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Accelerated decline in white matter integrity in clinically normal individuals at risk for Alzheimer's disease

Rieckmann, Anna (author)
Umeå universitet,Diagnostisk radiologi,Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
Van Dijk, Koene R. A. (author)
Sperling, Reisa A. (author)
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Johnson, Keith A. (author)
Buckner, Randy L. (author)
Hedden, Trey (author)
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 (creator_code:org_t)
Elsevier BV, 2016
2016
English.
In: Neurobiology of Aging. - : Elsevier BV. - 0197-4580 .- 1558-1497. ; 42, s. 177-188
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Prior studies have identified white matter abnormalities in Alzheimer's disease (AD). Yet, cross-sectional studies in normal older individuals show little evidence for an association between markers of AD risk (APOE4 genotype and amyloid deposition), and white matter integrity. Here, 108 normal older adults (age, 66-87) with assessments of apolipoprotein e4 (APOE4) genotype and assessment of amyloid burden by positron emission tomography underwent diffusion tensor imaging scans for measuring white matter integrity at 2 time points, on average 2.6 years apart. Linear mixed-effects models showed that amyloid burden at baseline was associated with steeper decline in fractional anisotropy in the parahippocampal cingulum (p < 0.05). This association was not significant between baseline measures suggesting that longitudinal analyses can provide novel insights that are not detectable in cross-sectional designs. Amyloid-related changes in hippocampus volume did not explain the association between amyloid burden and change in fractional anisotropy. The results suggest that accumulation of cortical amyloid and white matter changes in parahippocampal cingulum are not independent processes in individuals at increased risk for AD.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Keyword

Aging
Amyloid
Diffusion tensor imaging
Longitudinal
White matter

Publication and Content Type

ref (subject category)
art (subject category)

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