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Association analysi...
Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes
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Franke, Lude (author)
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el Bannoudi, Hanane (author)
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Jansen, Diahann T. S. L. (author)
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Kok, Klaas (author)
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Trynka, Gosia (author)
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Diogo, Dorothee (author)
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Swertz, Morris (author)
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Fransen, Karin (author)
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Knevel, Rachel (author)
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Gutierrez-Achury, Javier (author)
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- Ärlestig, Lisbeth (author)
- Umeå universitet,Reumatologi
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Greenberg, Jeffrey D. (author)
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Kremer, Joel (author)
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Pappas, Dimitrios A. (author)
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Kanterakis, Alexandros (author)
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Weersma, Rinse K. (author)
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van der Helm-van Mil, Annette H. M. (author)
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Guryev, Viktor (author)
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- Rantapää-Dahlqvist, Solbritt (author)
- Umeå universitet,Reumatologi
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Gregersen, Peter K. (author)
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Plenge, Robert M. (author)
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Wijmenga, Cisca (author)
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Huizinga, Tom W-J (author)
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Ioan-Facsinay, Andreea (author)
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Toes, Rene E. M. (author)
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Zhernakova, Alexandra (author)
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(creator_code:org_t)
- 2015-05-13
- 2016
- English.
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In: European Journal of Human Genetics. - : Nature Publishing Group. - 1018-4813 .- 1476-5438. ; 24:2, s. 263-270
- Related links:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Segmental duplications (SDs) comprise about 5% of the human genome and are enriched for immune genes. SD loci often show copy numbers variations (CNV), which are difficult to tag with genotyping methods. CNV in the Fc gamma receptor region (FCGR) has been suggested to be associated with rheumatic diseases. The objective of this study was to delineate association of FCGR-CNV with rheumatoid arthritis (RA), coeliac disease and Inflammatory bowel disease incidence. We developed a method to accurately quantify CNV in SD loci based on the intensity values from the Immunochip platform and applied it to the FCGR locus. We determined the method's validity using three independent assays: segregation analysis in families, arrayCGH, and whole genome sequencing. Our data showed the presence of two separate CNVs in the FCGR locus. The first region encodes FCGR2A, FCGR3A and part of FCGR2C gene, the second encodes another part of FCGR2C, FCGR3B and FCGR2B. Analysis of CNV status in 4578 individuals with RA and 5457 controls indicated association of duplications in the FCGR3B gene in antibody-negative RA (P = 0.002, OR = 1.43). Deletion in FCGR3B was associated with increased risk of antibody-positive RA, consistently with previous reports (P = 0.023, OR = 1.23). A clear genotype-phenotype relationship was observed: CNV polymorphisms of the FCGR3A gene correlated to CD16A expression (encoded by FCGR3A) on CD8 T-cells. In conclusion, our method allows determining the CNV status of the FCGR locus, we identified association of CNV in FCGR3B to RA and showed a functional relationship between CNV in the FCGR3A gene and CD16A expression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Franke, Lude
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el Bannoudi, Han ...
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Jansen, Diahann ...
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Kok, Klaas
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Trynka, Gosia
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Diogo, Dorothee
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show more...
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Swertz, Morris
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Fransen, Karin
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Knevel, Rachel
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Gutierrez-Achury ...
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Ärlestig, Lisbet ...
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Greenberg, Jeffr ...
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Kremer, Joel
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Pappas, Dimitrio ...
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Kanterakis, Alex ...
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Weersma, Rinse K ...
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van der Helm-van ...
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Guryev, Viktor
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Rantapää-Dahlqvi ...
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Gregersen, Peter ...
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Plenge, Robert M ...
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Wijmenga, Cisca
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Huizinga, Tom W- ...
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Ioan-Facsinay, A ...
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Toes, Rene E. M.
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Zhernakova, Alex ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
- Articles in the publication
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European Journal ...
- By the university
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Umeå University