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Thermogenic adipocy...
Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport
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Bartelt, Alexander (author)
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John, Clara (author)
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Schaltenberg, Nicola (author)
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Berbee, Jimmy F. P. (author)
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Worthmann, Anna (author)
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Cherradi, M. Lisa (author)
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Schlein, Christian (author)
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Piepenburg, Julia (author)
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Boon, Mariette R. (author)
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Rinninger, Franz (author)
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Heine, Markus (author)
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Toedter, Klaus (author)
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Niemeier, Andreas (author)
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- Nilsson, Stefan K. (author)
- Umeå universitet,Fysiologisk kemi,Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany
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Fischer, Markus (author)
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Wijers, Sander L. (author)
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Lichtenbelt, Wouter van Marken (author)
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Scheja, Ludger (author)
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Rensen, Patrick C. N. (author)
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Heeren, Joerg (author)
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(creator_code:org_t)
- 2017-04-19
- 2017
- English.
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In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 8
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https://umu.diva-por... (primary) (Raw object)
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Abstract
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- Brown and beige adipocytes combust nutrients for thermogenesis and through their metabolic activity decrease pro-atherogenic remnant lipoproteins in hyperlipidemic mice. However, whether the activation of thermogenic adipocytes affects the metabolism and anti-atherogenic properties of high-density lipoproteins (HDL) is unknown. Here, we report a reduction in atherosclerosis in response to pharmacological stimulation of thermogenesis linked to increased HDL levels in APOE(star)3-Leiden. CETP mice. Both cold-induced and pharmacological thermogenic activation enhances HDL remodelling, which is associated with specific lipidomic changes in mouse and human HDL. Furthermore, thermogenic stimulation promotes HDL-cholesterol clearance and increases macrophage-to-faeces reverse cholesterol transport in mice. Mechanistically, we show that intravascular lipolysis by adipocyte lipoprotein lipase and hepatic uptake of HDL by scavenger receptor B-I are the driving forces of HDL-cholesterol disposal in liver. Our findings corroborate the notion that high metabolic activity of thermogenic adipocytes confers atheroprotective properties via increased systemic cholesterol flux through the HDL compartment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bartelt, Alexand ...
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John, Clara
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Schaltenberg, Ni ...
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Berbee, Jimmy F. ...
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Worthmann, Anna
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Cherradi, M. Lis ...
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show more...
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Schlein, Christi ...
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Piepenburg, Juli ...
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Boon, Mariette R ...
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Rinninger, Franz
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Heine, Markus
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Toedter, Klaus
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Niemeier, Andrea ...
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Nilsson, Stefan ...
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Fischer, Markus
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Wijers, Sander L ...
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Lichtenbelt, Wou ...
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Scheja, Ludger
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Rensen, Patrick ...
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Heeren, Joerg
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medicinal Chemis ...
- Articles in the publication
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Nature Communica ...
- By the university
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Umeå University