetMedicin (creator_code:org_t)

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By the author/editor: Wen, Wanqing; Kato, Norihiro; Hwang, Joo-Yeon; Guo, Xingyi; Tabara, Yasuharu; Li, Huaixing; show more...; Dorajoo, Rajkuma ...; Yang, Xiaobo; Tsai, Fuu-Jen; Li, Shengxu; Wu, Ying; Wu, Tangchun; Kim, Soriul; Guo, Xiuqing; Liang, Jun; Shungin, Dmitry; Adair, Linda S.; Akiyama, Koichi; Allison, Matthew; Cai, Qiuyin; Chang, Li-Ching; Chen, Chien-Hsiu ...; Chen, Yuan-Tsong; Cho, Yoon Shin; Choi, Bo Youl; Gao, Yutang; Go, Min Jin; Gu, Dongfeng; Han, Bok-Ghee; He, Meian; Hixson, James E.; Hu, Yanling; Huang, Tao; Isono, Masato; Jung, Keum Ji; Kang, Daehee; Kim, Young Jin; Kita, Yoshikuni; Lee, Juyoung; Lee, Nanette R.; Lee, Jeannette; Wang, Yiqin; Liu, Jian-Jun; Long, Jirong; Moon, Sanghoon; Nakamura, Yasuyu ...; Nakatochi, Masah ...; Ohnaka, Keizo; Rao, Dabeeru; Shi, Jiajun; Sull, Jae Woong; Tan, Aihua; Ueshima, Hirotsu ...; Wu, Chen; Xiang, Yong-Bing; Yamamoto, Ken; Yao, Jie; Ye, Xingwang; Yokota, Mitsuhir ...; Zhang, Xiaomin; Zheng, Yan; Qi, Lu; Rotter, Jerome I ...; Jee, Sun Ha; Lin, Dongxin; Mohlke, Karen L.; He, Jiang; Mo, Zengnan; Wu, Jer-Yuarn; Tai, E. Shyong; Lin, Xu; Miki, Tetsuro; Kim, Bong-Jo; Takeuchi, Fumihi ...; Zheng, Wei; Shu, Xiao-Ou; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

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