Reduced hippocampal volume in non-demented carriers fo the apolipoprotein E ε4: Relation to chronological age and recognition memory

Reduced hippocampal volume in non-demented carriers fo the apolipoprotein E ε4 : Relation to chronological age and recognition memory

Apolipoprotein E ε4 (APOE ε4) is the main known genetic risk factor for Alzheimer's disease (AD). Some previous studies have reported structural brain changes as well as cognitive deficits in non-demented APOE ε4 carriers, but the pattern of results is inconsistent and studies with larger sample sizes have been called for. Here we compared hippocampal volume and recognition–memory performance between AD-symptom-free carriers (N = 30) and non-carriers (N = 30) of the APOE ε4 (age range: 49–79 years). We observed reduced right hippocampal volume in APOE ε4 carriers, and found that the difference was most pronounced before the age of 65. Further, the APOE ε4 carriers made significantly more false alarms in the recognition–memory test, and the number of false alarms correlated significantly with right hippocampus volume. These results indicate that relatively young individuals at genetic risk for AD have smaller hippocampal volume and lower performance on hippocampal-dependent cognitive tasks. A question for the future is whether smaller hippocampal volume represents early-onset hippocampal volume reduction or an inherent trait.

Larsson, AnneUmeå universitet,Radiofysik(Swepub:umu)anelan97 (författare)
Persson, JonasUmeå universitet,Institutionen för psykologi,Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA(Swepub:su)joper (författare)
Ingvar, MartinKarolinska Institutet (författare)
Nilsson, Lars-GöranStockholms universitet,Psykologiska institutionen(Swepub:su)lgn (författare)
Bäckman, LarsKarolinska Institutet (författare)
Adolfsson, RolfUmeå universitet,Psykiatri(Swepub:umu)road0001 (författare)
Cruts, MarcDepartment of Molecular Genetics, Flanders Interuniversity, Institute of Biotechnology, University of Antwerp, B-2610 Antwerpen, Belgium (författare)
Sleegers, KristelDepartment of Molecular Genetics VIB8, University of Antwerp, Campus CDE, Universiteitsplein 1, B-2610 Antwerp, Belgium (författare)
Van Broeckhoven, ChristineDepartment of Molecular Genetics, Flanders Interuniversity, Institute of Biotechnology, University of Antwerp, B-2610 Antwerpen, Belgium (författare)
Nyberg, Lars,1966-Umeå universitet,Institutionen för psykologi(Swepub:umu)lany0001 (författare)
Karolinska InstitutetRadiofysik (creator_code:org_t)

Av författaren/redakt...: Lind, Johanna; Larsson, Anne; Persson, Jonas; Ingvar, Martin; Nilsson, Lars-Gö ...; Bäckman, Lars; visa fler...; Adolfsson, Rolf; Cruts, Marc; Sleegers, Kriste ...; Van Broeckhoven, ...; Nyberg, Lars, 19 ...; visa färre...

Om ämnet

Av lärosätet: Umeå universitet; Karolinska Institutet; Stockholms universitet

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