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  • Yu, Fang-FangInstitute of Endemic Diseases, School of Public Health of Health Science Center, Xi’an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, China (author)

Identified molecular mechanism of interaction between environmental risk factors and differential expression genes in cartilage of Kashin-Beck disease

  • Article/chapterEnglish2016

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  • Wolters Kluwer,2016
  • electronicrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:umu-129536
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-129536URI
  • https://doi.org/10.1097/MD.0000000000005669DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype

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  • As environmental risk factors (ERFs) play an important role in the pathogenesis of Kashin-Beck disease (KBD), it is important to identify the interaction between ERFs and differentially expression genes (DEGs) in KBD. The environmental response genes (ERGs) were analyzed in cartilage of KBD in comparison to normal controls.We searched 5 English and 3 Chinese databases from inception to September 2015, to identify case-control studies that examined ERFs for KBD using integrative meta-analysis and systematic review. Total RNA was isolated from articular cartilage of KBD patients and healthy controls. Human whole genome microarray chip (Agilent) was used to analyze the amplified, labeled, and hybridized total RNA, and the validated microarray data were partially verified using real-time quantitative polymerase chain reaction (qRT-PCR). The ERGs were derived from the Comparative Toxicogenomics Database. The identified ERGs were subjected to KEGG pathway enrichment, biological process (BP), and interaction network analyses using the Database for Annotation, Visualization and Integrated Discovery (DAVID) v6.7, and STRING.The trace elements (selenium and iodine), vitamin E, and polluted grains (T-2 toxin/HT-2 toxin, deoxynivalenol, and nivalenol) were identified as the ERFs for KBD using meta-analysis and review. We identified 21 upregulated ERGs and 7 downregulated ERGs in cartilage with KBD compared with healthy controls, which involved in apoptosis, metabolism, and growth and development. KEGG pathway enrichment analysis found that 2 significant pathways were involved with PI3K-Akt signaling pathway and P53 signaling pathway, and gene ontology function analysis found 3 BPs involved with apoptosis, death, and cell death in KBD cartilage.According to previous results and our own research, we suggest that the trace element selenium and vitamin E induce PI3K-Akt signaling pathway and the mycotoxins (T-2 toxin/HT-2 toxin and DON) induce P53 signaling pathway, contributing to the development of KBD, and chondrocyte apoptosis and cell death.

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  • Zhang, Yan-XiangDepartment of Orthopedics, Baoji People’s Hospital, Baoji, China (author)
  • Zhang, Lian-HeInstitute of Endemic Diseases, School of Public Health of Health Science Center, Xi’an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, China (author)
  • Li, Wen-RongInstitute of Endemic Diseases, School of Public Health of Health Science Center, Xi’an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, China (author)
  • Guo, XiongInstitute of Endemic Diseases, School of Public Health of Health Science Center, Xi’an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, China (author)
  • Lammi, Mikko,1961-Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Institute of Endemic Diseases, School of Public Health of Health Science Center, Xi’an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, China,Chondrogenic and Osteogenic Differentiation Group(Swepub:umu)mila0077 (author)
  • Institute of Endemic Diseases, School of Public Health of Health Science Center, Xi’an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi’an, ChinaDepartment of Orthopedics, Baoji People’s Hospital, Baoji, China (creator_code:org_t)

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  • In:Medicine: Wolters Kluwer95:520025-79741536-5964

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By the author/editor
Yu, Fang-Fang
Zhang, Yan-Xiang
Zhang, Lian-He
Li, Wen-Rong
Guo, Xiong
Lammi, Mikko, 19 ...
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MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
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and Rheumatology and ...
MEDICAL AND HEALTH SCIENCES
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Medicine
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Umeå University

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