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> (2015-2016) >
A Prospective Evalu...
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Terry, Kathryn L.Harvard University
(author)
A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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American Association for Cancer Research,2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-126738
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-126738URI
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https://doi.org/10.1158/1078-0432.CCR-16-0316DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:134224931URI
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https://lup.lub.lu.se/record/e91031e6-db61-4003-a924-49c959297fc3URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Purpose: About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate earlydetection biomarkers. Here we evaluate the most promising ovarian cancer screening biomarkers in prospectively collected samples from the European Prospective Investigation into Cancer and Nutrition study. Experimental Design: We measured CA125, HE4, CA72.4, and CA15.3 in 810 invasive epithelial ovarian cancer cases and 1,939 controls. We calculated the sensitivity at 95% and 98% specificity as well as area under the receiver operator curve (C-statistic) for each marker individually and in combination. In addition, we evaluated marker performance by stage at diagnosis and time between blood draw and diagnosis. Results: We observed the best discrimination between cases and controls within 6 months of diagnosis for CA125 (C-statistic = 0.92), then HE4 (0.84), CA72.4 (0.77), and CA15.3 (0.73). Marker performance declined with longer time between blood draw and diagnosis and for earlier staged disease. However, assessment of discriminatory ability at early stage was limited by small numbers. Combinations of markers performed modestly, but significantly better than any single marker. Conclusions: CA125 remains the single best marker for the early detection of invasive epithelial ovarian cancer, but can be slightly improved by combining with other markers. Identifying novel markers for ovarian cancer will require studies including larger numbers of early-stage cases.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Schock, HelenaGerman Cancer Research Centre
(author)
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Fortner, Renée T.German Cancer Research Centre
(author)
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Hüsing, AnikaGerman Cancer Research Centre
(author)
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Fichorova, Raina N.Brigham and Women's Hospital / Harvard Medical School
(author)
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Yamamoto, Hidemi S.Brigham and Women's Hospital / Harvard Medical School
(author)
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Vitonis, Allison F.Brigham and Women's Hospital / Harvard Medical School
(author)
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Johnson, TheronGerman Cancer Research Centre
(author)
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Overvad, KimAarhus University
(author)
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Tjønneland, AnneDanish Cancer Society
(author)
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Boutron-Ruault, Marie-Christine
(author)
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Mesrine, Sylvie
(author)
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Severi, Gianluca
(author)
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Dossus, Laure
(author)
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Rinaldi, Sabina
(author)
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Boeing, Heiner
(author)
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Benetou, Vassiliki
(author)
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Lagiou, Pagona
(author)
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Trichopoulou, Antonia
(author)
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Krogh, Vittorio
(author)
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Kuhn, Elisabetta
(author)
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Panico, Salvatore
(author)
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Bueno-de-Mesquita, H. Bas
(author)
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Onland-Moret, N. Charlotte
(author)
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Peeters, Petra H.
(author)
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Gram, Inger Torhild
(author)
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Weiderpass, ElisabeteKarolinska Institutet
(author)
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Duell, Eric J.
(author)
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Sanchez, Maria-Jose
(author)
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Ardanaz, Eva
(author)
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Etxezarreta, Nerea
(author)
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Navarro, Carmen
(author)
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Idahl, AnnikaUmeå universitet,Obstetrik och gynekologi(Swepub:umu)anid0002
(author)
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Lundin, EvaUmeå universitet,Patologi(Swepub:umu)evlu0001
(author)
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Jirström, KarinLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-kji
(author)
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Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)smi-jma
(author)
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Wareham, Nicholas J.
(author)
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Khaw, Kay-Tee
(author)
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Byrne, Karl Smith
(author)
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Travis, Ruth C.
(author)
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Gunter, Marc J.
(author)
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Merritt, Melissa A.
(author)
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Riboli, Elio
(author)
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Cramer, Daniel W.
(author)
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Kaaks, Rudolf
(author)
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Harvard UniversityGerman Cancer Research Centre
(creator_code:org_t)
Related titles
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In:Clinical Cancer Research: American Association for Cancer Research22:18, s. 4664-46751078-04321557-3265
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Terry, Kathryn L ...
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Schock, Helena
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Fortner, Renée T ...
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Hüsing, Anika
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Fichorova, Raina ...
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Yamamoto, Hidemi ...
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Vitonis, Allison ...
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Johnson, Theron
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Overvad, Kim
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Tjønneland, Anne
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Boutron-Ruault, ...
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Mesrine, Sylvie
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Severi, Gianluca
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Dossus, Laure
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Rinaldi, Sabina
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Boeing, Heiner
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Benetou, Vassili ...
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Lagiou, Pagona
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Trichopoulou, An ...
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Krogh, Vittorio
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Kuhn, Elisabetta
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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Onland-Moret, N. ...
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Peeters, Petra H ...
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Gram, Inger Torh ...
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Weiderpass, Elis ...
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Duell, Eric J.
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Sanchez, Maria-J ...
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Ardanaz, Eva
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Etxezarreta, Ner ...
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Navarro, Carmen
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Idahl, Annika
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Lundin, Eva
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Jirström, Karin
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Manjer, Jonas
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Wareham, Nichola ...
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Khaw, Kay-Tee
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Byrne, Karl Smit ...
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Travis, Ruth C.
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Gunter, Marc J.
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Merritt, Melissa ...
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Riboli, Elio
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Cramer, Daniel W ...
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Kaaks, Rudolf
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Clinical Cancer ...
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Umeå University
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Karolinska Institutet
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Lund University