Search: (WFRF:(Kaaks Rudolf)) srt2:(2015-2019) pers:(Weiderpass Elisabete) pers:(Quirós J. Ramón)
> (2016) >
Prospective associa...
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Stepien, MagdalenaInternational Agency for Research on Cancer, World Health Organization
(author)
Prospective association of liver function biomarkers with development of hepatobiliary cancers
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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Elsevier,2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-118263
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118263URI
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https://doi.org/10.1016/j.canep.2016.01.002DOI
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https://lup.lub.lu.se/record/8577561URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:132990082URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Introduction: Serum liver biomarkers (gamma-glutamyl transferase, GGT; alanine aminotransferase, ALT; aspartate aminotransferase, AST; alkaline phosphatase, ALP; total bilirubin) are used as indicators of liver disease, but there is currently little data on their prospective association with risk of hepatobiliary cancers. Methods: A nested-case control study was conducted within the prospective EPIC cohort (>520,000 participants, 10 European countries). After a mean 7.5 mean years of follow-up, 121 hepatocellular carcinoma (HCC), 34 intrahepatic bile duct (IHBC) and 131 gallbladder and biliary tract (GBTC) cases were identified and matched to 2 controls each. Circulating biomarkers were measured in serum taken at recruitment into the cohort, prior to cancer diagnosis. Multivariable adjusted conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95% CI). Results: In multivariable models, 1SD increase of each log-transformed biomarker was positively associated with HCC risk (OR(GGT) = 4.23, 95% CI: 2.72-6.59; OR(ALP) = 3.43, 95% CI: 2.31-5.10; OR(AST) = 3.00, 95% CI: 2.04-4.42; OR(ALT) = 2.69, 95% CI: 1.89-3.84; OR(Bilirubin) = 2.25, 95% CI: 1.58-3.20). Each liver enzyme (OR(GGT) = 4.98; 95% CI: 1.75-14.17; OR(AST) = 3.10, 95% CI: 1.04-9.30; OR(ALT) = 2.86, 95% CI: 1.26-6.48, OR(ALP) = 2.31, 95% CI: 1.10-4.86) but not bilirubin (OR(Bilirubin) = 1.46,95% CI: 0.85-2.51) showed a significant association with IHBC. Only ALP was significantly associated with GBTC risk (OR (ALP) = 1.59, 95% CI: 1.20-2.09). Conclusion: This study shows positive associations between circulating liver biomarkers in sera collected prior to cancer diagnoses and the risks of developing HCC or IHBC, but not GBTC.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Fedirko, VeronikaEmory University
(author)
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Duarte-Salles, TalitaInternational Agency for Research on Cancer, World Health Organization
(author)
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Ferrari, PietroInternational Agency for Research on Cancer, World Health Organization
(author)
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Freisling, HeinzInternational Agency for Research on Cancer, World Health Organization
(author)
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Trepo, ElisabethLaboratoire Lyon République
(author)
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Trichopoulou, AntoniaHellenic Health Foundation, Athens
(author)
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Bamia, ChristinaHellenic Health Foundation, Athens
(author)
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Weiderpass, ElisabeteKarolinska Institutet
(author)
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Olsen, AnjaDanish Cancer Society
(author)
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Tjonneland, Anne
(author)
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Overvad, Kim
(author)
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Boutron-Ruault, Marie-Christine
(author)
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Fagherazzi, Guy
(author)
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Racine, Antoine
(author)
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Kuehn, Tilman
(author)
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Kaaks, Rudolf
(author)
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Aleksandrova, Krasimira
(author)
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Boeing, Heiner
(author)
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Lagiou, Pagona
(author)
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Benetou, Vassiliki
(author)
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Trichopoulos, Dimitrios
(author)
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Palli, Domenico
(author)
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Grioni, Sara
(author)
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Tumino, Rosario
(author)
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Naccarati, Alessio
(author)
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Panico, Salvatore
(author)
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Bueno-de-Mesquita, H. Bas
(author)
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Peeters, Petra H.
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Lund, Eiliv
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Quiros, J. Ramon
(author)
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Napoles, Osmel Companioni
(author)
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Sanchez, Maria-Jose
(author)
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Dorronsoro, Miren
(author)
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Maria Huerta, Jose
(author)
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Ardanaz, Eva
(author)
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Ohlsson, BodilLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)kir-boh
(author)
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Sjöberg, KlasLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-ksj
(author)
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Werner, MårtenUmeå universitet,Medicin(Swepub:umu)manwer04
(author)
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Nyström, HannaUmeå universitet,Kirurgi
(author)
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Khaw, Kay-Tee
(author)
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Key, Timothy J.
(author)
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Gunter, Marc
(author)
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Cross, Amanda
(author)
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Riboli, Elio
(author)
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Romieu, Isabelle
(author)
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Jenab, Mazda
(author)
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International Agency for Research on Cancer, World Health OrganizationEmory University
(creator_code:org_t)
Related titles
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In:Cancer Epidemiology: Elsevier40, s. 179-1871877-78211877-783X
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Stepien, Magdale ...
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Fedirko, Veronik ...
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Duarte-Salles, T ...
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Ferrari, Pietro
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Freisling, Heinz
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Trepo, Elisabeth
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Trichopoulou, An ...
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Overvad, Kim
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Boutron-Ruault, ...
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Fagherazzi, Guy
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Racine, Antoine
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Kuehn, Tilman
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Kaaks, Rudolf
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Aleksandrova, Kr ...
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Boeing, Heiner
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Lagiou, Pagona
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Benetou, Vassili ...
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Tumino, Rosario
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Naccarati, Aless ...
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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Peeters, Petra H ...
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Lund, Eiliv
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Quiros, J. Ramon
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Napoles, Osmel C ...
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Sanchez, Maria-J ...
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Dorronsoro, Mire ...
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Maria Huerta, Jo ...
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Ardanaz, Eva
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Ohlsson, Bodil
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Sjöberg, Klas
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Werner, Mårten
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Nyström, Hanna
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Khaw, Kay-Tee
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Key, Timothy J.
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Gunter, Marc
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Cross, Amanda
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Riboli, Elio
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Romieu, Isabelle
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Cancer Epidemiol ...
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Umeå University
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Lund University
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Karolinska Institutet