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Fine-Scale Mapping ...
Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
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- Vigorito, Elena (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.
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- Kuchenbaecker, Karoline B. (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.,Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, 1515 Pressler St,CBP 5, Houston, TX USA.;Univ Texas MD Anderson Canc Ctr, Clin Canc Genet Program, 1515 Pressler St,CBP 5, Houston, TX USA.,IEO, Div Canc Prevent & Genet, Via Ripamonti 435, I-20141 Milan, Italy.
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- Beesley, Jonathan (author)
- QIMR Berghofer Med Res Inst, Dept Genet, Herston Rd, Brisbane, Qld 4029, Australia.
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- Adlard, Julian (author)
- Chapel Allerton Hosp, Yorkshire Reg Genet Serv, Leeds, W Yorkshire, England.
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- Agnarsson, Bjarni A. (author)
- Univ Hosp Landspitali, Dept Pathol, IS-101 Reykjavik, Iceland.;Univ Iceland, Sch Med, IS-101 Reykjavik, Iceland.
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- Andrulis, Irene L. (author)
- Karolinska Institutet,Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
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- Arun, Banu K. (author)
- Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Obstet & Gynaecol, Dresden, Germany.
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- Barjhoux, Laure (author)
- Ctr Leon Berard, Batiment Cheney D,28 Rue Laennec, Lyon, France.,Netherlands Canc Inst, Family Canc Clin, POB 90203, NL-1000 BE Amsterdam, Netherlands.
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- Belotti, Muriel (author)
- Inst Curie, Serv Geneit Oncol, 26 Rue Ulm, Paris 05, France.,Univ Ghent, Ctr Med Genet, De Pintelaan 185, B-9000 Ghent, Belgium.
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- Benitez, Javier (author)
- Spanish Natl Canc Ctr CNIO, Human Genet Grp, Madrid, Spain.;Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Program, Human Genotyping CEGEN Unit, Madrid, Spain.
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- Berger, Andreas (author)
- Med Univ Vienna, Dept OB GYN, Vienna, Austria.
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- Bojesen, Anders (author)
- Vejle Hosp, Dept Clin Genet, Kabbeltoft 25, Vejle, Denmark.
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- Bonanni, Bernardo (author)
- 1600 Div St,C415, San Francisco, CA 94143 USA.,Fox Chase Canc Ctr, Dept Clin Oncol, 333 Cottman Ave, Philadelphia, PA USA.
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- Brewer, Carole (author)
- Royal Devon & Exeter Hosp, Dept Clin Genet, Exeter, Devon, England.
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- Caldes, Trinidad (author)
- Hosp Clin San Carlos, IdISSC Inst Invest Sanitaria, Mol Oncol Lab, Martin Lagos S-N, Madrid, Spain.
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- Caligo, Maria A. (author)
- Univ Pisa, Dept Lab Med, Sect Genet Oncol, Pisa, Italy.;Univ Hosp Pisa, Pisa, Italy.
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- Campbell, Ian (author)
- Peter MacCallum Canc Ctr, Div Res, Locked Bag 1,ABeckett St, Melbourne, Vic 8006, Australia.
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Chan, Salina B. (author)
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- Claes, Kathleen B. M. (author)
- Veneto Inst Oncol IOV IRCCS, Immunol & Mol Oncol Unit, Via Gattamelata 64, Padua, Italy.
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- Cohn, David E. (author)
- Ohio State Univ, Columbus Canc Council GYN Oncol, 3651 Ridge Mill Dr, Columbus, OH 43026 USA.
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- Cook, Jackie (author)
- Sheffield Childrens Hosp, Sheffield Clin Genet Serv, Sheffield, S Yorkshire, England.
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Daly, Mary B. (author)
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- Damiola, Francesca (author)
- Ctr Leon Berard, Batiment Cheney D,28 Rue Laennec, Lyon, France.
