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Reprogramming Tumor...
Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis
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- Georgoudaki, Anna-Maria (author)
- Karolinska Institutet
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Prokopec, Kajsa E. (author)
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- Boura, Vanessa F. (author)
- Karolinska Institutet
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Hellqvist, Eva (author)
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- Sohn, Silke (author)
- Karolinska Institutet
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Ostling, Jeanette (author)
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Dahan, Rony (author)
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- Harris, Robert A. (author)
- Karolinska Institutet
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- Rantalainen, Mattias (author)
- Karolinska Institutet
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Klevebring, Daniel (author)
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- Sund, Malin (author)
- Umeå universitet,Kirurgi
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Brage, Suzanne Egyhazi (author)
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- Fuxe, Jonas (author)
- Karolinska Institutet
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- Rolny, Charlotte (author)
- Karolinska Institutet
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Li, Fubin (author)
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Ravetch, Jeffrey V. (author)
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- Karlsson, Mikael C. I. (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 15:9, s. 2000-2011
- Related links:
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https://umu.diva-por... (primary) (Raw object)
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Tumors are composed of multiple cell types besides the tumor cells themselves, including innate immune cells such as macrophages. Tumor-associated macrophages (TAMs) are a heterogeneous population of myeloid cells present in the tumor microenvironment (TME). Here, they contribute to immunosuppression, enabling the establishment and persistence of solid tumors as well as metastatic dissemination. We have found that the pattern recognition scavenger receptor MARCO defines a subtype of suppressive TAMs and is linked to clinical outcome. An anti-MARCO monoclonal antibody was developed, which induces anti-tumor activity in breast and colon carcinoma, as well as in melanoma models through reprogramming-TAM-populations to a pro-inflammatory phenotype and increasing tumor immunogenicity. This anti-tumor activity is dependent on the inhibitory Fc-receptor, Fc gamma RIIB, and also enhances the efficacy of checkpoint therapy. These results demonstrate that immunotherapies using antibodies designed to modify myeloid cells of the TME represent a promising mode of cancer treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Georgoudaki, Ann ...
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Prokopec, Kajsa ...
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Boura, Vanessa F ...
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Hellqvist, Eva
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Sohn, Silke
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Ostling, Jeanett ...
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show more...
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Dahan, Rony
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Harris, Robert A ...
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Rantalainen, Mat ...
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Klevebring, Dani ...
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Sund, Malin
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Brage, Suzanne E ...
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Fuxe, Jonas
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Rolny, Charlotte
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Li, Fubin
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Ravetch, Jeffrey ...
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Karlsson, Mikael ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cell Reports
- By the university
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Umeå University
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Karolinska Institutet