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Human Papillomaviru...
Human Papillomavirus 16 E6 Antibodies in Individuals without Diagnosed Cancer : A Pooled Analysis
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Lang Kuhs, Krystle A (author)
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Anantharaman, Devasena (author)
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Waterboer, Tim (author)
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- Johansson, Mattias (author)
- International Agency for Research on Cancer (IARC), Lyon, France
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Brennan, Paul (author)
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Michel, Angelika (author)
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Willhauck-Fleckenstein, Martina (author)
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Purdue, Mark P (author)
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Holcátová, Ivana (author)
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Ahrens, Wolfgang (author)
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Lagiou, Pagona (author)
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Polesel, Jerry (author)
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Simonato, Lorenzo (author)
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Merletti, Franco (author)
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Healy, Claire M (author)
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Kjaerheim, Kristina (author)
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Conway, David I (author)
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Macfarlane, Tatiana V (author)
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Thomson, Peter (author)
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Castellsagué, Xavier (author)
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Znaor, Ariana (author)
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Black, Amanda (author)
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Huang, Wen-Yi (author)
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Krogh, Vittorio (author)
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Trichopoulou, Antonia (author)
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Bueno-de-Mesquita, H B As (author)
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Clavel-Chapelon, Françoise (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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- Ekström, Johanna (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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Riboli, Elio (author)
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Tjønneland, Anne (author)
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Sánchez, María-José (author)
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Travis, Ruth C (author)
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Hildesheim, Allan (author)
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Pawlita, Michael (author)
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Kreimer, Aimée R (author)
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(creator_code:org_t)
- American Association for Cancer Research, 2015
- 2015
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 24:4, s. 683-689
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
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- BACKGROUND: The increasing incidence of oropharyngeal cancer in many developed countries has been attributed to human papillomavirus type 16 (HPV16) infections. Recently, HPV16 E6 serology has been identified as a promising early marker for oropharyngeal cancer. Therefore, characterization of HPV16 E6 seropositivity among individuals without cancer is warranted.METHODS: A total of 4,666 controls were pooled from several studies of cancer and HPV seropositivity, all tested within the same laboratory. HPV16 E6 seropositive controls were classified as having (i) moderate [mean fluorescent intensity (MFI) ≥ 484 and <1,000] or (ii) high seroreactivity (MFI ≥ 1,000). Associations of moderate and high HPV16 E6 seroreactivity with (i) demographic risk factors; and seropositivity for (ii) other HPV16 proteins (E1, E2, E4, E7, and L1), and (iii) E6 proteins from non-HPV16 types (HPV6, 11, 18, 31, 33, 45, and 52) were evaluated.RESULTS: Thirty-two (0.7%) HPV16 E6 seropositive controls were identified; 17 (0.4%) with moderate and 15 (0.3%) with high seroreactivity. High HPV16 E6 seroreactivity was associated with former smoking [odds ratio (OR), 5.5; 95% confidence interval (CI), 1.2-51.8], and seropositivity against HPV16 L1 (OR, 4.8; 95% CI, 1.3-15.4); E2 (OR, 7.7; 95% CI, 1.4-29.1); multiple HPV16 proteins (OR, 25.3; 95% CI, 2.6-119.6 for three HPV16 proteins beside E6) and HPV33 E6 (OR, 17.7; 95% CI, 1.9-81.8). No associations were observed with moderate HPV16 E6 seroreactivity.CONCLUSIONS: High HPV16 E6 seroreactivity is rare among individuals without diagnosed cancer and was not explained by demographic factors.IMPACT: Some HPV16 E6 seropositive individuals without diagnosed HPV-driven cancer, especially those with seropositivity against other HPV16 proteins, may harbor a biologically relevant HPV16 infection.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lang Kuhs, Kryst ...
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Anantharaman, De ...
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Waterboer, Tim
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Johansson, Matti ...
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Brennan, Paul
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Michel, Angelika
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show more...
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Willhauck-Flecke ...
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Purdue, Mark P
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Holcátová, Ivana
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Ahrens, Wolfgang
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Lagiou, Pagona
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Polesel, Jerry
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Simonato, Lorenz ...
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Merletti, Franco
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Healy, Claire M
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Kjaerheim, Krist ...
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Conway, David I
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Macfarlane, Tati ...
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Thomson, Peter
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Castellsagué, Xa ...
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Znaor, Ariana
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Black, Amanda
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Huang, Wen-Yi
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Krogh, Vittorio
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Trichopoulou, An ...
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Bueno-de-Mesquit ...
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Clavel-Chapelon, ...
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Weiderpass, Elis ...
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Ekström, Johanna
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Riboli, Elio
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Tjønneland, Anne
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Sánchez, María-J ...
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Travis, Ruth C
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Hildesheim, Alla ...
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Pawlita, Michael
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Kreimer, Aimée R
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet