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  • Innala, Lena,1060-Umeå universitet,Reumatologi (författare)

Co-morbidity in patients with early rheumatoid arthritis - inflammation matters

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • 2016-01-28
  • BioMed Central,2016
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-117189
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-117189URI
  • https://doi.org/10.1186/s13075-016-0928-yDOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Patients with rheumatoid arthritis (RA) suffer from co-morbidities that contribute to a shortened lifespan. Inflammation is important for the development of cardiovascular disease, but little is known on its relationship with other co-morbidities. We investigated the role of inflammation for the development of new comorbidities in early RA. Methods: Since 1995, all patients with early RA in Northern Sweden are included in a prospective study on comorbidities, with a total of 950 patients being included. At the time for this study, 726 had been ill for >= 5 years. Data on co-morbidities, clinical and laboratory disease activity and pharmacological therapy were collected from patient records and further validated using a questionnaire at RA onset (T0) and after 5 years (T5). Results: Of the patients, 53.2 % of the patients had one or more co-morbidity at onset, the commonest being: hypertension (27.3 %), obstructive pulmonary disease (13.9 %), diabetes (8.0 %), hypothyroidism (6.3 %) and malignancy (5.0 %). After 5 years, 41.0 % had developed at least one new co-morbidity, the most common being: hypertension (15.1 %), malignancy (7.6 %), stroke/transient ischemic accident (5.1 %), myocardial infarction (4.3 %) and osteoporosis (3.7 %). Age at disease onset, a raised erythrocyte sedimentation rate (ESR) at inclusion, previous treatment with glucocorticoids (GC; p < 0.001 for all), extra-articular RA (Ex-RA; p < 0.01), DAS28 (area under the curve) at 24 months (p < 0.05), previous smoking at inclusion (p = 0.058) and male gender (p < 0.01) were associated with a new co-morbidity overall at T5. Treatment with biologics (p < 0.05) reduced the risk. In multiple logistic regression modelling, ESR (p = 0.036) at inclusion was associated with a new co-morbidity after 5 years, adjusted for age, sex, smoking and GC treatment. In a similar model, Ex-RA (p < 0.05) was associated with a new co-morbidity at T5. In a third model, adjusted for age and sex, a new pulmonary co-morbidity was associated with a smoking history at inclusion (p < 0.01), but not with ESR. Conclusion: There was substantial co-morbidity among early RA patients already at disease onset, with considerable new co-morbidity being added during the first five years. Measures of disease activity were associated with the occurrence of a new co-morbidity indicating that the inflammation is of importance in this context.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Sjöberg, Clara,1986-Umeå universitet,Reumatologi(Swepub:umu)clsj0002 (författare)
  • Möller, Bozena (författare)
  • Ljung, Lotta,1964-Umeå universitet,Reumatologi(Swepub:umu)LJLO0001 (författare)
  • Smedby, Torgny (författare)
  • Södergren, Anna,1977-Umeå universitet,Reumatologi(Swepub:umu)anayxt97 (författare)
  • Magnusson, Staffan (författare)
  • Rantapää-Dahlqvist, Solbritt,1947-Umeå universitet,Reumatologi(Swepub:umu)sora0001 (författare)
  • Wållberg-Jonsson, Solveig,1953-Umeå universitet,Reumatologi(Swepub:umu)sowa0001 (författare)
  • Umeå universitetReumatologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Arthritis Research & Therapy: BioMed Central181478-6362

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