Mallards and highly pathogenic avian influenza ancestral viruses, northern Europe

Munster, Vincent JErasmus Medical Center, Rotterdam, the Netherlands (författare)

Outbreaks of highly pathogenic avian influenza (HPAI), which originate in poultry upon transmission of low pathogenic viruses from wild birds, have occurred relatively frequently in the last decade. During our ongoing surveillance studies in wild birds, we isolated several influenza A viruses of hemagglutinin subtype H5 and H7 that contain various neuraminidase subtypes. For each of the recorded H5 and H7 HPAI outbreaks in Europe since 1997, our collection contained closely related virus isolates recovered from wild birds, as determined by sequencing and phylogenetic analyses of the hemagglutinin gene and antigenic characterization of the hemagglutinin glycoprotein. The minor genetic and antigenic diversity between the viruses recovered from wild birds and those causing HPAI outbreaks indicates that influenza A virus surveillance studies in wild birds can help generate prototypic vaccine candidates and design and evaluate diagnostic tests, before outbreaks occur in animals and humans.

Wallensten, AndersLinköpings universitet,Molekylär virologi,Hälsouniversitetet(Swepub:liu)andwa52 (författare)
Baas, ChantalErasmus Medical Center, Rotterdam, the Netherlands (författare)
Rimmelzwaan, Guus FErasmus Medical Center, Rotterdam, the Netherlands (författare)
Schutten, MartinErasmus Medical Center, Rotterdam, the Netherlands (författare)
Olsen, BjörnKalmar University, Kalmar, Sweden.,Umea University, Umea, Sweden (författare)
Osterhaus, Albert D M EErasmus Medical Center, Rotterdam, the Netherlands (författare)
Fouchier, Ron A MErasmus Medical Center, Rotterdam, the Netherlands (författare)
Erasmus Medical Center, Rotterdam, the NetherlandsMolekylär virologi (creator_code:org_t)

Ingår i:Emerging Infectious DiseasesAtlanta : Center of disease control11:10, s. 1545-15511080-60401080-6059

Av författaren/redakt...: Munster, Vincent ...; Wallensten, Ande ...; Baas, Chantal; Rimmelzwaan, Guu ...; Schutten, Martin; Olsen, Björn; visa fler...; Osterhaus, Alber ...; Fouchier, Ron A ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Infektionsmedici ...

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