Spatial and quantitative datasets of the pancreatic beta-cell mass distribution in lean and obese mice

Parween, SabaUmeå universitet,Umeå centrum för molekylär medicin (UCMM) (författare)

A detailed understanding of pancreatic β-cell mass distribution is a key element to fully appreciate the pathophysiology of models of diabetes and metabolic stress. Commonly, such assessments have been performed by stereological approaches that rely on the extrapolation of two-dimensional data and provide very limited topological information. We present ex vivo optical tomographic data sets of the full β-cell mass distribution in cohorts of obese ob/ob mice and their lean controls, together with information about individual islet β-cell volumes, their three-dimensional coordinates and shape throughout the volume of the pancreas between 4 and 52 weeks of age. These data sets offer the currently most comprehensive public record of the β-cell mass distribution in the mouse. As such, they may serve as a quantitative and topological reference for the planning of a variety of in vivo or ex vivo experiments including computational modelling and statistical analyses. By shedding light on intra- and inter-lobular variations in β-cell mass distribution, they further provide a powerful tool for the planning of stereological sampling assessments.

Eriksson, MariaUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)maer0057 (författare)
Nord, ChristofferUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)chsv0004 (författare)
Kostromina, ElenaUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)elko0010 (författare)
Ahlgren, UlfUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)ulah0001 (författare)
Umeå universitetUmeå centrum för molekylär medicin (UCMM) (creator_code:org_t)

Av författaren/redakt...: Parween, Saba; Eriksson, Maria; Nord, Christoffe ...; Kostromina, Elen ...; Ahlgren, Ulf

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinsk biotek ...; och Biomedicinsk lab ...

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