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Short-term plastici...
Short-term plasticity in excitatory synapses of the rat medial preoptic nucleus.
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- Malinina, Evgenya (author)
- Umeå universitet,Fysiologi
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- Druzin, Michael (author)
- Umeå universitet,Fysiologi
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- Johansson, Staffan (author)
- Umeå universitet,Fysiologi
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- English.
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In: Brain Research. - : Elsevier BV. - 0006-8993. ; 1110:1, s. 128-35
- Related links:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The medial preoptic nucleus (MPN) regulates sexual behavior which is subject to experience-dependent modifications. Such modifications must depend on functional plasticity in the controlling neural circuits. Thus, MPN synapses are likely candidates for the site of alterations. The present work is a first systematic study of functional synaptic plasticity at glutamatergic synapses in the MPN. Short-term activity-dependent plasticity was investigated using a slice preparation from young male rats. The average efficacy of AMPA/kainate-receptor-mediated synaptic transmission was activity-dependent, showing a peak at a steady stimulation rate of 2 Hz. The variation in efficacy was attributed to mainly presynaptic factors since the average response amplitude was roughly paralleled by the response probability. Upon paired-pulse stimulation, paired-pulse facilitation as well as paired-pulse depression was observed. In some cases, paired-pulse facilitation as well as paired-pulse depression was recorded from an individual neuron depending on the interval between the paired stimuli. On average, paired-pulse facilitation was observed at intervals <500 ms, and paired-pulse depression at intervals in the range 1-4 s. The findings thus reveal complex activity-dependent short-term plasticity of the functional synaptic properties in the medial preoptic nucleus.
Keyword
- Animals
- Dose-Response Relationship; Radiation
- Electric Stimulation/methods
- Excitatory Postsynaptic Potentials/*physiology/radiation effects
- Neuronal Plasticity/*physiology
- Preoptic Area/*cytology
- Rats
- Rats; Sprague-Dawley
- Synapses/*physiology
- Time Factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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