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- Davidson, Rosemarie (author)
- South Glasgow Univ Hosp, Dept Clin Genet, Glasgow, Lanark, Scotland.
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- de Pauw, Antoine (author)
- Inst Curie, Serv Geneit Oncol, 26 Rue Ulm, Paris 05, France.
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- Delnatte, Capucine (author)
- ICO Ctr Rene Gauducheau, Unite Oncogenet, Blvd Jacques Monod, F-44805 St Herblain, France.
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- Diez, Orland (author)
- Vall Hebron Univ Hosp, VHIO, Oncogenet Grp, Passeig Vall Hebron 119-129, Barcelona, Spain.;Univ Autonoma Barcelona, Passeig Vall Hebron 119-129, Barcelona, Spain.
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- Domchek, Susan M. (author)
- Univ Penn, Dept Med, Abramson Canc Ctr, Perelman Sch Med, 3400 Civic Ctr Blvd, Philadelphia, PA 19104 USA.
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- Dumont, Martine (author)
- CHU, Quebec Res Ctr, Genom Ctr, 2705 Laurier Blvd, Quebec City, PQ, Canada.;Univ Laval, 2705 Laurier Blvd, Quebec City, PQ, Canada.
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- Durda, Katarzyna (author)
- Pomeranian Med Univ, Dept Genet & Pathol, Polabska 4, Szczecin, Poland.
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- Dworniczak, Bernd (author)
- Univ Munster, Inst Human Genet, Munster, Germany.
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- Easton, Douglas F. (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.,Natl Ctr Sci Res Demokritos, INRASTES Inst Nucl & Radiol Sci & Technol, Mol Diagnost Lab, Patriarchou Gregoriou & Neapoleos Str, Athens, Greece.
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- Eccles, Diana (author)
- Southampton Univ Hosp NHS Trust, Fac Med, Southampton, Hants, England.
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- Edwinsdotter Ardnor, Christina (author)
- Umeå universitet,Onkologi,Umea Univ, Dept Radiat Sci, Oncol, Umea, Sweden.
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- Eeles, Ros (author)
- Inst Canc Res, Oncogenet Team, Sutton, Surrey, England.;Royal Marsden NHS Fdn Trust, Sutton, Surrey, England.
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- Ejlertsen, Bent (author)
- Univ Copenhagen Hosp, Dept Oncol, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
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- Ellis, Steve (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Strangeways Res Lab, Cambridge, England.
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- Evans, D. Gareth (author)
- Univ Manchester, Cent Manchester Univ Hosp NHS Fdn Trust, Inst Human Dev, Genom Med,Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England.
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- Feliubadalo, Lidia (author)
- Catalan Inst Oncol, Hereditary Canc Program, Mol Diagnost Unit, IDIBELL Bellvitge Biomed Res Inst, Gran Via lHospitalet,199-203, Barcelona 08908, Spain.
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- Fostira, Florentia (author)
- Med Univ Vienna, Dept OB GYN, A-1090 Vienna, Austria.;Waehringer Guertel 18-20, A-1090 Vienna, Austria.
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- Foulkes, William D. (author)
- McGill Univ, Dept Human Genet, Program Canc Genet, Montreal, PQ, Canada.;McGill Univ, Dept Oncol, Montreal, PQ, Canada.
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- Friedman, Eitan (author)
- Chaim Sheba Med Ctr, Inst Human Genet, Susanne Levy Gertner Oncogenet Unit, IL-52621 Ramat Gan, Israel.;Tel Aviv Univ, Sackler Fac Med, IL-69978 Ramat Aviv, Israel.
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- Frost, Debra (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Strangeways Res Lab, Cambridge, England.
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- Gaddam, Pragna (author)
- Mem Sloane Kettering Canc Ctr, Clin Canc Genet Lab, New York, NY USA.
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- Ganz, Patricia A. (author)
- Jonsson Comprehens Canc Ctr, Div Canc Prevent & Control Res, UCLA Sch Med, 650 Charles Young Dr South,Room A2-125 HS, Los Angeles, CA 90095 USA.;Jonsson Comprehens Canc Ctr, Div Canc Prevent & Control Res, UCLA Sch Publ Hlth, 650 Charles Young Dr South,Room A2-125 HS, Los Angeles, CA 90095 USA.
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- Garber, Judy (author)
- Dana Farber Canc Inst, Canc Risk & Prevent Clin, 450 Brookline Ave, Boston, MA 02115 USA.
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- Garcia-Barberan, Vanesa (author)
- Hosp Clin San Carlos, IdISSC Inst Invest Sanitaria, Mol Oncol Lab, Martin Lagos S-N, Madrid, Spain.
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- Gauthier-Villars, Marion (author)
- Inst Curie, Serv Geneit Oncol, 26 Rue Ulm, Paris 05, France.
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- Gehrig, Andrea (author)
- Univ Wurzburg, Inst Human Genet, Dept Med Genet, Ctr Familial Breast & Ovarian Canc, Wurzburg, Germany.
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- Gerdes, Anne-Marie (author)
- Rigshosp 4062, Dept Clin Genet, Blegdamsvej 9, Copenhagen O, Denmark.
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- Giraud, Sophie (author)
- Hospices Civils Lyon, Serv Genet Mol & Clin, Lyon 04, France.
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- Godwin, Andrew K. (author)
- Univ Kansas, Med Ctr, Dept Pathol & Lab Med, 3901 Rainbow Blvd,4019 Wahl Hall East,MS 3040, Kansas City, KS USA.
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- Goldgar, David E. (author)
- Univ Utah, Sch Med, Dept Dermatol, 30 North 1900 East,SOM 4B454, Salt Lake City, UT 84132 USA.
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- Hake, Christopher R. (author)
- City Hope Natl Med Ctr, Clin Canc Genet Community Res Network, 1500 East Duarte Rd, Duarte, CA 91010 USA.
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- Hansen, Thomas V. O. (author)
- Univ Copenhagen Hosp, Ctr Genom Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
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- Healey, Sue (author)
- QIMR Berghofer Med Res Inst, Dept Genet, Herston Rd, Brisbane, Qld 4029, Australia.
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- Hodgson, Shirley (author)
- St Georges Univ London, Med Genet Unit, London, England.
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Hogervorst, Frans B. L. (author)
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- Houdayer, Claude (author)
- Inst Curie, Serv Geneit Oncol, 26 Rue Ulm, Paris 05, France.
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- Hulick, Peter J. (author)
- Univ Chicago, Pritzker Sch Med, Ctr Med Genet, NorthShore Univ Hlth Syst, 1000 Cent St,Suite 620, Evanston, IL 60201 USA.,Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, 8700 Beverly Blvd,Suite 290W, Los Angeles, CA 90048 USA.
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- Imyanitov, Evgeny N. (author)
- NN Petrov Inst Oncol, St Petersburg 197758, Russia.
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- Isaacs, Claudine (author)
- Georgetown Univ, Lombardi Comprehens Canc Ctr, 3800 Reservoir Rd NW, Washington, DC USA.
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- Izatt, Louise (author)
- Guys & St Thomas NHS Fdn Trust, Clin Genet, London, England.
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- Izquierdo, Angel (author)
- Catalan Inst Oncol, Genet Counseling Unit, Hereditary Canc Program, IDIBGI Inst Invest Biomed Girona, Av Franca S-N, Girona 1707, Spain.
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- Jacobs, Lauren (author)
- Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Res Lab, 1275 York Ave, New York, NY 10044 USA.
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- Jakubowska, Anna (author)
- Pomeranian Med Univ, Dept Genet & Pathol, Polabska 4, Szczecin, Poland.
