Search: (WFRF:(Gunter Marc J.)) pers:(Peeters Petra H) srt2:(2017) >
Prediagnostic circu...
Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition
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- Perez-Cornago, Aurora (author)
- University of Oxford
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- Appleby, Paul N. (author)
- University of Oxford
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- Tipper, Sarah (author)
- University of Oxford
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- Key, Timothy J. (author)
- University of Oxford
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- Allen, Naomi E. (author)
- University of Oxford
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- Nieters, Alexandra (author)
- University Medical Center Freiburg
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- Vermeulen, Roel (author)
- Utrecht University
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- Roulland, Sandrine (author)
- Centre d'Immunologie Marseille Luminy
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- Casabonne, Delphine (author)
- Bellvitge Biomedical Research Institute
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- Kaaks, Rudolf (author)
- German Cancer Research Centre
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- Fortner, Renee T. (author)
- German Cancer Research Centre
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- Boeing, Heiner (author)
- German Institute of Human Nutrition
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- Trichopoulou, Antonia (author)
- National and Kapodistrian University of Athens
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- La Vecchia, Carlo (author)
- University of Milan
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Klinaki, Eleni (author)
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- Hansen, Louise (author)
- Danish Cancer Society
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- Tjonneland, Anne (author)
- Danish Cancer Society
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- Bonnet, Fabrice (author)
- Rennes University Hospital
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- Fagherazzi, Guy (author)
- University of Paris-Saclay
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- Boutron-Ruault, Marie-Christine (author)
- University of Paris-Saclay
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- Pala, Valeria (author)
- Istituto Nazionale dei Tumori
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- Masala, Giovanna (author)
- Cancer Research and Prevention Institute (ISPO)
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- Sacerdote, Carlotta (author)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Peeters, Petra H. (author)
- MRC Human Nutrition Research
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- Bueno-de-Mesquita, H. B(as) (author)
- University of Malaya
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- Weiderpass, Elisabete (author)
- Karolinska Institutet,Folkhälsan Research Center
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- Dorronsoro, Miren (author)
- CIBER Epidemiology and Public Health (CIBERESP)
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Quiros, J. Ramon (author)
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- Barricarte, Aurelio (author)
- Health Research Institute of Navarra (IDISNA)
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- Gavrila, Diana (author)
- Murcia Regional Health Council
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- Agudo, Antonio (author)
- Bellvitge Biomedical Research Institute
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- Borgquist, Signe (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Rosendahl, Ann H. (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Melin, Beatrice (author)
- Umeå University,Umeå universitet,Onkologi
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- Wareham, Nick (author)
- University of Cambridge
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- Khaw, Kay-Tee (author)
- University of Cambridge
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- Gunter, Marc (author)
- International Agency for Research on Cancer, World Health Organization
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- Riboli, Elio (author)
- Imperial College London
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- Vineis, Paolo (author)
- Imperial College London
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- Travis, Ruth C. (author)
- University of Oxford
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(creator_code:org_t)
- 2016-12-27
- 2017
- English.
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In: International Journal of Cancer. - : WILEY-BLACKWELL. - 0020-7136 .- 1097-0215. ; 140:5, s. 1111-1118
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Abstract
Subject headings
Close
- Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third = 0.77 [95% CI = 0.57-1.03], p(trend) = 0.06). There was no statistical evidence of heterogeneity in this association with IGF-I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (pheterogeneity for all >= 0.05). There were no associations between IGF-I concentration and risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF-I concentrations and risk of lymphoma. Further What's new? Insulin-like growth factor I does not appear to influence lymphoma risk, according to new results. IGF-I can promote some cancers, but there hasn't been a prospective epidemiological study examining the link between IGF-I concentration and lymphoma risk. To uncover a link, these authors arranged a NESTED case-control study with participants from the European Prospective Investigation into Cancer and Nutrition (EPIC). They tested for IGF-I in pre-diagnosis samples and found no association between the factor and overall lymphoma risk, nor with any subtype, although the number of cases was small for each subtype, and further studies are necessary.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- prospective
- lymphoma
- non-Hodgkin lymphoma
- plasma
- IGF-I
- EPIC cohort
- nested case-control
- EPIC cohort
- IGF-I
- Lymphoma
- Nested case-control
- Non-Hodgkin lymphoma
- Plasma
- Prospective
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Perez-Cornago, A ...
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Appleby, Paul N.
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Tipper, Sarah
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Key, Timothy J.
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Allen, Naomi E.
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Nieters, Alexand ...
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show more...
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Vermeulen, Roel
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Roulland, Sandri ...
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Casabonne, Delph ...
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Kaaks, Rudolf
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Fortner, Renee T ...
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Boeing, Heiner
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Trichopoulou, An ...
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La Vecchia, Carl ...
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Klinaki, Eleni
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Hansen, Louise
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Tjonneland, Anne
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Bonnet, Fabrice
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Fagherazzi, Guy
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Boutron-Ruault, ...
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Pala, Valeria
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Masala, Giovanna
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Sacerdote, Carlo ...
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Peeters, Petra H ...
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Bueno-de-Mesquit ...
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Weiderpass, Elis ...
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Dorronsoro, Mire ...
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Quiros, J. Ramon
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Barricarte, Aure ...
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Gavrila, Diana
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Agudo, Antonio
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Borgquist, Signe
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Rosendahl, Ann H ...
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Melin, Beatrice
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Wareham, Nick
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Khaw, Kay-Tee
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Gunter, Marc
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Riboli, Elio
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Vineis, Paolo
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Travis, Ruth C.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Karolinska Institutet
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Lund University