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Clinical markers of...
Clinical markers of asthma and IgE assessed in parents before conception predict asthma and hayfever in the offspring
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- Bertelsen, R. J. (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning,Tartu Univ Hosp, Lung Clin, Tartu, Estonia.
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- Rava, M. (författare)
- INSERM U1168, VIMA Aging & Chron Dis Epidemiol & Publ Hlth Appr, Villejuif, France.;Univ Versailles St Quentin En Yvelines, UMR S 1168, Montigny Le Bretonneux, France.;Spanish Natl Canc Res Ctr CNIO, Genet & Mol Epidemiol Grp, Madrid, Spain.
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- Carsin, A. E. (författare)
- Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain.;Univ Pompeu Fabra, Barcelona, Spain.;CIBERESP, Barcelona, Spain.
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- Accordini, S. (författare)
- Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy.
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- Benediktsdottir, B. (författare)
- Univ Iceland, Fac Med, Reykjavik, Iceland.,INSERM, UMR 1152, Pathophysiol & Epidemiol Resp Dis, Epidemiol Team, Paris, France.;Univ Paris Diderot Paris 7, UMR 1152, Paris, France.
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- Dratva, J. (författare)
- Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.,Imperial Coll, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London, England.
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- Franklin, Karl A. (författare)
- Umeå universitet,Kirurgi,Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden.
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- Heinrich, J. (författare)
- Helmholtz Zentrum Munchen, Inst Epidemiol 1, German Res Ctr Environm Hlth, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany.
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- Holm, M. (författare)
- Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden.
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- Janson, C. (författare)
- Uppsala universitet,Lungmedicin och allergologi
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- Johannessen, A. (författare)
- Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Haukeland Hosp, Clin Res Ctr, Bergen, Norway.
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Jarvis, D. L. (författare)
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- Jogi, R. (författare)
- Univ Huelva, Dept Nursing, Huelva, Spain.
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Leynaert, B. (författare)
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- Norback, D. (författare)
- Uppsala universitet,Arbets- och miljömedicin
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- Omenaas, E. R. (författare)
- Univ Bergen, Dept Clin Sci, POB 7804, N-5020 Bergen, Norway.;Haukeland Hosp, Clin Res Ctr, Bergen, Norway.
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- Raherison, C. (författare)
- Bordeaux Univ, INSERM U897, Bordeaux, France.
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Sanchez-Ramos, J. L. (författare)
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- Schlunssen, V. (författare)
- Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.;Natl Res Ctr Working Environm, Copenhagen, Denmark.
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- Sigsgaard, T. (författare)
- Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.
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- Dharmage, S. C. (författare)
- Univ Melbourne, Melbourne Sch Populat Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia.,Haukeland Hosp, Dept Occupat Med, Bergen, Norway.;Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway.
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Svanes, C. (författare)
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(creator_code:org_t)
- 2017-03-28
- 2017
- Engelska.
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Ingår i: Clinical and Experimental Allergy. - : Wiley. - 0954-7894 .- 1365-2222. ; 47:5, s. 627-638
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://onlinelibrar...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Mice models suggest epigenetic inheritance induced by parental allergic disease activity. However, we know little of how parental disease activity before conception influences offspring's asthma and allergy in humans.Objective: We aimed to assess the associations of parental asthma severity, bronchial hyperresponsiveness (BHR), and total and specific IgEs, measured before conception vs. after birth, with offspring asthma and hayfever.Methods: The study included 4293 participants (mean age 34, 47% men) from the European Community Respiratory Health Survey (ECRHS) with information on asthma symptom severity, BHR, total and specific IgEs from 1991 to 1993, and data on 9100 offspring born 1972–2012. Adjusted relative risk ratios (aRRR) for associations of parental clinical outcome with offspring allergic disease were estimated with multinomial logistic regressions.Results: Offspring asthma with hayfever was more strongly associated with parental BHR and specific IgE measured before conception than after birth [BHR: aRRR = 2.96 (95% CI: 1.92, 4.57) and 1.40 (1.03, 1.91), respectively; specific IgEs: 3.08 (2.13, 4.45) and 1.83 (1.45, 2.31), respectively]. This was confirmed in a sensitivity analysis of a subgroup of offspring aged 11–22 years with information on parental disease activity both before and after birth.Conclusion & Clinical Relevance: Parental BHR and specific IgE were associated with offspring asthma and hayfever, with the strongest associations observed with clinical assessment before conception as compared to after birth of the child. If the hypothesis is confirmed in other studies, parental disease activity assessed before conception may prove useful for identifying children at risk for developing asthma with hayfever.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- asthma
- clinical immunology
- European Community Respiratory Health Survey
- epidemiology
- IgE
- fspring
- preconception
- rhinitis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Bertelsen, R. J.
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Rava, M.
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Carsin, A. E.
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Accordini, S.
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Benediktsdottir, ...
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Dratva, J.
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visa fler...
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Franklin, Karl A ...
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Heinrich, J.
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Holm, M.
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Janson, C.
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Johannessen, A.
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Jarvis, D. L.
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Jogi, R.
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Leynaert, B.
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Norback, D.
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Omenaas, E. R.
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Raherison, C.
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Sanchez-Ramos, J ...
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Schlunssen, V.
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Sigsgaard, T.
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Dharmage, S. C.
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Svanes, C.
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Clinical and Exp ...
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Umeå universitet
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