The Pressure Difference between Eye and Brain Changes with Posture

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Eklund, AndersUmeå universitet,Institutionen för strålningsvetenskaper,Centrum för medicinsk teknik och fysik (CMTF) (author)

The Pressure Difference between Eye and Brain Changes with Posture

Article/chapterEnglish2016

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2016-07-15
Wiley,2016
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-126335
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-126335URI
https://doi.org/10.1002/ana.24713DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Objective: The discovery of a posture-dependent effect on the difference between intraocular pressure (IOP) and intracranial pressure (ICP) at the level of lamina cribrosa could have important implications for understanding glaucoma and idiopathic intracranial hypertension and could help explain visual impairments in astronauts exposed to microgravity. The aim of this study was to determine the postural influence on the difference between simultaneously measured ICP and IOP.Methods: Eleven healthy adult volunteers (age = 46 ± 10 years) were investigated with simultaneous ICP, assessed through lumbar puncture, and IOP measurements when supine, sitting, and in 9° head-down tilt (HDT). The trans–lamina cribrosa pressure difference (TLCPD) was calculated as the difference between the IOP and ICP. To estimate the pressures at the lamina cribrosa, geometrical distances were estimated from magnetic resonance imaging and used to adjust for hydrostatic effects.Results: The TLCPD (in millimeters of mercury) between IOP and ICP was 12.3 ± 2.2 for supine, 19.8 ± 4.6 for sitting, and 6.6 ± 2.5 for HDT. The expected 24-hour average TLCPD on earth—assuming 8 hours supine and 16 hours upright—was estimated to be 17.3mmHg. By removing the hydrostatic effects on pressure, a corresponding 24-hour average TLCPD in microgravity environment was simulated to be 6.7mmHg.Interpretation: We provide a possible physiological explanation for how microgravity can cause symptoms similar to those seen in patients with elevated ICP. The observed posture dependency of TLCPD also implies that assessment of the difference between IOP and ICP in upright position may offer new understanding of the pathophysiology of idiopathic intracranial hypertension and glaucoma.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Jóhannesson, GautiUmeå universitet,Oftalmiatrik(Swepub:umu)gaijon02 (author)
Johansson, EliasUmeå universitet,Farmakologi(Swepub:umu)elsjon02 (author)
Holmlund, PetterUmeå universitet,Institutionen för strålningsvetenskaper(Swepub:umu)peho0022 (author)
Qvarlander, SaraUmeå universitet,Institutionen för strålningsvetenskaper(Swepub:umu)saqv0003 (author)
Ambarki, KhalidUmeå universitet,Institutionen för strålningsvetenskaper(Swepub:umu)kham0001 (author)
Wåhlin, AndersUmeå universitet,Institutionen för strålningsvetenskaper,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)arswan02 (author)
Koskinen, Lars-Owe D.Umeå universitet,Farmakologi(Swepub:umu)lako0002 (author)
Malm, JanUmeå universitet,Klinisk neurovetenskap(Swepub:umu)jama0002 (author)
Umeå universitetInstitutionen för strålningsvetenskaper (creator_code:org_t)

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In:Annals of Neurology: Wiley80:2, s. 269-2760364-51341531-8249

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By the author/editor: Eklund, Anders; Jóhannesson, Gau ...; Johansson, Elias; Holmlund, Petter; Qvarlander, Sara; Ambarki, Khalid; show more...; Wåhlin, Anders; Koskinen, Lars-O ...; Malm, Jan; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

Articles in the publication: Annals of Neurol ...

By the university: Umeå University

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