Search: (WFRF:(Gunter Marc J.)) pers:(Peeters Petra H) pers:(Palli Domenico)
> (2016) >
Acrylamide and glyc...
Acrylamide and glycidamide hemoglobin adduct levels and endometrial cancer risk : a nested case-control study in nonsmoking postmenopausal women from the EPIC cohort
-
Obón-Santacana, Mireia (author)
-
Freisling, Heinz (author)
-
Peeters, Petra H (author)
-
show more...
-
Lujan-Barroso, Leila (author)
-
Ferrari, Pietro (author)
-
Boutron-Ruault, Marie-Christine (author)
-
Mesrine, Sylvie (author)
-
Baglietto, Laura (author)
-
Turzanski-Fortner, Renee (author)
-
Katzke, Verena A (author)
-
Boeing, Heiner (author)
-
Quirós, J Ramón (author)
-
Molina-Portillo, Elena (author)
-
Larrañaga, Nerea (author)
-
Chirlaque, María-Dolores (author)
-
Barricarte, Aurelio (author)
-
Khaw, Kay-Tee (author)
-
Wareham, Nick (author)
-
Travis, Ruth C (author)
-
Merritt, Melissa A (author)
-
Gunter, Marc J (author)
-
Trichopoulou, Antonia (author)
-
Lagiou, Pagona (author)
-
Naska, Androniki (author)
-
Palli, Domenico (author)
-
Sieri, Sabina (author)
-
Tumino, Rosario (author)
-
Fiano, Valentina (author)
-
Galassom, Rocco (author)
-
Bueno-de-Mesquita, H B As (author)
-
Onland-Moret, N Charlotte (author)
-
- Idahl, Annika (author)
- Umeå universitet,Obstetrik och gynekologi,Näringsforskning
-
- Lundin, Eva (author)
- Umeå universitet,Patologi
-
- Weiderpass, Elisabete (author)
- Karolinska Institutet
-
Vesper, Hubert (author)
-
Riboli, Elio (author)
-
Duell, Eric J (author)
-
show less...
-
(creator_code:org_t)
- 2015-10-01
- 2016
- English.
-
In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 138:5, s. 1129-1138
- Related links:
-
https://onlinelibrar...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Acrylamide, classified in 1994 by IARC as "probably carcinogenic to humans," was discovered in 2002 in some heat-treated, carbohydrate-rich foods. Four prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The purpose of this nested case-control study, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, was to evaluate, for the first time, the association between hemoglobin adducts of acrylamide (HbAA) and glycidamide (HbGA) and the risk of developing EC in non-smoking postmenopausal women. Hemoglobin adducts were measured in red blood cells by HPLC/MS/MS. Four exposure variables were evaluated: HbAA, HbGA, their sum (HbAA+HbGA), and their ratio (HbGA/HbAA). The association between hemoglobin adducts and EC was evaluated using unconditional multivariable logistic regression models, and included 383 EC cases (171 were type-I EC), and 385 controls. Exposure variables were analyzed in quintiles based on control distributions. None of the biomarker variables had an effect on overall EC (HRHbAA;Q5vsQ1 : 0.84, 95%CI: 0.49-1.48; HRHbGA;Q5vsQ1 : 0.94, 95%CI: 0.54-1.63) or type-I EC risk. Additionally, none of the subgroups investigated (BMI < 25 vs. ≥25 kg m(-2) , alcohol drinkers vs. never drinkers, oral contraceptive users vs. non-users) demonstrated effect measure modification. Hemoglobin adducts of acrylamide or glycidamide were not associated with EC or type-I EC risk in 768 nonsmoking postmenopausal women from the EPIC cohort.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- hemoglobin adduct
- acrylamide
- glycidamide
- endometrial cancer
- EPIC
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Obón-Santacana, ...
-
Freisling, Heinz
-
Peeters, Petra H
-
Lujan-Barroso, L ...
-
Ferrari, Pietro
-
Boutron-Ruault, ...
-
show more...
-
Mesrine, Sylvie
-
Baglietto, Laura
-
Turzanski-Fortne ...
-
Katzke, Verena A
-
Boeing, Heiner
-
Quirós, J Ramón
-
Molina-Portillo, ...
-
Larrañaga, Nerea
-
Chirlaque, María ...
-
Barricarte, Aure ...
-
Khaw, Kay-Tee
-
Wareham, Nick
-
Travis, Ruth C
-
Merritt, Melissa ...
-
Gunter, Marc J
-
Trichopoulou, An ...
-
Lagiou, Pagona
-
Naska, Androniki
-
Palli, Domenico
-
Sieri, Sabina
-
Tumino, Rosario
-
Fiano, Valentina
-
Galassom, Rocco
-
Bueno-de-Mesquit ...
-
Onland-Moret, N ...
-
Idahl, Annika
-
Lundin, Eva
-
Weiderpass, Elis ...
-
Vesper, Hubert
-
Riboli, Elio
-
Duell, Eric J
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
International Jo ...
- By the university
-
Umeå University
-
Karolinska Institutet