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  • Del Gobbo, Liana C.Stanford University,Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA. (författare)

omega-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease Pooling Project of 19 Cohort Studies

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • American Medical Association (AMA),2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-126378
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-126378URI
  • https://doi.org/10.1001/jamainternmed.2016.2925DOI
  • https://lup.lub.lu.se/record/ab9753f3-d893-49fd-b866-6b4f3dbd2dfeURI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-304424URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • IMPORTANCE The role of omega-3 polyunsaturated fatty acids for primary prevention of coronary heart disease (CHD) remains controversial. Most prior longitudinal studies evaluated self-reported consumption rather than biomarkers. OBJECTIVE To evaluate biomarkers of seafood-derived eicosapentaenoic acid (EPA; 20: 5 omega-3), docosapentaenoic acid (DPA; 22: 5 omega-3), and docosahexaenoic acid (DHA; 22: 6 omega-3) and plant-derived alpha-linolenic acid (ALA; 18: 3 omega-3) for incident CHD. DATA SOURCES A global consortium of 19 studies identified by November 2014. STUDY SELECTION Available prospective (cohort, nested case-control) or retrospective studies with circulating or tissue omega-3 biomarkers and ascertained CHD. DATA EXTRACTION AND SYNTHESIS Each study conducted standardized, individual-level analysis using harmonized models, exposures, outcomes, and covariates. Findings were centrally pooled using random-effects meta-analysis. Heterogeneity was examined by age, sex, race, diabetes, statins, aspirin, omega-6 levels, and FADS desaturase genes. MAIN OUTCOMES AND MEASURES Incident total CHD, fatal CHD, and nonfatal myocardial infarction (MI). RESULTS The 19 studies comprised 16 countries, 45 637 unique individuals, and 7973 total CHD, 2781 fatal CHD, and 7157 nonfatal MI events, with omega-3 measures in total plasma, phospholipids, cholesterol esters, and adipose tissue. Median age at baseline was 59 years (range, 18-97 years), and 28 660 (62.8%) were male. In continuous (per 1-SD increase) multivariable-adjusted analyses, the omega-3 biomarkers ALA, DPA, and DHA were associated with a lower risk of fatal CHD, with relative risks (RRs) of 0.91 (95% CI, 0.84-0.98) for ALA, 0.90 (95% CI, 0.85-0.96) for DPA, and 0.90 (95% CI, 0.84-0.96) for DHA. Although DPA was associated with a lower risk of total CHD (RR, 0.94; 95% CI, 0.90-0.99), ALA (RR, 1.00; 95% CI, 0.95-1.05), EPA (RR, 0.94; 95% CI, 0.87-1.02), and DHA (RR, 0.95; 95% CI, 0.91-1.00) were not. Significant associations with nonfatal MI were not evident. Associations appeared generally stronger in phospholipids and total plasma. Restricted cubic splines did not identify evidence of nonlinearity in dose responses. CONCLUSIONS AND RELEVANCE On the basis of available studies of free-living populations globally, biomarker concentrations of seafood and plant-derived omega-3 fatty acids are associated with a modestly lower incidence of fatal CHD.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Imamura, FumiakiUniversity of Cambridge,Univ Cambridge, Sch Clin Med, Epidemiol Unit, Med Res Council,Inst Metab Sci, Cambridge, England. (författare)
  • Aslibekyan, StellaUniversity of Alabama,Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL USA. (författare)
  • Marklund, MattiUppsala universitet,Uppsala University,University of Washington,Florida International University,Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.,University of Minnesota,National University of Singapore,Klinisk nutrition och metabolism,Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.,Florida Int Univ, Benjamin Leon Ctr Geriatr Res & Educ, Miami, FL 33199 USA.,Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.,Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Natl Univ Singapore, Dept Med, Yong Loo Lin Sch Med, Singapore, Singapore.;Natl Univ Hlth Syst, Singapore, Singapore.(Swepub:uu)matma701 (författare)
  • Virtanen, Jyrki K.University of Eastern Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Joensuu, Finland. (författare)
  • Wennberg, MariaUmeå University,Umeå universitet,Näringsforskning,Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.(Swepub:umu)mawe0024 (författare)
  • Yakoob, Mohammad Y.Stanford University,Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA. (författare)
  • Chiuve, Stephanie E.Harvard University,Brigham & Womens Hosp, Dept Med, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA. (författare)
  • dela Cruz, LuicitoCanc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia. (författare)
  • Frazier-Wood, Alexis C.Baylor College of Medicine,ARS, USDA, Childrens Nutr Res Ctr, Baylor Coll Med, Houston, TX USA. (författare)
  • Fretts, Amanda M. (författare)
  • Guallar, EliseoJohns Hopkins Bloomberg School of Public Health,Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. (författare)
  • Matsumoto, ChisaBrigham and Women's Hospital / Harvard Medical School,Tokyo Med Univ, Div Cardiol, Tokyo, Japan.;Brigham & Womens Hosp, Div Aging, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA. (författare)
