Association between plasma concentrations of linoleic acid-derived oxylipins and the perceived pain scores in an exploratory study in women with chronic neck pain

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Nording Malin L.) > Association between...

Hellström, FredrikHögskolan i Gävle,Arbetshälsovetenskap,Centrum för belastningsskadeforskning (författare)

Association between plasma concentrations of linoleic acid-derived oxylipins and the perceived pain scores in an exploratory study in women with chronic neck pain

Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

2016-02-25
Springer Science and Business Media LLC,2016
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:umu-118393
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118393URI
https://doi.org/10.1186/s12891-016-0951-9DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-20434URI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

Background: Chronic musculoskeletal pain may be associated with changes in the balance of algogenic and anti-nociceptive compounds, and such changes may be visible in plasma samples. We have undertaken an exploratory study to measure the levels of endocannabinoids, related N-acylethanolamines and oxylipins (primarily those derived from linoleic acid) in plasma samples from women with chronic neck pain (NP) and chronic widespread pain (CWP), and to investigate whether the observed levels are associated with the pain experienced by these women.Methods: Blood samples from 35 women with NP, 15 with CWP and 27 age-matched controls were analysed for the lipids using ultra performance liquid chromatography coupled to tandem mass spectrometry. Current pain (“NRSday”) and the average pain during the last week (“NRSweek”) were rated by the participants using a numerical rating scale.Results: There were no significant differences in the plasma concentrations of the fifteen lipids investigated between the women with pain and the controls. However, significant correlations were seen for the NP group between the NRSday scores and the plasma concentrations of the linoleic acid derivatives 9- and 13-hydroxy-octadecadienoic acid (Spearman’s rho values 0.51 [P = 0.0016]) and 0.53 [P = 0.0011], respectively).Conclusions: The data obtained in this exploratory study indicate that although no group differences are seen in plasma lipid concentrations, there is an association between the NRSday scores and the 9- and 13-hydroxy-octadecadienoic acid levels. Whether or not the association reflects a causality (i.e. that the circulating lipids contribute to the perceived pain of the pain participants), requires further investigation.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Annan hälsovetenskap hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Other Health Sciences hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Annan medicinsk bioteknologi hsv//swe
MEDICAL AND HEALTH SCIENCES Medical Biotechnology Other Medical Biotechnology hsv//eng
Musculoskeletal disorders
chronic neck pain
chronic widespread pain
endocannabinoids
N- ylethanolamines
oxylipins
9-hydroxy-10E
12Z-octadecadienoic acid
13-hydroxy-9Z
11E- tadecadienoic acid

Biuppslag (personer, institutioner, konferenser, titlar ...)

Gouveia-Figueira, SandraUmeå universitet,Kemiska institutionen,Farmakologi,Department of Chemistry, Umeå University, Umeå; Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå(Swepub:umu)sago0010 (författare)
Nording, Malin L.Umeå universitet,Farmakologi,Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå(Swepub:umu)mano0003 (författare)
Björklund, MartinHögskolan i Gävle,Umeå universitet,Institutionen för samhällsmedicin och rehabilitering,Department of Occupational and Public Health Sciences, Centre for Musculoskeletal Research, University of Gävle, Sweden,Arbetshälsovetenskap,Centrum för belastningsskadeforskning,Department of Community Medicine and Rehabilitation, Umeå University, Umeå(Swepub:hig)mbb (författare)
Fowler, Christopher J.Umeå universitet,Farmakologi,Department of Community Medicine and Rehabilitation, Umeå universitet, Umeå(Swepub:umu)chfo0001 (författare)
Högskolan i GävleArbetshälsovetenskap (creator_code:org_t)

Sammanhörande titlar

Ingår i:BMC Musculoskeletal Disorders: Springer Science and Business Media LLC171471-2474

Internetlänk

Hitta via bibliotek

BMC Musculoskeletal Disorders (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Hellström, Fredr ...; Gouveia-Figueira ...; Nording, Malin L ...; Björklund, Marti ...; Fowler, Christop ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Annan hälsoveten ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinsk biotek ...; och Annan medicinsk ...

Artiklar i publikationen: BMC Musculoskele ...

Av lärosätet: Umeå universitet; Högskolan i Gävle

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se