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Female chromosome X...
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
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Machiela, Mitchell J (author)
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Zhou, Weiyin (author)
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Karlins, Eric (author)
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show more...
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Sampson, Joshua N (author)
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Freedman, Neal D (author)
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Yang, Qi (author)
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Hicks, Belynda (author)
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Dagnall, Casey (author)
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Hautman, Christopher (author)
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Jacobs, Kevin B (author)
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Abnet, Christian C (author)
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Aldrich, Melinda C (author)
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Amos, Christopher (author)
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Amundadottir, Laufey T (author)
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Arslan, Alan A (author)
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Beane-Freeman, Laura E (author)
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Berndt, Sonja I (author)
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Black, Amanda (author)
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Blot, William J (author)
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Bock, Cathryn H (author)
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Bracci, Paige M (author)
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Brinton, Louise A (author)
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Bueno-de-Mesquita, H Bas (author)
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Burdett, Laurie (author)
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Buring, Julie E (author)
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Butler, Mary A (author)
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Canzian, Federico (author)
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Carreón, Tania (author)
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Chaffee, Kari G (author)
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Chang, I-Shou (author)
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Chatterjee, Nilanjan (author)
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Chen, Chu (author)
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Chen, Constance (author)
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Chen, Kexin (author)
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Chung, Charles C (author)
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Cook, Linda S (author)
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Crous Bou, Marta (author)
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Cullen, Michael (author)
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Davis, Faith G (author)
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De Vivo, Immaculata (author)
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Ding, Ti (author)
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Doherty, Jennifer (author)
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Duell, Eric J (author)
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Epstein, Caroline G (author)
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Fan, Jin-Hu (author)
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Figueroa, Jonine D (author)
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Fraumeni, Joseph F (author)
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Friedenreich, Christine M (author)
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Fuchs, Charles S (author)
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Gallinger, Steven (author)
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Gao, Yu-Tang (author)
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Gapstur, Susan M (author)
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Garcia-Closas, Montserrat (author)
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Gaudet, Mia M (author)
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Gaziano, J Michael (author)
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Giles, Graham G (author)
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Gillanders, Elizabeth M (author)
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Giovannucci, Edward L (author)
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Goldin, Lynn (author)
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Goldstein, Alisa M (author)
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Haiman, Christopher A (author)
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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Hankinson, Susan E (author)
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Harris, Curtis C (author)
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- Henriksson, Roger (author)
- Umeå universitet,Onkologi
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Holly, Elizabeth A (author)
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Hong, Yun-Chul (author)
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Hoover, Robert N (author)
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Hsiung, Chao A (author)
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Hu, Nan (author)
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Hu, Wei (author)
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Hunter, David J (author)
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Hutchinson, Amy (author)
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Jenab, Mazda (author)
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Johansen, Christoffer (author)
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Khaw, Kay-Tee (author)
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Kim, Hee Nam (author)
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Kim, Yeul Hong (author)
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Kim, Young Tae (author)
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Klein, Alison P (author)
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Klein, Robert (author)
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Koh, Woon-Puay (author)
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Kolonel, Laurence N (author)
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Kooperberg, Charles (author)
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Kraft, Peter (author)
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Krogh, Vittorio (author)
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Kurtz, Robert C (author)
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LaCroix, Andrea (author)
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Lan, Qing (author)
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Landi, Maria Teresa (author)
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Marchand, Loic Le (author)
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Li, Donghui (author)
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Liang, Xiaolin (author)
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Liao, Linda M (author)
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Lin, Dongxin (author)
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Liu, Jianjun (author)
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Lissowska, Jolanta (author)
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Lu, Lingeng (author)
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Magliocco, Anthony M (author)
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Malats, Nuria (author)
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Matsuo, Keitaro (author)
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McNeill, Lorna H (author)
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McWilliams, Robert R (author)
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- Melin, Beatrice S (author)
- Umeå universitet,Onkologi
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Mirabello, Lisa (author)
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Moore, Lee (author)
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Olson, Sara H (author)
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Orlow, Irene (author)
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Park, Jae Yong (author)
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Patiño-Garcia, Ana (author)
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Peplonska, Beata (author)
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Peters, Ulrike (author)
