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Activation of influenza virus-specific CD4+ and CD8+ T cells : a new role for plasmacytoid dendritic cells in adaptive immunity
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- Fonteneau, Jean-François (author)
- Laboratory of Molecular Neuro-Oncology, and the Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY; and the Department of Immunology, DNAX Research Institute, Palo Alto, CA, USA
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- Gilliet, Michel (author)
- Laboratory of Molecular Neuro-Oncology, and the Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY; and the Department of Immunology, DNAX Research Institute, Palo Alto, CA, USA
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- Larsson, Marie, 1966- (author)
- Laboratory of Molecular Neuro-Oncology, and the Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY; and the Department of Immunology, DNAX Research Institute, Palo Alto, CA, USA
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- The American Society of Hematology, 2003
- 2003
- English.
- In: Blood. - : The American Society of Hematology. - 0006-4971 .- 1528-0020. ; 101:9, s. 3520-3526
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Plasmacytoid dendritic cells (pDCs) contribute to innate antiviral immune responses by producing type I interferons (IFNs) upon exposure to enveloped viruses. However, their role in adaptive immune responses, such as the initiation of antiviral T-cell responses, is not known. In this study, we examined interactions between blood pDCs and influenza virus with special attention to the capacity of pDCs to activate influenza-specific T cells. pDCs were compared with CD11c+ DCs, the most potent antigen-presenting cells (APCs), for their capacity to activate T-cell responses. We found that like CD11c+ DCs, pDCs mature following exposure to influenza virus, express CCR7, and produce proinflammatory chemokines, but differ in that they produce type I IFN and are resistant to the cytopathic effect of the infection. After influenza virus exposure, both DC types exhibited an equivalent efficiency to expand anti–influenza virus cytotoxic T lymphocytes (CTLs) and T helper 1 (TH1) CD4+ T cells. Our results pinpoint a new role of pDCs in the induction of antiviral T-cell responses and suggest that these DCs play a prominent role in the adaptive immune response against viruses.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
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- NATURAL SCIENCES
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- Blood
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- Linköping University
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