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Genetic susceptibil...
Genetic susceptibility to postherniotomy pain : the influence of polymorphisms in the Mu opioid receptor, TNF-α, GRIK3, GCH1, BDNF and CACNA2D2 genes
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- Kalliomäkia, Maija-Liisa (författare)
- Uppsala University, Department for Surgical Sciences, Uppsala, Sweden. Department of Anaesthesia, Tampere University Hospital, Finland
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- Sandblom, Gabriel (författare)
- Karolinska Institutet
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- Mathias, Hallberg (författare)
- Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Uppsala University, Uppsala, Sweden
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- Grönbladh, Alfhild (författare)
- Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Uppsala University, Uppsala, Sweden
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- Gunnarsson, Ulf (författare)
- Umeå universitet,Kirurgi
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- Gordh, Torsten (författare)
- Uppsala University, Department for Surgical Sciences, Uppsala, Sweden. Pain Centre, Uppsala University Hospital, Uppsala, Sweden
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- Ginya, Harumi (författare)
- Division of IVD System Development, Precision System Science Co., Ltd., Chiba, Japan
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- Nyberg, Fred (författare)
- Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Uppsala University, Uppsala, Sweden
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Karolinska Institutet Uppsala University, Department for Surgical Sciences, Uppsala, Sweden Department of Anaesthesia, Tampere University Hospital, Finland (creator_code:org_t)
- 2016-07-01
- 2016
- Engelska.
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Ingår i: Scandinavian Journal of Pain. - : Elsevier. - 1877-8860 .- 1877-8879. ; 12, s. 1-6
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background and aims: Despite improvements in surgical technique, 5%–8% of patients undergoing herniorrhaphy still suffer from clinically relevant persistent postherniotomy pain. This is a problem at both individual and society levels. The aim of this study was to determine whether or not a single nucleotide polymorphism in a specific gene contributes to the development of persistent pain after surgery.Methods: One hundred individuals with persistent postherniotomy pain, along with 100 without pain matched for age, gender and type of surgery were identified in a previous cohort study on patients operated for groin hernia. All patients underwent a thorough sensory examination and blood samples were collected. DNA was extracted and analysed for single nucleotide polymorphism in the Mu opioid receptor, TNF-α, GRIK3, GCH1, BDNF and CACNA2D2 genes.Results: Patients with neuropathic pain were found to have a homozygous single nucleotide polymorph in the TNF-α gene significantly more often than pain-free patients (P = 0.036, one-tailed test).Conclusions: SNP in the TNF-α gene has a significant impact on the risk for developing PPSP.Implications: The result suggests the involvement of genetic variance in the development of pain and this requires further investigation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Persistent postsurgical pain
- Single nucleotide polymorphism
- Genetic variance
- TNF-α
- Groin hernia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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