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Systematic Review o...
Systematic Review of Surgical Management of Nonmetastatic Renal Cell Carcinoma with Vena Caval Thrombus
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- Lardas, Michael (författare)
- Aberdeen Royal Infirmary
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- Stewart, Fiona (författare)
- University of Aberdeen
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- Scrimgeour, Duncan (författare)
- Aberdeen Royal Infirmary
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Hofmann, Fabian (författare)
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Marconi, Lorenzo (författare)
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- Dabestani, Saeed (författare)
- Lund University,Lunds universitet,Urologi,Forskargrupper vid Lunds universitet,Urology,Lund University Research Groups,Skåne University Hospital
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Bex, Axel (författare)
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Volpe, Alessandro (författare)
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Canfield, Steven E (författare)
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Staehler, Michael (författare)
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Hora, Milan (författare)
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Powles, Thomas (författare)
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Merseburger, Axel S (författare)
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Kuczyk, Markus A (författare)
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Bensalah, Karim (författare)
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Mulders, Peter F A (författare)
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- Ljungberg, Börje (författare)
- Umeå universitet,Urologi och andrologi
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Lam, Thomas B L (författare)
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: European Urology. - : Elsevier BV. - 0302-2838 .- 1873-7560. ; 70:2, s. 265-280
- Relaterad länk:
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http://hdl.handle.ne...
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- CONTEXT: Overall, 4-10% of patients with renal cell carcinoma (RCC) present with venous tumour thrombus. It is uncertain which surgical technique is best for these patients. Appraisal of outcomes with differing techniques would guide practice.OBJECTIVE: To systematically review relevant literature comparing the outcomes of different surgical therapies and approaches in treating vena caval thrombus (VCT) from nonmetastatic RCC.EVIDENCE ACQUISITION: Relevant databases (Medline, Embase, and the Cochrane Library) were searched to identify relevant comparative studies. Risk of bias and confounding assessments were performed. A narrative synthesis of the evidence was presented.EVIDENCE SYNTHESIS: The literature search identified 824 articles. Fourteen studies reporting on 2262 patients were included. No distinct surgical method was superior for the excision of VCT, although the method appeared to be dependent on tumour thrombus level. Minimal access techniques appeared to have better perioperative and recovery outcomes than traditional median sternotomy, but the impact on oncologic outcomes is unknown. Preoperative renal artery embolisation did not offer any oncologic benefits and instead resulted in significantly worse perioperative and recovery outcomes, including possibly higher perioperative mortality. The comparison of cardiopulmonary bypass versus no cardiopulmonary bypass showed no differences in oncologic outcomes. Overall, there were high risks of bias and confounding.CONCLUSIONS: The evidence base, although derived from retrospective case series and complemented by expert opinion, suggests that patients with nonmetastatic RCC and VCT and acceptable performance status should be considered for surgical intervention. Despite a robust review, the findings were associated with uncertainty due to the poor quality of primary studies available. The most efficacious surgical technique remains unclear.PATIENT SUMMARY: We examined the literature on the benefits of surgery to remove kidney cancers that have spread to neighbouring veins. The results suggest such surgery, although challenging and associated with high risk of complications, appears to be feasible and effective and should be contemplated for suitable patients if possible; however, many uncertainties remain due to the poor quality of the data.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Nonmetastatic renal cell carcinoma
- Vena caval thrombus
- Surgical management of tumour thrombus
- Thrombectomy
- Circulatory bypass and preoperative embolisation
- Systematic review
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lardas, Michael
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Stewart, Fiona
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Scrimgeour, Dunc ...
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Hofmann, Fabian
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Marconi, Lorenzo
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Dabestani, Saeed
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visa fler...
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Bex, Axel
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Volpe, Alessandr ...
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Canfield, Steven ...
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Staehler, Michae ...
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Hora, Milan
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Powles, Thomas
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Merseburger, Axe ...
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Kuczyk, Markus A
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Bensalah, Karim
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Mulders, Peter F ...
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Ljungberg, Börje
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Lam, Thomas B L
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
- Artiklar i publikationen
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European Urology
- Av lärosätet
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Umeå universitet
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Lunds universitet