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Three new pancreati...
Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21
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Zhang, Mingfeng (author)
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Wang, Zhaoming (author)
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Obazee, Ofure (author)
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show more...
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Jia, Jinping (author)
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Childs, Erica J. (author)
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Hoskins, Jason (author)
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Figlioli, Gisella (author)
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Mocci, Evelina (author)
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Collins, Irene (author)
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Chung, Charles C. (author)
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Hautman, Christopher (author)
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Arslan, Alan A. (author)
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Beane-Freeman, Laura (author)
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Bracci, Paige M. (author)
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Buring, Julie (author)
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Duell, Eric J. (author)
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Gallinger, Steven (author)
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Giles, Graham G. (author)
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Goodman, Gary E. (author)
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Goodman, Phyllis J. (author)
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Kamineni, Aruna (author)
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Kolonel, Laurence N. (author)
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Kulke, Matthew H. (author)
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Malats, Nuria (author)
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Olson, Sara H. (author)
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Sesso, Howard D. (author)
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Visvanathan, Kala (author)
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White, Emily (author)
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Zheng, Wei (author)
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Abnet, Christian C. (author)
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Albanes, Demetrius (author)
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Andreotti, Gabriella (author)
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Brais, Lauren (author)
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Bueno-de-Mesquita, H. Bas (author)
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Basso, Daniela (author)
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Berndt, Sonja I. (author)
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Boutron-Ruault, Marie-Christine (author)
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Bijlsma, Maarten F. (author)
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Brenner, Hermann (author)
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Burdette, Laurie (author)
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Campa, Daniele (author)
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Caporaso, Neil E. (author)
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Capurso, Gabriele (author)
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Cavestro, Giulia Martina (author)
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Cotterchio, Michelle (author)
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Costello, Eithne (author)
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Elena, Joanne (author)
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Boggi, Ugo (author)
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Gaziano, J. Michael (author)
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Gazouli, Maria (author)
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Giovannucci, Edward L. (author)
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Goggins, Michael (author)
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Gross, Myron (author)
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Haiman, Christopher A. (author)
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Hassan, Manal (author)
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Helzlsouer, Kathy J. (author)
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Hu, Nan (author)
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Hunter, David J. (author)
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Iskierka-Jazdzewska, Elzbieta (author)
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Jenab, Mazda (author)
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Kaaks, Rudolf (author)
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Key, Timothy J. (author)
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Khaw, Kay-Tee (author)
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Klein, Eric A. (author)
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Kogevinas, Manolis (author)
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Krogh, Vittorio (author)
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Kupcinskas, Juozas (author)
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Kurtz, Robert C. (author)
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Landi, Maria T. (author)
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Landi, Stefano (author)
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Le Marchand, Loic (author)
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Mambrini, Andrea (author)
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Mannisto, Satu (author)
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Milne, Roger L. (author)
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Neale, Rachel E. (author)
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Oberg, Ann L. (author)
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Panico, Salvatore (author)
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Patel, Alpa V. (author)
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Peeters, Petra H. M. (author)
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Peters, Ulrike (author)
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Pezzilli, Raffaele (author)
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Porta, Miquel (author)
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Purdue, Mark (author)
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Ramon Quiros, J. (author)
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Riboli, Elio (author)
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Rothman, Nathaniel (author)
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Scarpa, Aldo (author)
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Scelo, Ghislaine (author)
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Shu, Xiao-Ou (author)
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Silverman, Debra T. (author)
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Soucek, Pavel (author)
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Strobel, Oliver (author)
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- Sund, Malin (author)
- Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap
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Malecka-Panas, Ewa (author)
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Taylor, Philip R. (author)
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Tavano, Francesca (author)
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Travis, Ruth C. (author)
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Thornquist, Mark (author)
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Tjonneland, Anne (author)
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Tobias, Geoffrey S. (author)
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Trichopoulos, Dimitrios (author)
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Vashist, Yogesh (author)
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Vodicka, Pavel (author)
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Wactawski-Wende, Jean (author)
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Wentzensen, Nicolas (author)
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Yu, Herbert (author)
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Yu, Kai (author)
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Zeleniuch-Jacquotte, Anne (author)
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Kooperberg, Charles (author)
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Risch, Harvey A. (author)
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Jacobs, Eric J. (author)
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Li, Donghui (author)
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Fuchs, Charles (author)
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Hoover, Robert (author)
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Hartge, Patricia (author)
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Chanock, Stephen J. (author)
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Petersen, Gloria M. (author)
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Stolzenberg-Solomon, Rachael S. (author)
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Wolpin, Brian M. (author)
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Kraft, Peter (author)
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Klein, Alison P. (author)
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Canzian, Federico (author)
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Amundadottir, Laufey T. (author)
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(creator_code:org_t)
- 2016-08-01
- 2016
- English.
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In: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 7:41, s. 66328-66343
- Related links:
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https://umu.diva-por... (primary) (Raw object)
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http://www.oncotarge...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Genome-wide association studies (GWAS) have identified common pancreatic cancer susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify new susceptibility variants, we performed imputation based on 1000 Genomes (1000G) Project data and association analysis using 5,107 case and 8,845 control subjects from 27 cohort and case-control studies that participated in the PanScan I-III GWAS. This analysis, in combination with a two-staged replication in an additional 6,076 case and 7,555 control subjects from the PANcreatic Disease ReseArch (PANDoRA) and Pancreatic Cancer Case-Control (PanC4) Consortia uncovered 3 new pancreatic cancer risk signals marked by single nucleotide polymorphisms (SNPs) rs2816938 at chromosome 1q32.1 (per allele odds ratio (OR) = 1.20, P = 4.88x10(-15)), rs10094872 at 8q24.21 (OR = 1.15, P = 3.22x10(-9)) and rs35226131 at 5p15.33 (OR = 0.71, P = 1.70x10(-8)). These SNPs represent independent risk variants at previously identified pancreatic cancer risk loci on chr1q32.1 (NR5A2), chr8q24.21 (MYC) and chr5p15.33 (CLPTM1L-TERT) as per analyses conditioned on previously reported susceptibility variants. We assessed expression of candidate genes at the three risk loci in histologically normal (n = 10) and tumor (n = 8) derived pancreatic tissue samples and observed a marked reduction of NR5A2 expression (chr1q32.1) in the tumors (fold change -7.6, P = 5.7x10(-8)). This finding was validated in a second set of paired (n = 20) histologically normal and tumor derived pancreatic tissue samples (average fold change for three NR5A2 isoforms -31.3 to -95.7, P = 7.5x10(-4)-2.0x10(-3)). Our study has identified new susceptibility variants independently conferring pancreatic cancer risk that merit functional follow-up to identify target genes and explain the underlying biology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Oncotarget
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To the university's database
- By the author/editor
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Zhang, Mingfeng
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Wang, Zhaoming
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Obazee, Ofure
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Jia, Jinping
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Childs, Erica J.
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Hoskins, Jason
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show more...
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Figlioli, Gisell ...
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Mocci, Evelina
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Collins, Irene
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Chung, Charles C ...
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Hautman, Christo ...
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Arslan, Alan A.
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Beane-Freeman, L ...
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Bracci, Paige M.
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Buring, Julie
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Duell, Eric J.
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Gallinger, Steve ...
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Giles, Graham G.
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Goodman, Gary E.
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Goodman, Phyllis ...
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Kamineni, Aruna
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Kolonel, Laurenc ...
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Kulke, Matthew H ...
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Malats, Nuria
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Olson, Sara H.
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Sesso, Howard D.
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Visvanathan, Kal ...
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White, Emily
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Zheng, Wei
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Abnet, Christian ...
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Albanes, Demetri ...
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Andreotti, Gabri ...
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Brais, Lauren
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Bueno-de-Mesquit ...
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Basso, Daniela
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Berndt, Sonja I.
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Boutron-Ruault, ...
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Bijlsma, Maarten ...
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Brenner, Hermann
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Burdette, Laurie
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Campa, Daniele
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Caporaso, Neil E ...
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Capurso, Gabriel ...
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Cavestro, Giulia ...
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Cotterchio, Mich ...
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Costello, Eithne
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Elena, Joanne
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Boggi, Ugo
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Gaziano, J. Mich ...
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Gazouli, Maria
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Giovannucci, Edw ...
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Goggins, Michael
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Gross, Myron
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Haiman, Christop ...
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Hassan, Manal
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Helzlsouer, Kath ...
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Hu, Nan
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Hunter, David J.
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Iskierka-Jazdzew ...
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Jenab, Mazda
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Kaaks, Rudolf
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Key, Timothy J.
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Khaw, Kay-Tee
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Klein, Eric A.
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Kogevinas, Manol ...
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Krogh, Vittorio
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Kupcinskas, Juoz ...
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Kurtz, Robert C.
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Landi, Maria T.
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Landi, Stefano
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Le Marchand, Loi ...
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Mambrini, Andrea
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Mannisto, Satu
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Milne, Roger L.
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Neale, Rachel E.
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Oberg, Ann L.
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Panico, Salvator ...
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Patel, Alpa V.
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Peeters, Petra H ...
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Peters, Ulrike
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Pezzilli, Raffae ...
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Porta, Miquel
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Purdue, Mark
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Ramon Quiros, J.
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Riboli, Elio
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Rothman, Nathani ...
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Scarpa, Aldo
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Scelo, Ghislaine
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Shu, Xiao-Ou
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Silverman, Debra ...
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Soucek, Pavel
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Strobel, Oliver
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Sund, Malin
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Malecka-Panas, E ...
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Taylor, Philip R ...
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Tavano, Francesc ...
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Travis, Ruth C.
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Thornquist, Mark
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Tjonneland, Anne
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Tobias, Geoffrey ...
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Trichopoulos, Di ...
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Vashist, Yogesh
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Vodicka, Pavel
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Wactawski-Wende, ...
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Wentzensen, Nico ...
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Yu, Herbert
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Yu, Kai
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Zeleniuch-Jacquo ...
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Kooperberg, Char ...
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Risch, Harvey A.
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Jacobs, Eric J.
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Li, Donghui
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Fuchs, Charles
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Hoover, Robert
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Hartge, Patricia
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Chanock, Stephen ...
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Petersen, Gloria ...
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Stolzenberg-Solo ...
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Wolpin, Brian M.
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Kraft, Peter
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Klein, Alison P.
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Canzian, Federic ...
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Amundadottir, La ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Oncotarget
- By the university
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Umeå University