  • Prem, KieshaNational University of Singapore,Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore. (författare)
  • Tanaka, ToshNational Institute on Aging, United States,University of Minnesota,NIA, Translat Gerontol Branch, Bethesda, MD 20892 USA.,Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA. (författare)
  • Wu, Jason H. Y.University of Sydney,Univ Sydney, George Inst Global Hlth, Sydney Med Sch, Sydney, NSW, Australia. (författare)
  • Zhou, XiaUniversity of Minnesota,Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA. (författare)
  • Helmer, CatherineUniversity of Bordeaux,Inst Sante Publ Epidemiol & Dev, Inst Natl Sante & Rech Med, Ctr Inst Natl Sante & Rech Med Epidemiol Biostat, Bordeaux, France.;Univ Bordeaux, Inst Sante Publ Epidemiol & Dev, Ctr Inst Natl Sante & Rech Med Epidemiol Biostat, Bordeaux, France. (författare)
  • Ingelsson, ErikUppsala universitet,Uppsala University,Molekylär epidemiologi,Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA.(Swepub:uu)ering425 (författare)
  • Yuan, Jian-MinUniversity of Pittsburgh,Univ Pittsburgh, Div Canc Control & Populat Sci, Inst Canc, Pittsburgh, PA USA.;Univ Pittsburgh, Dept Epidemiol, Grad Sch Publ Hlth, Pittsburgh, PA 15261 USA. (författare)
  • Barberger-Gateau, PascaleUniversity of Bordeaux,Inst Sante Publ Epidemiol & Dev, Inst Natl Sante & Rech Med, Ctr Inst Natl Sante & Rech Med Epidemiol Biostat, Bordeaux, France.;Univ Bordeaux, Inst Sante Publ Epidemiol & Dev, Ctr Inst Natl Sante & Rech Med Epidemiol Biostat, Bordeaux, France. (författare)
  • Campos, HanniaHarvard University,Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA. (författare)
  • Chaves, Paulo H. M. (författare)
  • Djousse, LucBrigham and Women's Hospital / Harvard Medical School,Brigham & Womens Hosp, Div Aging, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA. (författare)
  • Giles, Graham G.Cancer Council Victoria (författare)
  • Gomez-Aracena, JoseUniversity of Malaga,Univ Malaga, Dept Prevent Med, Malaga, Spain. (författare)
  • Hodge, Allison M. (författare)
  • Hu, Frank B.Brigham and Women's Hospital / Harvard Medical School,Harvard Med Sch, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA. (författare)
  • Jansson, Jan-HåkanUmeå University,Umeå universitet,Medicin(Swepub:umu)jaja0006 (författare)
  • Johansson, IngegerdUmeå University,Umeå universitet,Institutionen för odontologi,Umea Univ, Dept Odontol, Umea, Sweden.(Swepub:umu)injo0003 (författare)
  • Khaw, Kay-TeeUniversity of Cambridge,Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England. (författare)
  • Koh, Woon-PuayDuke–NUS Medical School,Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.;Duke NUS Grad Med Sch Singapore, Singapore, Singapore. (författare)
  • Lemaitre, Rozenn N.University of Washington,Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA. (författare)
  • Lind, LarsUppsala universitet,Uppsala University,Kardiovaskulär epidemiologi(Swepub:uu)larslind (författare)
  • Luben, Robert N.University of Cambridge,Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England. (författare)
  • Rimm, Eric B.Brigham and Women's Hospital / Harvard Medical School,Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA. (författare)
  • Risérus, UlfUppsala universitet,Uppsala University,Klinisk nutrition och metabolism(Swepub:uu)ulfriser (författare)
  • Samieri, CeciliaUniversity of Bordeaux,Inst Sante Publ Epidemiol & Dev, Inst Natl Sante & Rech Med, Ctr Inst Natl Sante & Rech Med Epidemiol Biostat, Bordeaux, France.;Univ Bordeaux, Inst Sante Publ Epidemiol & Dev, Ctr Inst Natl Sante & Rech Med Epidemiol Biostat, Bordeaux, France. (författare)
  • Franks, Paul W.Lund University,Lunds universitet,Umeå universitet,Medicin,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.;Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, Lund, Sweden.(Swepub:lu)med-plf (författare)
  • Siscovick, David S.New York Academy of Medicine,New York Acad Med, New York, NY USA. (författare)
  • Stampfer, MeirBrigham and Women's Hospital / Harvard Medical School,Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA. (författare)
  • Steffen, Lyn M. (författare)
  • Steffen, Brian T. (författare)
  • Tsai, Michael Y.University of Minnesota,Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA. (författare)
  • van Dam, Rob M. (författare)
  • Voutilainen, SariUniversity of Eastern Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Joensuu, Finland. (författare)
  • Willett, Walter C.Brigham and Women's Hospital / Harvard Medical School,Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA. (författare)
  • Woodward, MarkUniversity of Oxford,Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.;Univ Sydney, George Inst Global Hlth, Sydney Med Sch, Sydney, NSW, Australia.;Univ Oxford, George Inst Global Hlth, Nuffield Dept Publ Hlth, Oxford, England. (författare)
  • Mozaffarian, DariushTufts University,Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA. (författare)
  • Stanford UniversityStanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:JAMA Internal Medicine: American Medical Association (AMA)176:8, s. 1155-11662168-61062168-6114

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