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- Janavicius, Ramunas (author)
- Vilnius Univ Hosp Santariskiu Clin, Hematol Oncol & Transfus Med Ctr, Dept Mol & Regenerat Med, State Res Inst Ctr Innovat Med, Santariskiu St,Zygymantu St 9, Vilnius, Lithuania.,Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
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- Jaworska-Bieniek, Katarzyna (author)
- Pomeranian Med Univ, Dept Genet & Pathol, Polabska 4, Szczecin, Poland.
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- Jensen, Uffe Birk (author)
- Aarhus Univ Hosp, Dept Clin Genet, Brendstrupgaardsvej 21C, Aarhus N, Denmark.
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- John, Esther M. (author)
- Canc Prevent Inst Calif, Dept Epidemiol, 2201 Walnut Ave,Suite 300, Fremont, CA 94538 USA.
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- Vijai, Joseph (author)
- Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Res Lab, 1275 York Ave, New York, NY 10044 USA.
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- Karlan, Beth Y. (author)
- Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, 8700 Beverly Blvd,Suite 290W, Los Angeles, CA 90048 USA.
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Kast, Karin (author)
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- Khan, Sofia (author)
- Univ Helsinki, Dept Obstet & Gynecol, POB 700,Haartmaninkatu 8, Helsinki 00029, Finland.;Helsinki Univ Hosp, Biomed Helsinki, POB 700,Haartmaninkatu 8, Helsinki 00029, Finland.
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- Kwong, Ava (author)
- Hong Kong Sanat & Hosp, Canc Genet Ctr, Hong Kong Hereditary Breast Canc Family Registry, Hong Kong, Hong Kong, Peoples R China.
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- Laitman, Yael (author)
- Chaim Sheba Med Ctr, Inst Human Genet, Susanne Levy Gertner Oncogenet Unit, IL-52621 Tel Hashomer, Israel. Inst Curie, Inserm U900, Genet Epidemiol Canc team, Mines ParisTech,26 Rue Ulm, F-75248 Paris 05, France.
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Lester, Jenny (author)
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Lesueur, Fabienne (author)
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- Liljegren, Annelie (author)
- Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden.
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- Lubinski, Jan (author)
- Pomeranian Med Univ, Dept Genet & Pathol, Polabska 4, Szczecin, Poland.
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- Mai, Phuong L. (author)
- NCI, DCEG, Clin Genet Branch, NIH, 9609 Med Ctr Dr,Room 6E-454, Bethesda, MD 20892 USA.
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- Manoukian, Siranoush (author)
- Ist Nazl Tumori, Fdn IRCCS Ist Ricovero Cura & Caratter Sci, Dept Prevent & Predict Med, Unit Med Genet, Via Giacomo Venezian 1, I-20133 Milan, Italy.
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- Mazoyer, Sylvie (author)
- Ctr Leon Berard, Batiment Cheney D,28 Rue Laennec, Lyon, France.
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- Meindl, Alfons (author)
- Tech Univ Munich, Klinikum Rechts Isar, Div Tumor Genet, Dept Obstet & Gynaecol, Munich, Germany.
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- Mensenkamp, Arjen R. (author)
- Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, POB 9101, NL-6500 HB Nijmegen, Netherlands.
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- Montagna, Marco (author)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA.
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- Nathanson, Katherine L. (author)
- Univ Penn, Dept Med, Abramson Canc Ctr, Perelman Sch Med, 3400 Civic Ctr Blvd, Philadelphia, PA 19104 USA.
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- Neuhausen, Susan L. (author)
- City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA.
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- Nevanlinna, Heli (author)
- Univ Helsinki, Dept Obstet & Gynecol, POB 700,Haartmaninkatu 8, Helsinki 00029, Finland.;Helsinki Univ Hosp, Biomed Helsinki, POB 700,Haartmaninkatu 8, Helsinki 00029, Finland.
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- Niederacher, Dieter (author)
- Univ Dusseldorf, Univ Hosp Dusseldorf, Dept Obstet & Gynaecol, Dusseldorf, Germany.
