SwePub
Sök i LIBRIS databas

  Utökad sökning

(WFRF:(Cuadrado Godia Elisa))
 

Sökning: (WFRF:(Cuadrado Godia Elisa)) > DNA methylation and...

DNA methylation and stroke prognosis : an epigenome-wide association study

Jiménez-Balado, Joan (författare)
Hosp del Mar Res Inst, Dept Neurol, Neurovasc Res Grp, C Dr Aiguader 88, Barcelona 08003, Spain.
Fernández-Pérez, Isabel (författare)
Hosp del Mar Res Inst, Dept Neurol, Neurovasc Res Grp, C Dr Aiguader 88, Barcelona 08003, Spain.;Autonomous Univ Barcelona, Med Dept, Barcelona, Spain.
Gallego-Fábrega, Cristina (författare)
Inst Invest Biomed St Pau IIB ST PAU, St Quinti, Barcelona, Spain.
visa fler...
Lazcano, Uxue (författare)
Basque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC bioGUNE, Biscaia, Spain.
Soriano-Tárraga, Carolina (författare)
Washington Univ, Dept Psychiat NeuroGen & Informat, Sch Med, St. Louis, MO 63110 USA.
Vallverdú-Prats, Marta (författare)
Hosp del Mar Res Inst, Dept Neurol, Neurovasc Res Grp, C Dr Aiguader 88, Barcelona 08003, Spain.
Mola-Caminal, Marina (författare)
Uppsala universitet,Medicinsk epidemiologi
Rey-Álvarez, Lucía (författare)
Hosp del Mar Res Inst, Dept Neurol, Neurovasc Res Grp, C Dr Aiguader 88, Barcelona 08003, Spain.
Macias-Gómez, Adrià (författare)
Hosp del Mar Res Inst, Dept Neurol, Neurovasc Res Grp, C Dr Aiguader 88, Barcelona 08003, Spain.
Suárez-Pérez, Antoni (författare)
Hosp del Mar Res Inst, Dept Neurol, Neurovasc Res Grp, C Dr Aiguader 88, Barcelona 08003, Spain.
Giralt-Steinhauer, Eva (författare)
Hosp del Mar Res Inst, Dept Neurol, Neurovasc Res Grp, C Dr Aiguader 88, Barcelona 08003, Spain.
Rodríguez-Campello, Ana (författare)
Hosp del Mar Res Inst, Dept Neurol, Neurovasc Res Grp, C Dr Aiguader 88, Barcelona 08003, Spain.;Univ Pompeu Fabra UPF, Med Dept, DCEXS, Barcelona 08002, Spain.
Cuadrado-Godia, Elisa (författare)
Hosp del Mar Res Inst, Dept Neurol, Neurovasc Res Grp, C Dr Aiguader 88, Barcelona 08003, Spain.;Univ Pompeu Fabra UPF, Med Dept, DCEXS, Barcelona 08002, Spain.
Ois, Ángel (författare)
Hosp del Mar Res Inst, Dept Neurol, Neurovasc Res Grp, C Dr Aiguader 88, Barcelona 08003, Spain.;Univ Pompeu Fabra UPF, Med Dept, DCEXS, Barcelona 08002, Spain.
Esteller, Manel (författare)
Josep Carreras Leukaemia Res Inst IJC, Canc Epigenet Grp, Barcelona, Catalonia, Spain.;Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain.;Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Catalonia, Spain.;Univ Barcelona UB, Sch Med & Hlth Sci, Physiol Sci Dept, Barcelona, Catalonia, Spain.
Roquer, Jaume (författare)
Hosp del Mar Res Inst, Dept Neurol, Neurovasc Res Grp, C Dr Aiguader 88, Barcelona 08003, Spain.
Fernández-Cadenas, Israel (författare)
Inst Invest Biomed St Pau IIB ST PAU, St Quinti, Barcelona, Spain.
Jiménez-Conde, Jordi (författare)
Hosp del Mar Res Inst, Dept Neurol, Neurovasc Res Grp, C Dr Aiguader 88, Barcelona 08003, Spain.;Univ Pompeu Fabra UPF, Med Dept, DCEXS, Barcelona 08002, Spain.
visa färre...
Hosp del Mar Res Inst, Dept Neurol, Neurovasc Res Grp, C Dr Aiguader 88, Barcelona 08003, Spain Hosp del Mar Res Inst, Dept Neurol, Neurovasc Res Grp, C Dr Aiguader 88, Barcelona 08003, Spain.;Autonomous Univ Barcelona, Med Dept, Barcelona, Spain. (creator_code:org_t)
BioMed Central (BMC), 2024
2024
Engelska.
Ingår i: Clinical Epigenetics. - : BioMed Central (BMC). - 1868-7083. ; 16:1
Relaterad länk:
https://doi.org/10.1...
visa fler...
https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background and aimsStroke is the leading cause of adult-onset disability. Although clinical factors influence stroke outcome, there is a significant variability among individuals that may be attributed to genetics and epigenetics, including DNA methylation (DNAm). We aimed to study the association between DNAm and stroke prognosis.Methods and resultsTo that aim, we conducted a two-phase study (discovery-replication and meta-analysis) in Caucasian patients with ischemic stroke from two independent centers (BasicMar [discovery, N = 316] and St. Pau [replication, N = 92]). Functional outcome was assessed using the modified Rankin Scale (mRS) at three months after stroke, being poor outcome defined as mRS > 2. DNAm was determined using the 450K and EPIC BeadChips in whole-blood samples collected within the first 24 h. We searched for differentially methylated positions (DMPs) in 370,344 CpGs, and candidates below p-value < 10–5 were subsequently tested in the replication cohort. We then meta-analyzed DMP results from both cohorts and used them to identify differentially methylated regions (DMRs).After doing the epigenome-wide association study, we found 29 DMPs at p-value < 10–5 and one of them was replicated: cg24391982, annotated to thrombospondin-2 (THBS2) gene (p-valuediscovery = 1.54·10–6; p-valuereplication = 9.17·10–4; p-valuemeta-analysis = 6.39·10–9). Besides, four DMRs were identified in patients with poor outcome annotated to zinc finger protein 57 homolog (ZFP57), Arachidonate 12-Lipoxygenase 12S Type (ALOX12), ABI Family Member 3 (ABI3) and Allantoicase (ALLC) genes (p-value < 1·10–9 in all cases).DiscussionPatients with poor outcome showed a DMP at THBS2 and four DMRs annotated to ZFP57, ALOX12, ABI3 and ALLC genes. This suggests an association between stroke outcome and DNAm, which may help identify new stroke recovery mechanisms.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Epigenetics
Stroke outcome
Thrombospondin-2
DNA methylation

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy