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Cathepsin K Contrib...
Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis
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Kubler, Andre (author)
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- Larsson, Christer (author)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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Luna, Brian (author)
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Andrade, Bruno B. (author)
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Amaral, Eduardo P. (author)
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Urbanowski, Michael (author)
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Orandle, Marlene (author)
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Bock, Kevin (author)
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Ammerman, Nicole C. (author)
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Cheung, Laurene S. (author)
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Winglee, Kathryn (author)
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Halushka, Marc (author)
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Park, Jin Kyun (author)
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Sher, Alan (author)
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Friedland, Jon S. (author)
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Elkington, Paul T. (author)
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Bishai, William R. (author)
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(creator_code:org_t)
- 2015-09-27
- 2016
- English.
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In: Journal of Infectious Diseases. - : Oxford University Press. - 0022-1899 .- 1537-6613. ; 213:4, s. 618-627
- Related links:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Cavitation in tuberculosis enables highly efficient person-to-person aerosol transmission. We performed transcriptomics in the rabbit cavitary tuberculosis model. Among 17 318 transcripts, we identified 22 upregulated proteases. Five type I collagenases were overrepresented: cathepsin K (CTSK), mast cell chymase-1 (CMA1), matrix metalloproteinase 1 (MMP-1), MMP-13, and MMP-14. Studies of collagen turnover markers, specifically, collagen type I C-terminal propeptide (CICP), urinary deoxypyridinoline (DPD), and urinary helical peptide, revealed that cavitation in tuberculosis leads to both type I collagen destruction and synthesis and that proteases other than MMP-1, MMP-13, and MMP-14 are involved, suggesting a key role for CTSK. We confirmed the importance of CTSK upregulation in human lung specimens, using immunohistochemical analysis, which revealed perigranulomatous staining for CTSK, and we showed that CTSK levels were increased in the serum of patients with tuberculosis, compared with those in controls (3.3 vs 0.3 ng/mL; P = .005).
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- tuberculosis
- cathepsin K
- rabbit
- collagen
- collagenolysis
- RNAseq
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Kubler, Andre
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Larsson, Christe ...
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Luna, Brian
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Andrade, Bruno B ...
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Amaral, Eduardo ...
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Urbanowski, Mich ...
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show more...
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Orandle, Marlene
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Bock, Kevin
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Ammerman, Nicole ...
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Cheung, Laurene ...
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Winglee, Kathryn
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Halushka, Marc
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Park, Jin Kyun
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Sher, Alan
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Friedland, Jon S ...
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Elkington, Paul ...
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Bishai, William ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
- Articles in the publication
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Journal of Infec ...
- By the university
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Umeå University