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- Olah, Edith (author)
- Natl Inst Oncol, Dept Mol Genet, Budapest, Hungary.
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- Olopade, Olufunmilayo I. (author)
- Univ Chicago Med, 5841 South Maryland Ave,MC 2115, Chicago, IL 60637 USA.
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- Ong, Kai-ren (author)
- Birmingham Womens Hosp Healthcare NHS Trust, West Midlands Reg Genet Serv, Birmingham, W Midlands, England.
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- Osorio, Ana (author)
- Spanish Natl Canc Ctr CNIO, Human Genet Grp, Madrid, Spain.
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- Park, Sue Kyung (author)
- Seoul Natl Univ, Grad Sch, Dept Biomed Sci, Dept Prevent Med,Coll Med, 103 Daehak Ro, Seoul 110799, South Korea.;Seoul Natl Univ, Canc Res Inst, 103 Daehak Ro, Seoul 110799, South Korea.
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- Paulsson-Karlsson, Ylva (author)
- Uppsala universitet,Medicinsk genetik och genomik
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- Pedersen, Inge Sokilde (author)
- Aalborg Univ Hosp, Sect Mol Diagnost, Dept Biochem, Reberbansgade 15, Aalborg, Denmark.
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- Peissel, Bernard (author)
- Ist Nazl Tumori, Fdn IRCCS Ist Ricovero Cura & Caratter Sci, Dept Prevent & Predict Med, Unit Med Genet, Via Giacomo Venezian 1, I-20133 Milan, Italy.
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- Peterlongo, Paolo (author)
- Inst Mol Oncol, IFOM, FIRC Italian Fdn Canc Res, IFOM-IEO Campus,Via Adamello 16, I-20139 Milan, Italy.,City Hope Natl Med Ctr, Clin Canc Genet, 1500 East Duarte Rd, Duarte, CA 91010 USA.,Univ Cambridge, Dept Oncol, Cambridge, England.
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- Pfeiler, Georg (author)
- Med Univ Vienna, Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
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Phelan, Catherine M. (author)
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- Piedmonte, Marion (author)
- Roswell Pk Canc Inst, NRG Oncol, Stat & Data Management Ctr, Elm St & Carlton St, Buffalo, NY 14263 USA.
-
- Poppe, Bruce (author)
- Univ Ghent, Ctr Med Genet, De Pintelaan 185, B-9000 Ghent, Belgium.
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- Angel Pujana, Miquel (author)
- Catalan Inst Oncol, IDIBELL Bellvitge Biomed Res Inst, Translat Res Lab, Barcelona, Spain.
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- Radice, Paolo (author)
- Ist Nazl Tumori, Unit Mol Bases Genet Risk & Genet Testing, Dept Prevent & Predicted Med, Fdn IRCCS Ist Ricovero Cura Caratter Sci, Amaedeolab,Via GA Amadeo 42, I-20133 Milan, Italy.
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- Rennert, Gad (author)
- Clalit Natl Israeli Canc Control Ctr, 7 Michal St, IL-34362 Haifa, Israel.;Carmel Hosp, Dept Community Med & Epidemiol, 7 Michal St, IL-34362 Haifa, Israel.;B Rappaport Fac Med, 7 Michal St, IL-34362 Haifa, Israel.
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- Rodriguez, Gustavo C. (author)
- Univ Chicago, NorthShore Univ HealthSyst, Div Gynecol Oncol, 2650 Ridge Ave Suite 1507 Walgreens, Evanston, IL 60201 USA.
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- Rookus, Matti A. (author)
- Netherlands Canc Inst, Dept Epidemiol, POB 90203, NL-1000 BE Amsterdam, Netherlands.
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- Ross, Eric A. (author)
- Fox Chase Canc Ctr, Biostat & Bioinformat Facil, 333 Coltman Ave, Philadelphia, PA 19111 USA.
