Search: (WFRF:(Gunter Marc J.)) pers:(Peeters Petra H) srt2:(2017) >
Endometrial cancer ...
Endometrial cancer risk prediction including serum-based biomarkers : results from the EPIC cohort
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- Fortner, Renee T. (author)
- German Cancer Research Centre
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- Huesing, Anika (author)
- German Cancer Research Centre
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- Kuehn, Tilman (author)
- German Cancer Research Centre
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- Konar, Meric (author)
- Hacettepe University,German Cancer Research Centre
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- Overvad, Kim (author)
- Aarhus University
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- Tjonneland, Anne (author)
- Danish Cancer Society
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- Hansen, Louise (author)
- Danish Cancer Society
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- Boutron-Ruault, Marie-Christine (author)
- Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay,Stabilite genetique et oncogenese
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- Severi, Gianluca (author)
- Human Genetics Foundation (HuGeF),Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay,Stabilite genetique et oncogenese
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- Fournier, Agnes (author)
- Stabilite genetique et oncogenese,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)
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- Boeing, Heiner (author)
- German Institute of Human Nutrition
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- Trichopoulou, Antonia (author)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Benetou, Vasiliki (author)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Orfanos, Philippos (author)
- Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
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- Masala, Giovanna (author)
- Cancer Research and Prevention Institute (ISPO)
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- Agnoli, Claudia (author)
- Istituto Nazionale dei Tumori
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- Mattiello, Amalia (author)
- University of Naples Federico II
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- Tumino, Rosario (author)
- Civic and M.P Arezzo Hospital
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- Sacerdote, Carlotta (author)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Bueno-de-Mesquita, H. B(as) (author)
- University of Malaya,Imperial College London,National Institute for Public Health and the Environment (RIVM)
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- Peeters, Petra H. M. (author)
- University Medical Center Utrecht,Imperial College London
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- Weiderpass, Elisabete (author)
- Karolinska Institutet,Karolinska Institute,Cancer Registry of Norway, Institute of Population-Based Cancer Research,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø
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- Gram, Inger T. (author)
- UiT The Arctic University of Norway, Tromsø
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- Gavrilyuk, Oxana (author)
- UiT The Arctic University of Norway, Tromsø,University Hospital of North Norway
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- Ramon Quiros, J. (author)
- Public Health Directorate
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- Maria Huerta, Jose (author)
- CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
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- Ardanaz, Eva (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Larranaga, Nerea (author)
- CIBER Epidemiology and Public Health (CIBERESP),Public Health Division of Gipuzkoa
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- Lujan-Barroso, Leila (author)
- Bellvitge Biomedical Research Institute
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- Sanchez-Cantalejo, Emilio (author)
- CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)
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- Butt, Salma Tunå (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Borgquist, Signe (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröstcancer-genetik,Institutionen för kliniska vetenskaper, Lund,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Breastcancer-genetics,Department of Clinical Sciences, Lund
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- Idahl, Annika (author)
- Umeå University,Umeå universitet,Obstetrik och gynekologi,Näringsforskning
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- Lundin, Eva (author)
- Umeå University,Umeå universitet,Patologi
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- Khaw, Kay-Tee (author)
- University of Cambridge
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- Allen, Naomi E. (author)
- University of Oxford
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- Rinaldi, Sabina (author)
- International Agency for Research on Cancer, World Health Organization
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- Dossus, Laure (author)
- International Agency for Research on Cancer, World Health Organization
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- Gunter, Marc (author)
- International Agency for Research on Cancer, World Health Organization
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- Merritt, Melissa A. (author)
- Imperial College London
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- Tzoulaki, Ioanna (author)
- Imperial College London
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- Riboli, Elio (author)
- Imperial College London
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- Kaaks, Rudolf (author)
- German Cancer Research Centre
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(creator_code:org_t)
- 2017-01-27
- 2017
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 140:6, s. 1317-1323
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
Close
- Endometrial cancer risk prediction models including lifestyle, anthropometric and reproductive factors have limited discrimina-tion. Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigat-ed for endometrial cancer. Using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we investigated the improvement in discrimination gained by adding serum biomarker concentrations to risk estimates derived from an existing risk prediction model based on epidemiologic factors. Serum concentrations of sex steroid hormones, metabolic markers, growth factors, adipokines and cytokines were evaluated in a step-wise backward selec-tion process; biomarkers were retained at p < 0.157 indicating improvement in the Akaike information criterion (AIC). Improvement in discrimination was assessed using the C-statistic for all biomarkers alone, and change in C-statistic from addition of biomarkers to preexisting absolute risk estimates. We used internal validation with bootstrapping (1000-fold) to adjust for over-fitting. Adiponectin, estrone, interleukin-1 receptor antagonist, tumor necrosis factor-alpha and triglycerides were select-ed into the model. After accounting for over-fitting, discrimination was improved by 2.0 percentage points when all evaluated biomarkers were included and 1.7 percentage points in the model including the selected biomarkers. Models including eti-ologic markers on independent pathways and genetic markers may further improve discrimination.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- endometrial cancer
- risk prediction
- prospective cohort
- sex steroids
- cytokines
- adipokines
- flammatory markers
- lipids
- growth factors
- metabolic markers
- adipokines
- cytokines
- endometrial cancer
- growth factors
- inflammatory markers
- lipids
- metabolic markers
- prospective cohort
- risk prediction
- sex steroids
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Fortner, Renee T ...
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Huesing, Anika
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Kuehn, Tilman
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Konar, Meric
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Overvad, Kim
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Tjonneland, Anne
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show more...
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Hansen, Louise
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Boutron-Ruault, ...
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Severi, Gianluca
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Fournier, Agnes
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Boeing, Heiner
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Trichopoulou, An ...
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Benetou, Vasilik ...
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Orfanos, Philipp ...
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Masala, Giovanna
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Agnoli, Claudia
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Mattiello, Amali ...
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Tumino, Rosario
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Sacerdote, Carlo ...
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Bueno-de-Mesquit ...
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Peeters, Petra H ...
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Weiderpass, Elis ...
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Gram, Inger T.
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Gavrilyuk, Oxana
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Ramon Quiros, J.
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Maria Huerta, Jo ...
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Ardanaz, Eva
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Larranaga, Nerea
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Lujan-Barroso, L ...
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Sanchez-Cantalej ...
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Butt, Salma Tunå
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Borgquist, Signe
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Idahl, Annika
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Lundin, Eva
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Khaw, Kay-Tee
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Allen, Naomi E.
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Rinaldi, Sabina
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Dossus, Laure
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Gunter, Marc
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Merritt, Melissa ...
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Tzoulaki, Ioanna
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Riboli, Elio
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Kaaks, Rudolf
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet