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MicroRNA expression...
MicroRNA expression in KRAS- and BRAF-mutated colorectal cancers
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- Lundberg, Ida (author)
- Umeå universitet,Patologi
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- Wikberg, Maria L. (author)
- Umeå universitet,Patologi
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- Ljuslinder, Ingrid (author)
- Umeå universitet,Onkologi
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- Li, Xingru (author)
- Umeå universitet,Patologi
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- Myte, Robin (author)
- Umeå universitet,Onkologi
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- Zingmark, Carl (author)
- Umeå universitet,Patologi
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- Löfgren-Burström, Anna (author)
- Umeå universitet,Patologi
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- Edin, Sofia (author)
- Umeå universitet,Patologi
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- Palmqvist, Richard (author)
- Umeå universitet,Patologi
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(creator_code:org_t)
- International Institute of Anticancer Research, 2018
- 2018
- English.
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In: Anticancer Research. - : International Institute of Anticancer Research. - 0250-7005 .- 1791-7530. ; 38:2, s. 677-683
- Related links:
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Background/Aim: KRAS and BRAF are two genes commonly mutated in colorectal cancer (CRC). Even though BRAF is a downstream target of KRAS in the MAPK signalling pathway, KRAS- and BRAF-mutated CRCs are found to display several different clinical and histopathological features. We investigated whether a differential expression of microRNAs (miRNAs) could explain the clinicopathological differences seen between KRAS-and BRAF-mutated CRCs.Materials and Methods: Using a PCR array, we analyzed the expression of 84 different miRNAs in CRC cell lines wild-type in KRAS and BRAF, or mutated in KRAS or BRAF.Results: Ten miRNAs were selected for further analyses in tumor tissue specimens (let-7a, let-7i, miR-10a, miR-10b, miR-31, miR-100, miR-181a, miR-181b, miR-372, and miR-373). BRAF-mutated tumors were found to express significantly higher levels of miR-31 as well as significantly lower levels of miR-373, compared to wild-type tumors.Conclusion: Our results suggest that KRAS and BRAF-mutated CRCs may have different miRNA signatures compared to CRC tumors wild-type in KRAS and BRAF. However, no difference in expression levels between KRAS-and BRAF-mutated tumors was evident for the miRNAs analyzed in this study.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- colorectal cancer
- miRNA
- KRAS
- BRAF
- molecular subgroups
Publication and Content Type
- ref (subject category)
- art (subject category)
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