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- Schmutzler, Rita Katharina (author)
- Univ Hosp Cologne, Fac Med, Ctr Hereditary Breast & Ovarian Canc, Cologne, Germany.
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- Simard, Jacques (author)
- CHU, Quebec Res Ctr, Genom Ctr, 2705 Laurier Blvd, Quebec City, PQ, Canada.;Univ Laval, 2705 Laurier Blvd, Quebec City, PQ, Canada.
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Singer, Christian F. (author)
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Slavin, Thomas P. (author)
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- Soucy, Penny (author)
- CHU, Quebec Res Ctr, Genom Ctr, 2705 Laurier Blvd, Quebec City, PQ, Canada.;Univ Laval, 2705 Laurier Blvd, Quebec City, PQ, Canada.
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- Southey, Melissa (author)
- Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Parkville, Vic, Australia.
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- Steinemann, Doris (author)
- Hannover Med Sch, Inst Cell & Mol Pathol, Hannover, Germany.
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- Stoppa-Lyonnet, Dominique (author)
- Inst Curie, Serv Geneit Oncol, 26 Rue Ulm, Paris 05, France.
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- Sukiennicki, Grzegorz (author)
- Pomeranian Med Univ, Dept Genet & Pathol, Polabska 4, Szczecin, Poland.
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- Sutter, Christian (author)
- Univ Heidelberg Hosp, Dept Human Genet, Inst Human Genet, Heidelberg, Germany.
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- Szabo, Csilla I. (author)
- NHGRI, NIH, Bldg 50,Room 5312,50 South Dr,MSC 004, Bethesda, MD 20892 USA.
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- Tea, Muy-Kheng (author)
- Med Univ Vienna, Dept OB GYN, A-1090 Vienna, Austria.;Waehringer Guertel 18-20, A-1090 Vienna, Austria.
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- Teixeira, Manuel R. (author)
- Portuguese Oncol Inst, Dept Genet, Rua Dr Antonio Bernardino de Almeida, P-4200072 Oporto, Portugal.
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- Teo, Soo-Hwang (author)
- Sime Darby Med Ctr, Canc Res Initiat Fdn, 1 Jalan SS12-1A, Subang Jaya 47500, Malaysia.
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- Terry, Mary Beth (author)
- Columbia Univ, Dept Epidemiol, New York, NY USA.
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- Thomassen, Mads (author)
- Odense Univ Hosp, Dept Clin Genet, Sonder Blvd 29, Odense C, Denmark.
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- Tibiletti, Maria Grazia (author)
- Osped Circolo Univ Insubria, UO Anat Patol, Via O Rossi 9, I-21100 Varese, Italy.
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- Tihomirova, Laima (author)
- Latvian Biomed Res & Study Ctr, Ratsupites Str 1, Riga, Latvia.
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- Tognazzo, Silvia (author)
- Veneto Inst Oncol IOV IRCCS, Immunol & Mol Oncol Unit, Via Gattamelata 64, Padua, Italy.
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- van Rensburg, Elizabeth J. (author)
- Univ Pretoria, Dept Genet, Canc Genet Lab, Private Bag X323, ZA-0007 Arcadia, South Africa.
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- Varesco, Liliana (author)
- AOU San Martino IST Ist Nazl Ric Cancro, IRCCS, Dept Epidemiol Prevent & Special Funct, Unit Hereditary Canc, Largo Rosanna Benzi 10, I-16132 Genoa, Italy.
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- Varon-Mateeva, Raymonda (author)
- Charite, Inst Human Genet, Campus Virchov Klinikum, Berlin, Germany.
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- Vratimos, Athanassios (author)
- Natl Ctr Sci Res Demokritos, INRASTES Inst Nucl & Radiol Sci & Technol, Mol Diagnost Lab, Patriarchou Gregoriou & Neapoleos Str, Athens, Greece.
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- Weitzel, Jeffrey N. (author)
- City Hope Natl Med Ctr, Clin Canc Genet, 1500 East Duarte Rd, Duarte, CA 91010 USA.
