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Correlates of circu...
Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models : results from the EPIC cohort
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- Fortner, Renee T. (författare)
- German Cancer Research Centre
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- Vitonis, Allison F. (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Schock, Helena (författare)
- German Cancer Research Centre
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- Huesing, Anika (författare)
- German Cancer Research Centre
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- Johnson, Theron (författare)
- German Cancer Research Centre
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- Fichorova, Raina N. (författare)
- Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School
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- Fashemi, Titilayo (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Yamamoto, Hidemi S. (författare)
- Brigham and Women's Hospital / Harvard Medical School,Istituto Nazionale dei Tumori
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- Tjonneland, Anne (författare)
- Danish Cancer Society
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- Hansen, Louise (författare)
- Danish Cancer Society
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- Overvad, Kim (författare)
- Aarhus University
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- Boutron-Ruault, Marie-Christine (författare)
- Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay
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- Kvaskoff, Marina (författare)
- Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay
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- Severi, Gianluca (författare)
- University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP),Human Genetics Foundation (HuGeF)
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Trichopoulou, Antonia (författare)
- Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
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- Benetou, Vassiliki (författare)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- La Vecchia, Carlo (författare)
- Hellenic Health Foundation, Athens,University of Milan
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- Palli, Domenico (författare)
- Cancer Research and Prevention Institute (ISPO)
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Sieri, Sabina (författare)
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- Matullo, Giuseppe (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Mattiello, Amalia (författare)
- University of Naples Federico II
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- Onland-Moret, N. Charlotte (författare)
- University Medical Center Utrecht,Utrecht University
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- Peeters, Petra H. (författare)
- Imperial College London,University Medical Center Utrecht
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- Weiderpass, Elisabete (författare)
- Karolinska Institutet,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research
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- Gram, Inger Torhild (författare)
- UiT The Arctic University of Norway, Tromsø
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- Jareid, Mie (författare)
- UiT The Arctic University of Norway, Tromsø
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- Ramon Quiros, J. (författare)
- Public Health Directorate
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- Duell, Eric J. (författare)
- Catalan Institute of Oncology
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- Sanchez, Maria-Jose (författare)
- Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
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- Dolores Chirlaque, Maria (författare)
- Murcia Regional Health Authority,University of Murcia
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- Ardanaz, Eva (författare)
- Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
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- Larranaga, Nerea (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Nodin, Björn (författare)
- Lund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Brändstedt, Jenny (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital
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- Idahl, Annika (författare)
- Umeå University,Umeå universitet,Obstetrik och gynekologi
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- Khaw, Kay-Tee (författare)
- University of Cambridge
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- Allen, Naomi (författare)
- University of Oxford
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- Gunter, Marc (författare)
- International Agency for Research on Cancer, World Health Organization
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- Johansson, Mattias (författare)
- International Agency for Research on Cancer, World Health Organization
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- Dossus, Laure (författare)
- International Agency for Research on Cancer, World Health Organization
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- Merritt, Melissa A. (författare)
- Imperial College London
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- Riboli, Elio (författare)
- Imperial College London
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- Cramer, Daniel W. (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Terry, Kathryn L. (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School
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(creator_code:org_t)
- 2017-03-20
- 2017
- Engelska.
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Ingår i: Journal of Ovarian Research. - : Springer Science and Business Media LLC. - 1757-2215. ; 10
- Relaterad länk:
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https://doi.org/10.1...
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visa fler...
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https://umu.diva-por... (primary) (Raw object)
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https://ovarianresea...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening.Methods: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of prediction models adjusting for correlates of the markers were evaluated among postmenopausal women in the nested case-control study (n = 590 cases). Generalized linear models were used to calculate geometric means of CA125, CA15.3, and HE4. CA72.4 above vs. below limit of detection was evaluated using logistic regression. Early detection prediction was modeled using conditional logistic regression.Results: CA125 concentrations were lower, and CA15.3 higher, in post- vs. premenopausal women (p ≤ 0.02). Among postmenopausal women, CA125 was higher among women with higher parity and older age at menopause (ptrend ≤ 0.02), but lower among women reporting oophorectomy, hysterectomy, ever use of estrogen-only hormone therapy, or current smoking (p < 0.01). CA15.3 concentrations were higher among heavier women and in former smokers (p ≤ 0.03). HE4 was higher with older age at blood collection and in current smokers, and inversely associated with OC use duration, parity, and older age at menopause (≤ 0.02). No associations were observed with CA72.4. Adjusting for correlates of the markers in prediction models did not improve the discrimination.Conclusions: This study provides insights into sources of variation in ovarian cancer early detection markers in healthy women and informs about the utility of individualizing marker cutpoints based on epidemiologic factors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Ovarian cancer
- Early detection markers
- CA125
- CA15.3
- HE4
- CA125
- CA15.3
- Early detection markers
- HE4
- Ovarian cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Fortner, Renee T ...
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Vitonis, Allison ...
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Schock, Helena
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Huesing, Anika
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Johnson, Theron
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Fichorova, Raina ...
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visa fler...
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Fashemi, Titilay ...
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Yamamoto, Hidemi ...
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Tjonneland, Anne
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Hansen, Louise
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Overvad, Kim
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Boutron-Ruault, ...
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Kvaskoff, Marina
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Severi, Gianluca
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Boeing, Heiner
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Trichopoulou, An ...
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Benetou, Vassili ...
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La Vecchia, Carl ...
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Palli, Domenico
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Sieri, Sabina
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Tumino, Rosario
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Matullo, Giusepp ...
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Mattiello, Amali ...
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Onland-Moret, N. ...
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Peeters, Petra H ...
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Weiderpass, Elis ...
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Gram, Inger Torh ...
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Jareid, Mie
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Ramon Quiros, J.
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Duell, Eric J.
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Sanchez, Maria-J ...
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Dolores Chirlaqu ...
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Ardanaz, Eva
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Larranaga, Nerea
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Nodin, Björn
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Brändstedt, Jenn ...
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Idahl, Annika
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Khaw, Kay-Tee
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Allen, Naomi
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Gunter, Marc
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Johansson, Matti ...
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Dossus, Laure
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Merritt, Melissa ...
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Riboli, Elio
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Cramer, Daniel W ...
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Kaaks, Rudolf
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Terry, Kathryn L ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reproduktionsmed ...
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Journal of Ovari ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet
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Lunds universitet