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Petersen, Gloria M (author)
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Pooler, Loreall (author)
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Prescott, Jennifer (author)
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Prokunina-Olsson, Ludmila (author)
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Purdue, Mark P (author)
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Qiao, You-Lin (author)
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Rajaraman, Preetha (author)
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Real, Francisco X (author)
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Riboli, Elio (author)
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Risch, Harvey A (author)
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Rodriguez-Santiago, Benjamin (author)
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Ruder, Avima M (author)
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Savage, Sharon A (author)
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Schumacher, Fredrick (author)
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Schwartz, Ann G (author)
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Schwartz, Kendra L (author)
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Seow, Adeline (author)
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Wendy Setiawan, Veronica (author)
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Severi, Gianluca (author)
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Shen, Hongbing (author)
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Sheng, Xin (author)
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Shin, Min-Ho (author)
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Shu, Xiao-Ou (author)
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Silverman, Debra T (author)
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Spitz, Margaret R (author)
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Stevens, Victoria L (author)
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Stolzenberg-Solomon, Rachael (author)
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Stram, Daniel (author)
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Tang, Ze-Zhong (author)
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Taylor, Philip R (author)
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Teras, Lauren R (author)
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Tobias, Geoffrey S (author)
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Van Den Berg, David (author)
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Visvanathan, Kala (author)
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Wacholder, Sholom (author)
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Wang, Jiu-Cun (author)
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Wang, Zhaoming (author)
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Wentzensen, Nicolas (author)
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Wheeler, William (author)
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White, Emily (author)
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Wiencke, John K (author)
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Wolpin, Brian M (author)
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Wong, Maria Pik (author)
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Wu, Chen (author)
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Wu, Tangchun (author)
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Wu, Xifeng (author)
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Wu, Yi-Long (author)
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Wunder, Jay S (author)
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Xia, Lucy (author)
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Yang, Hannah P (author)
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Yang, Pan-Chyr (author)
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Yu, Kai (author)
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Zanetti, Krista A (author)
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Zeleniuch-Jacquotte, Anne (author)
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Zheng, Wei (author)
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Zhou, Baosen (author)
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Ziegler, Regina G (author)
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Perez-Jurado, Luis A (author)
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Caporaso, Neil E (author)
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Rothman, Nathaniel (author)
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Tucker, Margaret (author)
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Dean, Michael C (author)
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Yeager, Meredith (author)
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Chanock, Stephen J (author)
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(creator_code:org_t)
- 2016-06-13
- 2016
- English.
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In: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 7
- Related links:
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https://www.nature.c...
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show more...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events >2 Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. X mosaicism frequency increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and autosomes. Methylation array analyses of 33 women with X mosaicism indicate events preferentially involve the inactive X chromosome. Our results provide further evidence that the sex chromosomes undergo mosaic events more frequently than autosomes, which could have implications for understanding the underlying mechanisms of mosaic events and their possible contribution to risk for chronic diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Biological sciences
- Cancer
- Genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Machiela, Mitche ...
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Zhou, Weiyin
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Karlins, Eric
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Sampson, Joshua ...
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Freedman, Neal D
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Yang, Qi
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show more...
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Hicks, Belynda
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Dagnall, Casey
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Hautman, Christo ...
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Jacobs, Kevin B
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Abnet, Christian ...
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Aldrich, Melinda ...
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Amos, Christophe ...
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Amundadottir, La ...
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Arslan, Alan A
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Beane-Freeman, L ...
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Berndt, Sonja I
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Black, Amanda
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Blot, William J
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Bock, Cathryn H
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Bracci, Paige M
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Brinton, Louise ...
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Bueno-de-Mesquit ...
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Burdett, Laurie
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Buring, Julie E
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Butler, Mary A
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Canzian, Federic ...
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Carreón, Tania
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Chaffee, Kari G
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Chang, I-Shou
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Chatterjee, Nila ...
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Chen, Chu
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Chen, Constance
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Chen, Kexin
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Chung, Charles C
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Cook, Linda S
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Crous Bou, Marta
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Cullen, Michael
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Davis, Faith G
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De Vivo, Immacul ...
