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Sökning: WFRF:(Vitonis Allison F.) > Correlates of circu...

  • Fortner, Renee T.German Cancer Research Centre (författare)

Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models : results from the EPIC cohort

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017-03-20
  • Springer Science and Business Media LLC,2017
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-133752
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133752URI
  • https://doi.org/10.1186/s13048-017-0315-6DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135500058URI
  • https://lup.lub.lu.se/record/14139206-cc32-4c82-a679-36e8ada53b80URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening.Methods: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of prediction models adjusting for correlates of the markers were evaluated among postmenopausal women in the nested case-control study (n = 590 cases). Generalized linear models were used to calculate geometric means of CA125, CA15.3, and HE4. CA72.4 above vs. below limit of detection was evaluated using logistic regression. Early detection prediction was modeled using conditional logistic regression.Results: CA125 concentrations were lower, and CA15.3 higher, in post- vs. premenopausal women (p ≤ 0.02). Among postmenopausal women, CA125 was higher among women with higher parity and older age at menopause (ptrend ≤ 0.02), but lower among women reporting oophorectomy, hysterectomy, ever use of estrogen-only hormone therapy, or current smoking (p < 0.01). CA15.3 concentrations were higher among heavier women and in former smokers (p ≤ 0.03). HE4 was higher with older age at blood collection and in current smokers, and inversely associated with OC use duration, parity, and older age at menopause (≤ 0.02). No associations were observed with CA72.4. Adjusting for correlates of the markers in prediction models did not improve the discrimination.Conclusions: This study provides insights into sources of variation in ovarian cancer early detection markers in healthy women and informs about the utility of individualizing marker cutpoints based on epidemiologic factors.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Vitonis, Allison F.Brigham and Women's Hospital / Harvard Medical School (författare)
  • Schock, HelenaGerman Cancer Research Centre (författare)
  • Huesing, AnikaGerman Cancer Research Centre (författare)
  • Johnson, TheronGerman Cancer Research Centre (författare)
  • Fichorova, Raina N.Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School (författare)
  • Fashemi, TitilayoBrigham and Women's Hospital / Harvard Medical School (författare)
  • Yamamoto, Hidemi S.Brigham and Women's Hospital / Harvard Medical School,Istituto Nazionale dei Tumori (författare)
  • Tjonneland, AnneDanish Cancer Society (författare)
  • Hansen, LouiseDanish Cancer Society (författare)
  • Overvad, KimAarhus University (författare)
  • Boutron-Ruault, Marie-ChristineCentre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay (författare)
  • Kvaskoff, MarinaCentre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay (författare)
  • Severi, GianlucaUniversity of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP),Human Genetics Foundation (HuGeF) (författare)
  • Boeing, HeinerGerman Institute of Human Nutrition (författare)
  • Trichopoulou, AntoniaHellenic Health Foundation, Athens,National and Kapodistrian University of Athens (författare)
  • Benetou, VassilikiNational and Kapodistrian University of Athens,Hellenic Health Foundation, Athens (författare)
  • La Vecchia, CarloHellenic Health Foundation, Athens,University of Milan (författare)
  • Palli, DomenicoCancer Research and Prevention Institute (ISPO) (författare)
  • Sieri, Sabina (författare)
  • Tumino, RosarioCivic and M.P Arezzo Hospital (författare)
  • Matullo, GiuseppeCitta' della Salute e della Scienza Hospital-University of Turin (författare)
  • Mattiello, AmaliaUniversity of Naples Federico II (författare)
  • Onland-Moret, N. CharlotteUniversity Medical Center Utrecht,Utrecht University (författare)
  • Peeters, Petra H.Imperial College London,University Medical Center Utrecht (författare)
  • Weiderpass, ElisabeteKarolinska Institutet,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research (författare)
  • Gram, Inger TorhildUiT The Arctic University of Norway, Tromsø (författare)
  • Jareid, MieUiT The Arctic University of Norway, Tromsø (författare)
  • Ramon Quiros, J.Public Health Directorate (författare)
  • Duell, Eric J.Catalan Institute of Oncology (författare)
  • Sanchez, Maria-JoseAndalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Dolores Chirlaque, MariaMurcia Regional Health Authority,University of Murcia (författare)
  • Ardanaz, EvaHealth Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)(Swepub:lu)extLU-05 (författare)
  • Larranaga, NereaCIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Nodin, BjörnLund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)immu-bnn (författare)
  • Brändstedt, JennyLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-jyb (författare)
  • Idahl, AnnikaUmeå University,Umeå universitet,Obstetrik och gynekologi(Swepub:umu)anid0002 (författare)
  • Khaw, Kay-TeeUniversity of Cambridge (författare)
  • Allen, NaomiUniversity of Oxford (författare)
  • Gunter, MarcInternational Agency for Research on Cancer, World Health Organization (författare)
  • Johansson, MattiasInternational Agency for Research on Cancer, World Health Organization (författare)
  • Dossus, LaureInternational Agency for Research on Cancer, World Health Organization (författare)
  • Merritt, Melissa A.Imperial College London (författare)
  • Riboli, ElioImperial College London (författare)
  • Cramer, Daniel W.Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School (författare)
  • Kaaks, RudolfGerman Cancer Research Centre (författare)
  • Terry, Kathryn L.Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School (författare)
  • German Cancer Research CentreBrigham and Women's Hospital / Harvard Medical School (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Ovarian Research: Springer Science and Business Media LLC101757-2215

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