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Plasma carotenoids,...
Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort
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- Bakker, Marije F. (author)
- University Medical Center Utrecht
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- Peeters, Petra H. M. (author)
- University Medical Center Utrecht
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- Klaasen, Veronique M. (author)
- University Medical Center Utrecht
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- Bueno-de-Mesquita, H. Bas (author)
- University Medical Center Utrecht
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- Jansen, Eugene H. J. M. (author)
- National Institute for Public Health and the Environment (RIVM)
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- Ros, Martine M. (author)
- National Institute for Public Health and the Environment (RIVM)
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- Travier, Noemie (author)
- Catalan Institute of Oncology
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- Olsen, Anja (author)
- Danish Cancer Society
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- Tjønneland, Anne (author)
- Danish Cancer Society
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- Overvad, Kim (author)
- Aarhus University
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Rinaldi, Sabina (author)
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Romieu, Isabelle (author)
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Brennan, Paul (author)
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Boutron-Ruault, Marie-Christine (author)
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Perquier, Florence (author)
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Cadeau, Claire (author)
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Boeing, Heiner (author)
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Aleksandrova, Krasimira (author)
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Kaaks, Rudolf (author)
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Kühn, Tilman (author)
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Trichopoulou, Antonia (author)
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Lagiou, Pagona (author)
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Trichopoulos, Dimitrios (author)
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Vineis, Paolo (author)
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Krogh, Vittorio (author)
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Panico, Salvatore (author)
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Masala, Giovanna (author)
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Tumino, Rosario (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Skeie, Guri (author)
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Lund, Eiliv (author)
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Ramon Quirós, J. (author)
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Ardanaz, Eva (author)
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Navarro, Carmen (author)
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Amiano, Pilar (author)
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Sánchez, María-José (author)
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Buckland, Genevieve (author)
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- Ericson, Ulrika (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Sonestedt, Emily (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Nutritionsepidemiologi,Diabetes - Cardiovascular Disease,Lund University Research Groups,Nutrition Epidemiology
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- Johansson, Matthias (author)
- Umeå universitet,Enheten för biobanksforskning,International Agency for Research on Cancer, Lyon, France
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- Sund, Malin (author)
- Umeå universitet,Kirurgi
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Travis, Ruth C. (author)
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Key, Timothy J. (author)
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Riboli, Elio (author)
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van Gils, Carla H. (author)
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 103:2, s. 454-464
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Background: Carotenoids and vitamin C are thought to be associated with reduced cancer risk because of their antioxidative capacity.Objective: This study evaluated the associations of plasma carotenoid, retinol, tocopherol, and vitamin C concentrations and risk of breast cancer.Design: In a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort, 1502 female incident breast cancer cases were included, with an oversampling of premenopausal (n = 582) and estrogen receptor-negative (ER-) cases (n = 462). Controls (n = 1502) were individually matched to cases by using incidence density sampling. Prediagnostic samples were analyzed for alpha-carotene, beta-carotene, lycopene, lutein, zeaxanthin, beta-cryptoxanthin, retinol, alpha-tocopherol, gamma-tocopherol, and 454 vitamin C. Breast cancer risk was computed according to hormone receptor status and age at diagnosis (proxy for menopausal status) by using conditional logistic regression and was further stratified by smoking status, alcohol consumption, and body mass index (BMI). All statistical tests were 2-sided.Results: In quintile 5 compared with quintile 1, alpha-carotene (OR: 0.61; 95% CI: 0.39, 0.98) and beta-carotene (OR: 0.41; 95% CI: 0.26, 0.65) were inversely associated with risk of ER- breast tumors. The other analytes were not statistically associated with ER- breast cancer. For estrogen receptor-positive (ER+) tumors, no statistically significant associations were found. The test for heterogeneity between ER- and ER+ tumors was statistically significant only for beta-carotene (P-heterogeneity = 0.03). A higher risk of breast cancer was found for retinol in relation to ER-/progesterone receptor-negative tumors (OR: 2.37; 95% CI: 1.20, 4.67; P-heterogeneity with ER+/progesterone receptor positive = 0.06). We observed no statistically significant interaction between smoking, alcohol, or BMI and all investigated plasma analytes (based on tertile distribution).Conclusion: Our results indicate that higher concentrations of plasma beta-carotene and alpha-carotene are associated with lower breast cancer risk of ER tumors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- breast cancer
- EPIC
- antioxidants
- carotenoids
- plasma
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bakker, Marije F ...
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Peeters, Petra H ...
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Klaasen, Veroniq ...
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Bueno-de-Mesquit ...
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Jansen, Eugene H ...
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Ros, Martine M.
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show more...
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Travier, Noemie
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Olsen, Anja
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Tjønneland, Anne
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Overvad, Kim
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Rinaldi, Sabina
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Romieu, Isabelle
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Brennan, Paul
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Boutron-Ruault, ...
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Perquier, Floren ...
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Cadeau, Claire
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Boeing, Heiner
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Aleksandrova, Kr ...
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Kaaks, Rudolf
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Kühn, Tilman
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Trichopoulou, An ...
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Lagiou, Pagona
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Trichopoulos, Di ...
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Vineis, Paolo
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Krogh, Vittorio
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Panico, Salvator ...
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Masala, Giovanna
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Tumino, Rosario
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Weiderpass, Elis ...
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Skeie, Guri
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Lund, Eiliv
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Ramon Quirós, J.
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Ardanaz, Eva
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Navarro, Carmen
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Amiano, Pilar
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Sánchez, María-J ...
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Buckland, Genevi ...
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Ericson, Ulrika
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Sonestedt, Emily
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Johansson, Matth ...
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Sund, Malin
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Travis, Ruth C.
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Key, Timothy J.
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Khaw, Kay-Tee
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Wareham, Nick
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Riboli, Elio
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van Gils, Carla ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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American Journal ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet