SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:DiVA.org:umu-128563"
 

Search: id:"swepub:oai:DiVA.org:umu-128563" > Preoperative anaemi...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Mörner, Malin E MKarolinska Institutet (author)

Preoperative anaemia and perioperative red blood cell transfusion as prognostic factors for recurrence and mortality in colorectal cancer-a Swedish cohort study

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2016-10-21
  • Springer Science and Business Media LLC,2017
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-128563
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-128563URI
  • https://doi.org/10.1007/s00384-016-2678-3DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135257378URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • PURPOSE: The hypothesis in this study was that anaemia prior to surgery and perioperative red blood cell transfusion increases the risk for recurrence and overall mortality in patients with stages I-III colorectal cancer after abdominal resection with curative intent.METHODS: This is a Swedish single centre retrospective cohort study. Data on 496 consecutive radical abdominal resections stages I-III colorectal cancer performed at the Karolinska University Hospital 2007-2010 were extracted from the Swedish Colorectal Cancer Registry. Data were linked to local laboratory and transfusion databases to identify preoperative anaemia and perioperative transfusion. Disease recurrence was validated by scrutiny of patient records. A total of 496 stages I-III colorectal cancer patients were included in the analysis. Multivariate Cox regression analysis adjusted for tumour and patient characteristics were performed to assess risk for recurrence and overall mortality.RESULTS: Anaemia prior to surgery was associated with increased risk for overall mortality (HR 2.1, 95% CI 1.4-3.2). There was no association between anaemia and risk for recurrence (HR 1.6, 95% CI 0.97-2.6). Transfusion was not associated with increased risk of recurrence (HR 0.7, 95% CI 0.4-1.3) or overall mortality (HR 1.04, 95% CI 0.7-1.6).CONCLUSIONS: Anaemia prior to colorectal cancer surgery was associated with increased risk for overall mortality while a no increased risk was seen for recurrence. Previous findings indicating an association between blood transfusion and increased risk for recurrence could not be confirmed.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Edgren, GustafKarolinska Institutet (author)
  • Martling, AnnaKarolinska Institutet (author)
  • Gunnarsson, UlfUmeå universitet,Kirurgi(Swepub:umu)ulgu0014 (author)
  • Egenvall, Monika (author)
  • Karolinska InstitutetKirurgi (creator_code:org_t)

Related titles

  • In:International Journal of Colorectal Disease: Springer Science and Business Media LLC32:2, s. 223-2320179-19581432-1262

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Find more in SwePub

By the author/editor
Mörner, Malin E ...
Edgren, Gustaf
Martling, Anna
Gunnarsson, Ulf
Egenvall, Monika
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Surgery
Articles in the publication
International Jo ...
By the university
Umeå University
Karolinska Institutet

Search outside SwePub

Wikipedia about the author:
Malin_E_M_Mörner
Mörner, Malin E M
en

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view