WFRF:(Hansson Anita C)
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- Strömberg, IngridUmeå universitet,Histologi med cellbiologi (author)
c-fos antisense oligonucleotides increase firing rate of striatal neurons in the anaesthetized rat.
- Article/chapterEnglish2004
Publisher, publication year, extent ...
- Elsevier BV,2004
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-12256
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-12256URI
- https://doi.org/10.1016/j.brainres.2003.10.061DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1943886URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Extracellular electrophysiological recordings were used to study the firing rate of striatal neurons before and up to 4 h after intrastriatal c-fos antisense oligonucleotide injections in urethane-anesthetized rats. A four-fold increase from baseline neuronal activity was observed between 1 and 3 h upon antisense treatment, but not after control oligonucleotide injections. We conclude that, under urethane anesthesia, which here does not affect c-fos expression in the striatum by itself, neuronal activity appears to be tonically suppressed by basal striatal c-fos expression.
Subject headings and genre
- Action Potentials/drug effects/*genetics
- Anesthesia
- Animals
- Corpus Striatum/drug effects/*physiology
- Genes; fos/drug effects/*genetics
- Male
- Neurons/drug effects/*physiology
- Oligonucleotides; Antisense/*pharmacology
- Rats
- Rats; Sprague-Dawley
Added entries (persons, corporate bodies, meetings, titles ...)
- Hansson, Anita C (author)
- Rimondini, Roberto (author)
- Sommer, Wolfgang (author)
- Stromberg, F (author)
- Umeå universitetHistologi med cellbiologi (creator_code:org_t)
Related titles
- In:Brain Research: Elsevier BV1000:1-2, s. 192-40006-8993
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