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Preterm arteries in...
Preterm arteries in childhood : dimensions, intima-media thickness, and elasticity of the aorta, coronaries, and carotids in 6-y-old children born extremely preterm
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- Mohlkert, Lilly -Ann (författare)
- Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital
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- Hallberg, Jenny (författare)
- Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital
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- Broberg, Olof (författare)
- Lund University,Lunds universitet,Barnkardiologi,Forskargrupper vid Lunds universitet,Children cardiology,Lund University Research Groups,Skåne University Hospital
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- Hellström, Monica (författare)
- Umeå University,Umeå universitet,Pediatrik
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- Halvorsen, Cecilia Pegelow (författare)
- Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital
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- Sjoberg, Gunnar (författare)
- Karolinska Institutet,Karolinska Institute
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- Bonamy, Anna -Karin Edstedt (författare)
- Karolinska Institutet,Karolinska Institute
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- Liuba, Petru (författare)
- Lund University,Lunds universitet,Barnkardiologi,Forskargrupper vid Lunds universitet,Children cardiology,Lund University Research Groups,Skåne University Hospital
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- Fellman, Vineta (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Helsinki,Skåne University Hospital
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- Domellöf, Magnus (författare)
- Umeå University,Umeå universitet,Pediatrik
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- Norman, Mikael (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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(creator_code:org_t)
- 2016-10-27
- 2017
- Engelska.
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Ingår i: Pediatric Research. - : NATURE PUBLISHING GROUP. - 0031-3998 .- 1530-0447. ; 81:2, s. 299-306
- Relaterad länk:
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Preterm birth increases risk for adult cardiovascular disease. We hypothesized that arteries in 6-y-old children born preterm are narrower, with thicker intima-media and stiffer than in peers born at term. METHODS: Children born extremely preterm (EXP, n = 176, birthweights: 348-1,161 g) and at term (CTRL, n = 174, birth weights: 2,430-4,315 g) were included. Using ultrasonography, we determined diameters of the coronaries (CA), common carotid arteries (CCA) and aorta, the carotid intima media thickness (CIMT), and the stiffness index of the CCA and aorta. RESULTS: Arteries were 5-10% narrower in EXP than in CTRL (P < 0.005) but after adjustment for body surface area, diameter differences diminished or disappeared. EXP-children born small for gestational age exhibited similar arterial dimensions as those born appropriate for date. The cIMT was 0.38 (SD = 0.04) mm and did not differ between groups. Carotid but not aortic stiffness was lower in EXP than in CTRL. CONCLUSION: In 6-y-old children born extremely preterm, conduit arteries are of similar or smaller size than in controls born at term, and they have no signs of accelerated intima media thickening or arterial stiffening. While these findings are reassuring for these children and their families, the causal pathways from preterm birth to adult cardiovascular disease remain unknown.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Mohlkert, Lilly ...
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Hallberg, Jenny
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Broberg, Olof
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Hellström, Monic ...
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Halvorsen, Cecil ...
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Sjoberg, Gunnar
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visa fler...
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Bonamy, Anna -Ka ...
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Liuba, Petru
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Fellman, Vineta
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Domellöf, Magnus
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Norman, Mikael
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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Pediatric Resear ...
- Av lärosätet
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Umeå universitet
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Lunds universitet
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Karolinska Institutet