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Predicting glycated...
Predicting glycated hemoglobin levels in the non-diabetic general population : development and validation of the DIRECT-DETECT prediction model - a DIRECT study
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- Rauh, Simone P (författare)
- Vrije Universiteit Amsterdam
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- Heymans, Martijn W (författare)
- Vrije Universiteit Amsterdam
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- Koopman, Anitra D M (författare)
- Vrije Universiteit Amsterdam
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- Nijpels, Giel (författare)
- Vrije Universiteit Amsterdam
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- Stehouwer, Coen D (författare)
- Maastricht University
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- Thorand, Barbara (författare)
- German Center for Diabetes Research,Helmholtz Zentrum München
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- Rathmann, Wolfgang (författare)
- Heinrich Heine University Düsseldorf
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- Meisinger, Christa (författare)
- Helmholtz Zentrum München
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- Peters, Annette (författare)
- German Center for Diabetes Research,Helmholtz Zentrum München
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- de Las Heras Gala, Tonia (författare)
- Helmholtz Zentrum München
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- Glümer, Charlotte (författare)
- Glostrup Hospital
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- Pedersen, Oluf (författare)
- University of Copenhagen
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- Cederberg, Henna (författare)
- University of Eastern Finland
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- Kuusisto, Johanna (författare)
- University of Eastern Finland
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- Laakso, Markku (författare)
- University of Eastern Finland
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- Pearson, Ewan R (författare)
- University of Dundee
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- Franks, Paul W (författare)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Medicin,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University; Harvard Chan School of Public Health, Boston, Massachusetts, United States of America,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Rutters, Femke (författare)
- Vrije Universiteit Amsterdam
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- Dekker, Jacqueline M (författare)
- Vrije Universiteit Amsterdam
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(creator_code:org_t)
- 2017-02-10
- 2017
- Engelska.
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 12:2
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://journals.plo...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
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- AIMS/HYPOTHESIS: To develop a prediction model that can predict HbA1c levels after six years in the non-diabetic general population, including previously used readily available predictors.METHODS: Data from 5,762 initially non-diabetic subjects from three population-based cohorts (Hoorn Study, Inter99, KORA S4/F4) were combined to predict HbA1c levels at six year follow-up. Using backward selection, age, BMI, waist circumference, use of anti-hypertensive medication, current smoking and parental history of diabetes remained in sex-specific linear regression models. To minimize overfitting of coefficients, we performed internal validation using bootstrapping techniques. Explained variance, discrimination and calibration were assessed using R2, classification tables (comparing highest/lowest 50% HbA1c levels) and calibration graphs. The model was externally validated in 2,765 non-diabetic subjects of the population-based cohort METSIM.RESULTS: At baseline, mean HbA1c level was 5.6% (38 mmol/mol). After a mean follow-up of six years, mean HbA1c level was 5.7% (39 mmol/mol). Calibration graphs showed that predicted HbA1c levels were somewhat underestimated in the Inter99 cohort and overestimated in the Hoorn and KORA cohorts, indicating that the model's intercept should be adjusted for each cohort to improve predictions. Sensitivity and specificity (95% CI) were 55.7% (53.9, 57.5) and 56.9% (55.1, 58.7) respectively, for women, and 54.6% (52.7, 56.5) and 54.3% (52.4, 56.2) for men. External validation showed similar performance in the METSIM cohort.CONCLUSIONS/INTERPRETATION: In the non-diabetic population, our DIRECT-DETECT prediction model, including readily available predictors, has a relatively low explained variance and moderate discriminative performance, but can help to distinguish between future highest and lowest HbA1c levels. Absolute HbA1c values are cohort-dependent.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Rauh, Simone P
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Heymans, Martijn ...
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Koopman, Anitra ...
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Nijpels, Giel
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Stehouwer, Coen ...
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Thorand, Barbara
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Rathmann, Wolfga ...
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Meisinger, Chris ...
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Peters, Annette
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de Las Heras Gal ...
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Glümer, Charlott ...
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Pedersen, Oluf
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Cederberg, Henna
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Kuusisto, Johann ...
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Laakso, Markku
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Pearson, Ewan R
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Franks, Paul W
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Rutters, Femke
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Dekker, Jacqueli ...
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Umeå universitet
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