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- Ramsauer, BerndUmeå universitet,Medicin,Department of Nephrology, Skaraborgs Hospital, 541 58 Skövde, Sweden (författare)
Skin- and Plasmaautofluorescence in hemodialysis with glucose-free or glucose-containing dialysate
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
- 2017-01-05
- Springer Science and Business Media LLC,2017
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:umu-125034
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125034URI
- https://doi.org/10.1186/s12882-016-0418-0DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- Background: Haemodialysis (HD) patients suffer from an increased risk of cardiovascular disease (CVD). Skinautofluorescence (SAF) is a strong marker for CVD. SAF indirectly measures tissue advanced glycation end products(AGE) being cumulative metabolites of oxidative stress and cytokine-driven inflammatory reactions. The dialysatesoften contain glucose.Methods: Autofluorescence of skin and plasma (PAF) were measured in patients on HD during standard treatment(ST) with a glucose-containing dialysate (n = 24). After that the patients were switched to a glucose-free dialysate(GFD) for a 2-week period. New measurements were performed on PAF and SAF after 1 week (M1) and 2 weeks(M2) using GFD. Nonparametric paired statistical analyses were performed between each two periods.Results: SAF after HD increased non-significantly by 1.2% while when a GFD was used during HD at M1, a decreaseof SAF by 5.2% (p = 0.002) was found. One week later (M2) the reduction of 1.6% after the HD was not significant(p = 0.33). PAF was significantly reduced during all HD sessions. Free and protein-bound PAF decreased similarlywhether glucose containing or GFD was used. The HD resulted in a reduction of the total PAF of approximately15%, the free compound of 20% and the protein bound of 10%. The protein bound part of PAF correspondedto approximately 56% of the total reduction. The protein bound concentrations after each HD showed thelowest value after 2 weeks using glucose-free dialysate (p < 0.05). The change in SAF could not be related to achange in PAF.Conclusions: When changing to a GFD, SAF was reduced by HD indicating that such measure may hamperthe accumulation and progression of deposits of AGEs to protein in tissue, and thereby also the developmentof CVD. Glucose-free dialysate needs further attention. Protein binding seems firm but not irreversible.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Urologi och njurmedicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Urology and Nephrology hsv//eng
- Haemodialysis
- Plasma autofluorescence
- Skin autofluorescence
- Glucose free dialysate
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Engels, Gerwin Erik (författare)
- Graaff, Reindert (författare)
- Sikole, Aleksandar (författare)
- Arsov, Stefan (författare)
- Stegmayr, BerndUmeå universitet,Medicin(Swepub:umu)best0006 (författare)
- Umeå universitetMedicin (creator_code:org_t)
Sammanhörande titlar
- Ingår i:BMC Nephrology: Springer Science and Business Media LLC181471-2369
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- Stegmayr, Bernd
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