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Rituximab in multip...
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Salzer, JonatanUmeå universitet,Klinisk neurovetenskap
(författare)
Rituximab in multiple sclerosis : a retrospective observational study on safety and efficacy
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2016
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-132168
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-132168URI
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https://doi.org/10.1212/WNL.0000000000003331DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:135039679URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Objective: To investigate the safety and efficacy of rituximab in multiple sclerosis (MS). Methods: In this retrospective uncontrolled observational multicenter study, off-label rituximab-treated patients with MS were identified through the Swedish MS register. Outcome data were collected from the MS register and medical charts. Adverse events (AEs) grades 2-5 according to the Common Terminology Criteria for Adverse Events were recorded. Results: A total of 822 rituximab-treated patients with MS were identified: 557 relapsing-remitting MS (RRMS), 198 secondary progressive MS (SPMS), and 67 primary progressive MS (PPMS). At baseline, 26.2% had contrast-enhancing lesions (CELs). Patients were treated with 500 or 1,000 mg rituximab IV every 6-12 months, during a mean 21.8 (SD 14.3) months. During treatment, the annualized relapse rates were 0.044 (RRMS), 0.038 (SPMS), and 0.015 (PPMS), and 4.6% of patients displayed CELs. Median Expanded Disability Status Scale remained unchanged in RRMS (p = 0.42) and increased by 0.5 and 1.0 in SPMS and PPMS, respectively (p = 0.10 and 0.25). Infusion-related AEs occurred during 7.8% of infusions and most were mild. A total of 89 AEs grades >= 2 (of which 76 infections) were recorded in 72 patients. No case of progressive multifocal leukoencephalopathy was detected. Conclusions: This is the largest cohort of patients with MS treated with rituximab reported so far. The safety, clinical, and MRI findings in this heterogeneous real-world cohort treated with different doses of rituximab were similar to those reported in previous randomized controlled trials on B-cell depletion therapy in MS. Classification of evidence: This study provides Class IV evidence that for patients with MS, rituximab is safe and effective.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Svenningsson, RasmusUmeå universitet,Klinisk neurovetenskap,Department of Clinical Neuroscience, Danderyd Hospital, Karolinska Institutet, Stockholm
(författare)
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Alping, PeterKarolinska Institutet
(författare)
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Novakova, Lenka
(författare)
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Björck, Anna
(författare)
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Fink, KatharinaKarolinska Institutet
(författare)
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Islam-Jakobsson, ProtikUmeå universitet,Klinisk neurovetenskap
(författare)
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Malmeström, Clas
(författare)
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Axelsson, Markus
(författare)
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Vågberg, MattiasUmeå universitet,Klinisk neurovetenskap(Swepub:umu)maswag04
(författare)
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Sundström, PeterUmeå universitet,Klinisk neurovetenskap(Swepub:umu)pesu0002
(författare)
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Lycke, Jan
(författare)
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Piehl, FredrikKarolinska Institutet
(författare)
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Svenningsson, AndersKarolinska Institutet,Umeå universitet,Klinisk neurovetenskap,Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm(Swepub:umu)ansv0041
(författare)
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Umeå universitetKlinisk neurovetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Neurology87:20, s. 2074-20810028-38781526-632X
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Salzer, Jonatan
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Svenningsson, Ra ...
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Alping, Peter
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Novakova, Lenka
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Björck, Anna
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Fink, Katharina
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visa fler...
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Islam-Jakobsson, ...
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Malmeström, Clas
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Axelsson, Markus
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Vågberg, Mattias
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Sundström, Peter
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Lycke, Jan
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Piehl, Fredrik
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Svenningsson, An ...
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visa färre...
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Neurology
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Umeå universitet
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