SwePub
Sök i LIBRIS databas

  Extended search

(WFRF:(Turzanski Fortner Renee))
 

Search: (WFRF:(Turzanski Fortner Renee)) > Circulating Osteopo...

  • Duarte-Salles, TalitaInstitut Universitari d’Investigació en Atenció Primària Jordi Gol (author)

Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-126502
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-126502URI
  • https://doi.org/10.1158/1940-6207.CAPR-15-0434DOI
  • https://lup.lub.lu.se/record/9d6ddd16-e3c6-42cf-abe5-44f8bbd4d98fURI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:134171421URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We previously identified osteopontin (OPN) as a promising marker for the early detection of hepatocellular carcinoma (HCC). In this study, we investigated the association between prediagnostic circulating OPN levels and HCC incidence in a large population-based cohort. A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. During a mean follow-up of 4.8 years, 100 HCC cases were identified. Each case was matched to two controls and OPN levels were measured in baseline plasma samples. Viral hepatitis, liver function, and a-fetoprotein (AFP) tests were also conducted. Conditional logistic regression models were used to calculate multivariable odds ratio (OR) and 95% confidence intervals (95% CI) for OPN levels in relation to HCC. Receiver operating characteristics curves were constructed to determine the discriminatory accuracy of OPN alone or in combination with other liver biomarkers in the prediction of HCC. OPN levels were positively associated with HCC risk (per 10% increment, ORmultivariable = 1.30; 95% CI, 1.14-1.48). The association was stronger among cases diagnosed within 2 years of follow-up. Adding liver function tests to OPN improved the discriminatory performance for subjects who developed HCC (AUC = 0.86). For cases diagnosed within 2 years, the combination of OPN and AFP was best able to predict HCC risk (AUC = 0.88). The best predictive model for HCC in this low-risk population is OPN in combination with liver function tests. Within 2 years of diagnosis, the combination of OPN and AFP best predicted HCC development, suggesting that measuring OPN and AFP could identify high-risk groups independently of a liver disease diagnosis.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Misra, SandeepUniversity of Texas (author)
  • Stepien, MagdalenaInternational Agency for Research on Cancer, World Health Organization (author)
  • Plymoth, AmelieKarolinska Institutet,Karolinska Institute (author)
  • Muller, DavidInternational Agency for Research on Cancer, World Health Organization (author)
  • Overvad, KimAarhus University (author)
  • Olsen, AnjaDanish Cancer Society (author)
  • Tjonneland, AnneDanish Cancer Society (author)
  • Baglietto, LauraUniversity of Melbourne (author)
  • Severi, GianlucaHuman Genetics Foundation (HuGeF) (author)
  • Boutron-Ruault, Marie-ChristineStabilite genetique et oncogenese (author)
  • Turzanski-Fortner, ReneeGerman Cancer Research Centre (author)
  • Kaaks, RudolfGerman Cancer Research Centre (author)
  • Boeing, HeinerGerman Institute of Human Nutrition,University of Malaya (author)
  • Aleksandrova, KrasimiraGerman Institute of Human Nutrition (author)
  • Trichopoulou, AntoniaNational and Kapodistrian University of Athens (author)
  • Lagiou, PagonaNational and Kapodistrian University of Athens (author)
  • Bamia, ChristinaNational and Kapodistrian University of Athens (author)
  • Pala, ValeriaIstituto Nazionale dei Tumori (author)
  • Palli, DomenicoCancer Research and Prevention Institute (ISPO) (author)
  • Mattiello, AmaliaUniversity of Naples Federico II (author)
  • Tumino, RosarioCivic and M.P Arezzo Hospital (author)
  • Naccarati, AlessioHuman Genetics Foundation (HuGeF) (author)
  • Bueno-de-Mesquita, H. B(as). (author)
  • Peeters, Petra H.Imperial College London (author)
  • Weiderpass, ElisabeteKarolinska Institutet (author)
  • Quiros, J. RamonPublic Health Directorate (author)
  • Agudo, AntonioBellvitge University Hospital-IDIBELL (author)
  • Sanchez-Cantalejo, EmilioCIBER Epidemiology and Public Health (CIBERESP) (author)
  • Ardanaz, EvaHealth Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)(Swepub:lu)extLU-05 (author)
  • Gavrila, DianaMurcia Regional Health Council (author)
  • Dorronsoro, MirenCIBER Epidemiology and Public Health (CIBERESP) (author)
  • Werner, MårtenUmeå University,Umeå universitet,Medicin(Swepub:umu)manwer04 (author)
  • Hemmingsson, OskarUmeå University,Umeå universitet,Kirurgi(Swepub:umu)osrhen96 (author)
  • Ohlsson, BodilLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kir-boh (author)
  • Sjöberg, KlasLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-ksj (author)
  • Wareham, Nicholas J.Addenbrooke's Hospital (author)
  • Khaw, Kay-TeeUniversity of Cambridge (author)
  • Bradbury, Kathryn E.University of Oxford (author)
  • Gunter, Marc J.Imperial College London (author)
  • Cross, Amanda J.Imperial College London,International Agency for Research on Cancer, World Health Organization (author)
  • Riboli, ElioImperial College London (author)
  • Jenab, Mazda (author)
  • Hainaut, PierreUniversity Grenoble Alpes (author)
  • Beretta, LauraUniversity of Texas (author)
  • Institut Universitari d’Investigació en Atenció Primària Jordi GolUniversity of Texas (creator_code:org_t)

Related titles

  • In:Cancer Prevention Research9:9, s. 758-7651940-62071940-6215

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view