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Ding, Ti
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Doherty, Jennife ...
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Duell, Eric J
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Epstein, Carolin ...
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Fan, Jin-Hu
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Figueroa, Jonine ...
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Fraumeni, Joseph ...
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Friedenreich, Ch ...
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Fuchs, Charles S
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Gallinger, Steve ...
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Gao, Yu-Tang
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Gapstur, Susan M
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Garcia-Closas, M ...
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Gaudet, Mia M
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Gaziano, J Micha ...
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Giles, Graham G
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Gillanders, Eliz ...
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Giovannucci, Edw ...
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Goldin, Lynn
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Goldstein, Alisa ...
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Haiman, Christop ...
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Hallmans, Göran
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Hankinson, Susan ...
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Harris, Curtis C
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Henriksson, Roge ...
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Holly, Elizabeth ...
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Hong, Yun-Chul
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Hoover, Robert N
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Hsiung, Chao A
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Hu, Nan
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Hu, Wei
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Hunter, David J
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Hutchinson, Amy
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Jenab, Mazda
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Johansen, Christ ...
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Khaw, Kay-Tee
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Kim, Hee Nam
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Kim, Yeul Hong
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Kim, Young Tae
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Klein, Alison P
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Klein, Robert
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Koh, Woon-Puay
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Kolonel, Laurenc ...
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Kooperberg, Char ...
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Kraft, Peter
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Krogh, Vittorio
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Kurtz, Robert C
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LaCroix, Andrea
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Lan, Qing
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Landi, Maria Ter ...
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Marchand, Loic L ...
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Li, Donghui
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Liang, Xiaolin
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Liao, Linda M
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Lin, Dongxin
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Liu, Jianjun
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Lissowska, Jolan ...
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Lu, Lingeng
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Magliocco, Antho ...
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Malats, Nuria
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Matsuo, Keitaro
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McNeill, Lorna H
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McWilliams, Robe ...
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Melin, Beatrice ...
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Mirabello, Lisa
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Moore, Lee
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Olson, Sara H
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Orlow, Irene
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Park, Jae Yong
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Patiño-Garcia, A ...
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Peplonska, Beata
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Peters, Ulrike
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Petersen, Gloria ...
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Pooler, Loreall
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Prescott, Jennif ...
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Prokunina-Olsson ...
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Purdue, Mark P
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Qiao, You-Lin
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Rajaraman, Preet ...
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Real, Francisco ...
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Riboli, Elio
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Risch, Harvey A
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Rodriguez-Santia ...
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Ruder, Avima M
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Savage, Sharon A
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Schumacher, Fred ...
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Schwartz, Ann G
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Schwartz, Kendra ...
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Seow, Adeline
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Wendy Setiawan, ...
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Severi, Gianluca
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Shen, Hongbing
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Sheng, Xin
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Shin, Min-Ho
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Shu, Xiao-Ou
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Silverman, Debra ...
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Spitz, Margaret ...
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Stevens, Victori ...
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Stolzenberg-Solo ...
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Stram, Daniel
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Tang, Ze-Zhong
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Taylor, Philip R
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Teras, Lauren R
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Tobias, Geoffrey ...
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Van Den Berg, Da ...
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Visvanathan, Kal ...
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Wacholder, Sholo ...
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Wang, Jiu-Cun
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Wang, Zhaoming
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Wentzensen, Nico ...
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Wheeler, William
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White, Emily
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Wiencke, John K
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Wolpin, Brian M
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Wong, Maria Pik
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Wu, Chen
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Wu, Tangchun
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Wu, Xifeng
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Wu, Yi-Long
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Wunder, Jay S
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Xia, Lucy
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Yang, Hannah P
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Yang, Pan-Chyr
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Yu, Kai
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Zanetti, Krista ...
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Zeleniuch-Jacquo ...
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Zheng, Wei
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Zhou, Baosen
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Ziegler, Regina ...
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Perez-Jurado, Lu ...
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Caporaso, Neil E
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Rothman, Nathani ...
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Tucker, Margaret
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Dean, Michael C
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Yeager, Meredith
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Chanock, Stephen ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Communica ...
- By the university
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Umeå University