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- McGuffog, Lesley (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.
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- Kirk, Judy (author)
- Westmead Hosp, Familial Canc Serv, Hawkesbury Rd,POB 533, Wentworthville, NSW 2145, Australia.
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- Toland, Amanda Ewart (author)
- Ohio State Univ, Dept Internal Med, Div Human Canc Genet, 998 Biomed Res Tower, Columbus, OH 43210 USA.;Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA.
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- Hamann, Ute (author)
- German Canc Res Ctr, Mol Genet Breast Canc, Neuenheimer Feld 580, D-69120 Heidelberg, Germany.
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- Lindor, Noralane (author)
- Mayo Clin, Dept Hlth Sci Res, 13400 E Scottsdale Blvd, Scottsdale, AZ USA.
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Ramus, Susan J. (author)
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- Greene, Mark H. (author)
- NCI, DCEG, Clin Genet Branch, NIH, 9609 Med Ctr Dr,Room 6E-454, Bethesda, MD 20892 USA.
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- Couch, Fergus J. (author)
- Mayo Clin, Dept Lab Med & Pathol, 200 First St SW, Rochester, MN USA.;Mayo Clin, Hlth Sci Res, 200 First St SW, Rochester, MN USA.
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- Offit, Kenneth (author)
- Mem Sloan Kettering Canc Ctr, Clin Genet Res Lab, Dept Med Canc Biol & Genet, 1275 York Ave, New York, NY 10044 USA.
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Pharoah, Paul D. P. (author)
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- Chenevix-Trench, Georgia (author)
- QIMR Berghofer Med Res Inst, Dept Genet, Herston Rd, Brisbane, Qld 4029, Australia.
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- Antoniou, Antonis C. (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England.
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Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, 1515 Pressler St,CBP 5, Houston, TX USA.;Univ Texas MD Anderson Canc Ctr, Clin Canc Genet Program, 1515 Pressler St,CBP 5, Houston, TX USA. (creator_code:org_t)
- 2016-07-27
- 2016
- English.
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:7
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Abstract
Subject headings
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- Population-based genome wide association studies have identified a locus at 9p22.2 associated with ovarian cancer risk, which also modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We conducted fine-scale mapping at 9p22.2 to identify potential causal variants in BRCA1 and BRCA2 mutation carriers. Genotype data were available for 15,252 (2,462 ovarian cancer cases) BRCA1 and 8,211 (631 ovarian cancer cases) BRCA2 mutation carriers. Following genotype imputation, ovarian cancer associations were assessed for 4,873 and 5,020 SNPs in BRCA1 and BRCA2 mutation carriers respectively, within a retrospective cohort analytical framework. In BRCA1 mutation carriers one set of eight correlated candidate causal variants for ovarian cancer risk modification was identified (top SNP rs10124837, HR: 0.73, 95% CI: 0.68 to 0.79, p-value 2x 10-16). These variants were located up to 20 kb upstream of BNC2. In BRCA2 mutation carriers one region, up to 45 kb upstream of BNC2, and containing 100 correlated SNPs was identified as candidate causal (top SNP rs62543585, HR: 0.69, 95% CI: 0.59 to 0.80, p-value 1.0 x 10-6). The candidate causal in BRCA1 mutation carriers did not include the strongest associated variant at this locus in the general population. In sum, we identified a set of candidate causal variants in a region that encompasses the BNC2 transcription start site. The ovarian cancer association at 9p22.2 may be mediated by different variants in BRCA1 mutation carriers and in the general population. Thus, potentially different mechanisms may underlie ovarian cancer risk for mutation carriers and the general population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- ref (subject category)
- art (subject category)
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Vigorito, Elena
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Kuchenbaecker, K ...
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Beesley, Jonatha ...
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Adlard, Julian
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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PLOS ONE
- By the university
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Umeå University
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Karolinska Institutet
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Uppsala University