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  • Danneman, DanielaKarolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden. (författare)

Accuracy of prostate biopsies for predicting Gleason score in radical prostatectomy specimens : nationwide trends 2000-2012

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2016-03-24
  • Wiley,2017
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-130217
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-130217URI
  • https://doi.org/10.1111/bju.13458DOI
  • https://lup.lub.lu.se/record/8821571URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:134811226URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-313511URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objectives To investigate how well the Gleason score in diagnostic needle biopsies predicted the Gleason score in a subsequent radical prostatectomy (RP) specimen before and after the 2005 International Society of Urological Pathology (ISUP) revision of Gleason grading, and if the recently proposed ISUP grades 1-5 (corresponding to Gleason scores 6, 3 + 4, 4 + 3, 8 and 9-10) better predict the RP grade. Patients and Methods All prostate cancers diagnosed in Sweden are reported to the National Prostate Cancer Register (NPCR). We analysed the Gleason scores and ISUP grades from the diagnostic biopsies and the RP specimens in 15 598 men in the NPCR who: were diagnosed between 2000 and 2012 with clinical stage T1-2 M0/X prostate cancer on needle biopsy; were aged <= 70 years; had serum PSA concentration of < 20 ng/mL; and underwent a RP < 6 months after diagnosis as their primary treatment. Results Prediction of RP Gleason score increased from 55 to 68% between 2000 and 2012. Most of the increase occurred before 2005 (nine percentage points; P < 0.001); however, when adjusting for Gleason score and year of diagnosis in a multivariable analysis, the prediction of RP Gleason score decreased over time (odds ratio [OR] 0.98; P < 0.002). A change in the ISUP grades would have led to a decreasing agreement between biopsy and RP grades over time, from 68% in 2000 to 57% in 2012, with an OR of 0.95 in multivariable analysis (P < 0.001). Conclusion Agreement between biopsy and RP Gleason score improved from 2000 to 2012, with most of the improvement occurring before the 2005 ISUP grading revision. Had ISUP grades been used instead of Gleason score, the agreement between biopsy and RP grade would have decreased, probably because of its separation of Gleason score 7 into ISUP grades 2 and 3 (Gleason score 3 + 4 vs 4 + 3).

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Drevin, LindaUniv Uppsala Hosp, Reg Canc Ctr, Uppsala, Sweden. (författare)
  • Delahunt, BrettUniv Otago, Wellington Sch Med & Hlth Sci, Wellington, New Zealand. (författare)
  • Samaratunga, HemamaliAquesta Pathol, Brisbane, Qld, Australia.;Univ Queensland, Sch Med, Brisbane, Qld, Australia. (författare)
  • Robinson, DavidRyhov Cty Hosp, Dept Urol, Jonkoping, Sweden. (författare)
  • Bratt, OlaLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,Cambridge Univ Hosp, Dept Urol, Cambridge, England.;Lund Univ, Dept Translat Med, Lund, Sweden.(Swepub:lu)urok-obr (författare)
  • Loeb, StacyNYU, Dept Urol & Populat Hlth, New York, NY USA.;Manhattan Vet Affairs Med Ctr, New York, NY USA. (författare)
  • Stattin, PärUppsala universitet,Umeå universitet,Urologi och andrologi,Urologkirurgi,Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden.(Swepub:uu)parst892 (författare)
  • Egevad, LarsKarolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Pathol, Stockholm, Sweden. (författare)
  • Karolinska InstitutetKarolinska Inst, Dept Oncol Pathol, Stockholm, Sweden. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BJU International: Wiley119:1, s. 50-561464-40961464-410X

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