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Markers of fibrinol...
Markers of fibrinolysis may predict development of lower extremity arterial disease in patients with diabetes : A longitudinal prospective cohort study with 10 years of follow-up
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- Rautio, Aslak, 1962- (författare)
- Umeå universitet,Medicin,Department of Medicine, Sunderby Hospital, Luleå, Sweden,Arcum,Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.;Sunderby Hosp, Dept Med, SE-97180 Lulea, Sweden.
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- Boman, Kurt (författare)
- Umeå universitet,Medicin,Research Unit, Skellefteå Hospital, Skellefteå, Sweden,Arcum,Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.;Skelleftea Hosp, Res Unit, Skelleftea, Sweden.
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- Eriksson, Jan W. (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Svensson, Maria K. (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism
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(creator_code:org_t)
- 2016-01-27
- 2016
- Engelska.
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Ingår i: Diabetes & Vascular Disease Research. - : SAGE Publications. - 1479-1641 .- 1752-8984. ; 13:3, s. 183-191
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: A previous cross-sectional study suggested that tissue plasminogen activator-activity might be an early marker of asymptomatic lower extremity arterial disease, but the long-term relationship is unknown.SUBJECTS AND METHODS: This study included 96 diabetic (48 type 1/48 type 2) and 62 non-diabetic subjects aged 30-70 years without previously known lower extremity arterial disease (age: 50.3 ± 9.3 years, gender: M/W 47.5/52.5% and body mass index: 26.6 ± 4.5 kg/m(2)). The relationships between asymptomatic lower extremity arterial disease and fibrinolytic markers (tissue plasminogen activator-activity, tissue plasminogen activator-mass, plasminogen activator inhibitor-1 activity) at baseline and after 10 years were assessed by logistic regression analysis adjusting for age, hypertension, statin treatment, HbA1c, triglycerides and low-density lipoprotein cholesterol as fixed covariates.RESULTS: The tissue plasminogen activator-activity at baseline and at the 10-year follow-up significantly predicted the presence of sign(s) of lower extremity arterial disease (odds ratio = 1.78, 95% confidence interval: 1.02-3.10, p = 0.043 and odds ratio = 1.78, 95% confidence interval: 1.12-2.23, p = 0.014, respectively). In addition, tissue plasminogen activator-mass at the 10-year follow-up was associated with signs of lower extremity arterial disease (odds ratio = 1.07, 95% confidence interval: 1.00-1.15, p = 0.046). Baseline age, hypertension and HbA1c were independently associated with sign(s) of lower extremity arterial disease at 10 years (odds ratio = 1.09, 95% confidence interval: 1.04-1.14, p = < 0.001; odds ratio = 3.68, 95% confidence interval: 1.67-8.12, p = 0.001 and odds ratio = 1.54, 95% confidence interval: 1.21-1.95, p = < 0.001, respectively).CONCLUSION: This long-term study supports previous findings of a significant association between asymptomatic lower extremity arterial disease and tissue plasminogen activator-activity. Thus, tissue plasminogen activator-activity may be an early marker of lower extremity arterial disease although the mechanism of this relationship remains unclear.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Fibrinolysis
- lower extremity arterial disease
- diabetes mellitus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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